INT74815

Context Info Confidence 0.36 First Reported 1998 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 12 Disease Relevance 3.62 Pain Relevance 4.25

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)

Anatomy Link Frequency neurons 3 neuropil 1 SCG 1 Grm5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate receptor 50 100.00 Antinociceptive 1 99.98 Pain 148 99.64 Analgesic 1 99.52 antagonist 72 98.24 Dorsal horn 8 94.72 Spinal cord 11 94.24 intrathecal 2 93.68 Arthritis 58 91.96 GABAergic 32 90.08

Disease Link Frequency Relevance Heat Pain 144 99.64 Ganglion Cysts 46 96.60 Nociception 28 95.72 Apoptosis 5 93.88 Cancer 5 93.24 Arthritis 98 91.96 INFLAMMATION 8 83.76 Neuropathic Pain 27 82.64 Hyperalgesia 5 79.36 Anxiety Disorder 9 65.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats.

mGluR5 Binding (activity) of associated with analgesic and antinociceptive

1) Confidence 0.36 Published 1998 Journal Neuroreport Section Title Doc Link 9559947 Disease Relevance 0.75 Pain Relevance 1.03

In addition to comparing predicted ligand binding energies, we also investigated the details of the interactions between the ligand binding pockets and the ligands for mGluR5.

mGluR5 Binding (interactions) of

2) Confidence 0.36 Published 2008 Journal BMC Bioinformatics Section Body Doc Link PMC2259417 Disease Relevance 0 Pain Relevance 0

mGluR1, but not mGluR5, can account for the pain-related changes of excitatory and inhibitory transmission in CeLC neurons

mGluR5 Binding (account) of in neurons associated with pain

3) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.70 Pain Relevance 0.78

The results obtained with highly selective antagonists for mGluR1 and mGluR5 [40,42,52,53] show that presynaptic mGluR1, but not postsynaptic mGluR5, can account for the pain-related changes of excitatory and inhibitory transmission in CeLC neurons.

mGluR5 Binding (account) of in neurons associated with pain and antagonist

4) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.62 Pain Relevance 0.79

It is known that NVmes neurons express mGluR5 receptors from birth [90], [91] and we have now shown that the annulospiral endings bind mGluR5 antibodies.

mGluR5 Binding (bind) of in neurons

5) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886111 Disease Relevance 0.82 Pain Relevance 1.03

Compelling anatomical and electrophysiological studies have indicated the presence of mGluR1 and mGluR5 in the neuropil of all the trigeminal nuclei [15].

mGluR5 Binding (presence) of in neuropil

6) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.32

In our experiments, the most important receptor in mediating astrocytic activation to sensory and CT inputs was mGluR5.

mGluR5 Binding (experiments) of

7) Confidence 0.12 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2909395 Disease Relevance 0 Pain Relevance 0.22

Finally, CaM binding to the mGluRs did not appear to be Ca2+-dependent.

mGluRs Binding (binding) of

8) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

To assess the role of Siah1a binding, specific group I mGluRs were heterologously expressed in sympathetic neurons from the rat superior cervical ganglion (SCG), which do not natively express mGluRs [37,38].

mGluRs Binding (binding) of in SCG associated with ganglion cysts

9) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.34 Pain Relevance 0

Recent work has shown that Siah can bind group I metabotropic glutamate receptors (mGluRs), but the functional consequences of this interaction are unknown.

mGluRs Binding (bind) of associated with glutamate receptor

10) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC58838 Disease Relevance 0.08 Pain Relevance 0.09

Further studies will be needed to determine if group I mGluRs and Siah1a interact physiologically, and whether this interaction has functional consequences.

mGluRs Binding (interact) of

11) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

This interaction was specific for group I mGluRs, as it was not observed in the analogous sequences from group II (mGluR2) or group III (mGluR7) receptors.

mGluRs Binding (interaction) of

12) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.30 Pain Relevance 0

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