INT74824

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.58
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
lymph node 2
livers 2
fibroblasts 2
extracellular matrix 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 12 99.78 Very High Very High Very High
Inflammation 19 98.42 Very High Very High Very High
fibrosis 10 98.00 Very High Very High Very High
cytokine 51 97.20 Very High Very High Very High
tolerance 5 95.68 Very High Very High Very High
Sciatic nerve 3 89.68 High High
Spinal cord 2 86.88 High High
Peripheral nervous system 1 70.72 Quite High
substance P 1 50.00 Quite Low
calcitonin gene related peptide 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 11 99.78 Very High Very High Very High
INFLAMMATION 19 98.42 Very High Very High Very High
Fibrosis 8 98.00 Very High Very High Very High
Necrosis 6 97.58 Very High Very High Very High
Cancer 9 97.40 Very High Very High Very High
Cv General 3 Under Development 1 86.36 High High
Disease 10 84.12 Quite High
Increased Venous Pressure Under Development 4 82.64 Quite High
Immunization 2 79.84 Quite High
Experimental Autoimmune Myasthenia Gravis 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TGFbeta mRNA expression was increased in epithelial cells exposed to fibroblasts but not to mast cells.
Neg (not) Positive_regulation (increased) of Transcription (expression) of TGFbeta in fibroblasts
1) Confidence 0.67 Published 2010 Journal Regul. Pept. Section Body Doc Link 20079377 Disease Relevance 0 Pain Relevance 0
Increased TGF-beta(1) transcription and translation were associated with enhanced synthesis of extracellular matrix components including the collagen types I and III as shown by immunocytochemistry and enhanced incorporation of [3H]proline.
Positive_regulation (Increased) of Transcription (transcription) of TGF-beta in extracellular matrix
2) Confidence 0.47 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.17 Pain Relevance 0
In a pro-inflammatory environment (obtained by an excess of IL-18), inhibition of TWEAK was able to increase significantly NKp46 and TGF-beta1 mRNA expressions.


Positive_regulation (increase) of Transcription (expressions) of TGF-beta1 associated with inflammation
3) Confidence 0.23 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.16 Pain Relevance 0.08
Increased mRNA expression for IFN-gamma and TNF-alpha was registered correlating with the peak of clinical signs of EAN, and high levels of mRNA expression for IL-4, IL-10, and TGF-beta were associated with EAN recovery.
Positive_regulation (levels) of Transcription (expression) of TGF-beta associated with neuritis
4) Confidence 0.08 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.10 Pain Relevance 1.15
Transforming growth factor beta transcription is also increased with CNI use which may affect the development of fibrosis in transplanted livers.
Positive_regulation (increased) of Transcription (transcription) of Transforming growth factor beta in livers associated with fibrosis
5) Confidence 0.05 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.16 Pain Relevance 0.14
Numbers of AChR-, MBP-, BPM-reactive Th1 type of cytokine interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha mRNA expression in lymph node cells were markedly suppressed, while transforming growth factor-beta (TGF-beta) mRNA expression was upregulated from nasally tolerized rats, suggesting an active suppression mechanism may act partly in the induction of tolerance.
Positive_regulation (upregulated) of Transcription (expression) of TGF-beta in lymph node associated with necrosis, cancer, tolerance and cytokine
6) Confidence 0.04 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 1.00 Pain Relevance 0.46

General Comments

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