INT74826

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 131
Total Number 135
Disease Relevance 61.83
Pain Relevance 100.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
spinal cord 23
spinal 18
astrocytes 10
neuronal 5
neurons 5
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 4194 100.00 Very High Very High Very High
Central nervous system 167 100.00 Very High Very High Very High
antagonist 156 100.00 Very High Very High Very High
narcan 45 99.90 Very High Very High Very High
Spinal cord 1781 99.88 Very High Very High Very High
Nucleus accumbens 88 99.86 Very High Very High Very High
Inflammation 1069 99.84 Very High Very High Very High
Neuropathic pain 963 99.84 Very High Very High Very High
Morphine 248 99.66 Very High Very High Very High
Glutamate receptor 371 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 64 99.88 Very High Very High Very High
Neuropathic Pain 1651 99.84 Very High Very High Very High
INFLAMMATION 1085 99.84 Very High Very High Very High
Targeted Disruption 8 99.84 Very High Very High Very High
Nociception 902 99.60 Very High Very High Very High
Stress 319 99.44 Very High Very High Very High
Disease 105 99.40 Very High Very High Very High
Hyperalgesia 765 99.32 Very High Very High Very High
Nervous System Injury 718 99.24 Very High Very High Very High
Urological Neuroanatomy 4 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of GLT-1 mRNA was significantly decreased in the striatum and thalamus of morphine-dependent rats, and significantly increased in the striatum 2 h after the naloxone-precipitated withdrawal, compared with that of naive rats.
Gene_expression (expression) of GLT-1 mRNA in thalamus associated with narcan, thalamus, withdrawal and morphine
1) Confidence 0.78 Published 2001 Journal Brain Res. Section Abstract Doc Link 11423104 Disease Relevance 0.17 Pain Relevance 0.96
The expression of mRNAs for the glial glutamate transporters, GLT-1 and GLAST, in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal was investigated by Northern blot analysis.
Gene_expression (expression) of GLT-1 in brain associated with addiction, glutamate, narcan, withdrawal and morphine
2) Confidence 0.78 Published 2001 Journal Brain Res. Section Abstract Doc Link 11423104 Disease Relevance 0.17 Pain Relevance 0.88
In the present study we assessed (i) the regulation of GLT-1 expression in the spinal cord after peripheral nociceptive stimulation and (ii) the nociceptive behavior of rats following inhibition or transient knockdown of spinal GLT-1.
Gene_expression (expression) of GLT-1 in spinal cord associated with nociception and spinal cord
3) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535941 Disease Relevance 0.49 Pain Relevance 0.29
Similar results were obtained with a transient reduction of GLT-1 protein expression by antisense oligonucleotides.
Gene_expression (expression) of GLT-1 protein
4) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535941 Disease Relevance 0.57 Pain Relevance 0.34
Formalin injection into one hindpaw caused a rapid transient upregulation of GLT-1 protein expression in the spinal cord which did not occur when rats were pretreated with morphine (10 mg/kg, i.p.) suggesting that the nociceptive input specifically caused the increase of GLT-1 transcription.
Gene_expression (expression) of GLT-1 protein in spinal cord associated with nociception, morphine and spinal cord
5) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535941 Disease Relevance 0.57 Pain Relevance 0.31
Local overexpression of GLT-1 within the bilateral LC by the recombinant adenoviruses before implantation of the morphine pellet significantly inhibited various somatic signs of naloxone-precipitated morphine withdrawal, compared with the control.
Gene_expression (overexpression) of GLT-1 associated with locus ceruleus, narcan, withdrawal and morphine
6) Confidence 0.77 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750980 Disease Relevance 0.41 Pain Relevance 1.55
Effect of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus by recombinant adenoviruses on morphine physical dependence in rats.
Gene_expression (transfer) of GLT-1 in locus coeruleus associated with glutamate, physical dependence, locus ceruleus and morphine
7) Confidence 0.77 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 14750980 Disease Relevance 0.42 Pain Relevance 1.40
In cultured astrocytes, the expression of GLT-1 mRNA was regulated by agents activating the cAMP pathway, as well as beta-adrenergic agonist and dopamine, but not morphine.
