INT74823

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.67
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LTA) extracellular space (LTA) extracellular region (LTA)
cell-cell signaling (LTA)
Anatomy Link Frequency
lymph node 2
LTA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 97.06 Very High Very High Very High
tolerance 3 95.68 Very High Very High Very High
Inflammation 6 94.88 High High
Inflammatory response 1 93.44 High High
Sciatic nerve 2 88.12 High High
Spinal cord 2 87.40 High High
Neuritis 2 75.00 Quite High
Angina 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 2 97.84 Very High Very High Very High
Cancer 2 97.66 Very High Very High Very High
INFLAMMATION 8 94.88 High High
Disease 19 84.64 Quite High
Generalized Anxiety Disorder 2 81.88 Quite High
Immunization 2 80.36 Quite High
Diabetes Mellitus 69 78.32 Quite High
Experimental Autoimmune Myasthenia Gravis 4 75.00 Quite High
Neuritis 1 75.00 Quite High
Encephalitis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The haplotypic structure is complex and there is also a complex interaction between genes and gene products, as illustrated by the TNF gene polymorphism that can influence transcription of LTA [8], and receptor for advanced glycation end-products (RAGE), which after binding to its ligand can increase production of pro-inflammatory cytokines, among them TNF-?
Positive_regulation (influence) of Transcription (transcription) of LTA associated with inflammation and cytokine
1) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 0.66 Pain Relevance 0.14
Numbers of AChR-, MBP-, BPM-reactive Th1 type of cytokine interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha mRNA expression in lymph node cells were markedly suppressed, while transforming growth factor-beta (TGF-beta) mRNA expression was upregulated from nasally tolerized rats, suggesting an active suppression mechanism may act partly in the induction of tolerance.
Positive_regulation (upregulated) of Transcription (expression) of factor-beta in lymph node associated with necrosis, cancer, tolerance and cytokine
2) Confidence 0.00 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 1.01 Pain Relevance 0.46

General Comments

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