Gene_expression (expression) of GLT-1 mRNA in astrocytes associated with dopamine, agonist and morphine
8) Confidence 0.77 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.13 Pain Relevance 1.66
These results suggest that the changes of GLT-1 expression, which alter the glutamate uptake and affect the glutamatergic transmission efficiency, play a role in the development of morphine dependence and the expression of morphine withdrawal.
Gene_expression (expression) of GLT-1 associated with addiction, glutamate, withdrawal and morphine
9) Confidence 0.77 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.22 Pain Relevance 1.61
By northern blot analysis, the expression of GLT-1 mRNA was found to decrease significantly in the striatum and thalamus of morphine-dependent rats, and to increase significantly in the striatum 2 hr after the naloxone-precipitated withdrawal.
Gene_expression (expression) of GLT-1 mRNA in striatum associated with narcan, thalamus, withdrawal and morphine
10) Confidence 0.77 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.16 Pain Relevance 1.31
Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia.
Gene_expression (expression) of GLT-1 in spinal cord associated with hyperalgesia, glutamate, taxol and spinal cord
11) Confidence 0.76 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15975716 Disease Relevance 0.25 Pain Relevance 0.63
Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P<0.001) and 23% (P<0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats.
Gene_expression (expression) of GLT-1 in spinal associated with hyperalgesia, spinal dorsal horn and taxol
12) Confidence 0.76 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15975716 Disease Relevance 0.33 Pain Relevance 0.86
Similarly, we found a decrease in GLT-1 expression in the membrane fraction of the spinal cord at 7 days following pSNL, although the total amount of GLT-1 protein was not changed in the present pSNL-induced neuropathic pain model in contrast to previous reports using other neuropathic pain models [19,22].
Gene_expression (expression) of GLT-1 in spinal cord associated with eae, neuropathic pain and spinal cord
13) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.82 Pain Relevance 1.05
Our results suggest that the increase of glutamate uptake activity following overexpression of spinal GLT-1 protein decreases the excessive extracellular glutamate level; this in turn inhibits the generation of neuronal plasticity related to central sensitization following peripheral inflammation and nerve injury.
Gene_expression (overexpression) of GLT-1 protein in neuronal associated with glutamate, nervous system injury, inflammation and central sensitization
14) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.36 Pain Relevance 1.43
Using the recombinant adenoviruses, we showed that gene transfer of GLT-1 into the spinal cord had no effect on the acute nociceptive responses to mechanical and thermal stimuli in naive rats.
Gene_expression (transfer) of GLT-1 in spinal cord associated with nociception and spinal cord
15) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.65 Pain Relevance 0.46
Our present findings suggest that the expression of GLT-1 in the spinal cord plays little role in the maintenance of neuropathic pain, at least in the present conditions.
Gene_expression (expression) of GLT-1 in spinal cord associated with neuropathic pain and spinal cord
16) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.96 Pain Relevance 1.15
The present study showed that contralateral allodynia was also prevented by the unilateral gene transfer of GLT-1 into the ipsilateral spinal cord, although the unilateral gene transfer did not spread to the contralateral spinal cord.
Gene_expression (transfer) of GLT-1 in spinal cord associated with allodynia and spinal cord
17) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.17 Pain Relevance 1.41
Because GLT-1 is expressed mainly in astrocytes, the adenovirus-mediated expression system seemed likely to be suitable for the present study.
Gene_expression (expressed) of GLT-1 in astrocytes
18) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.43 Pain Relevance 0.23
We previously reported that an infusion of Ad-GLT-1 into specific brain areas efficiently increased GLT-1 expression at 2 and 5 days, and this expression remained stable up to 8 days after the infusion [29,30].
Gene_expression (expression) of GLT-1 in brain
19) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.39 Pain Relevance 0.29
Many previous studies have shown that the expression of GLT-1 and glutamate uptake activity are decreased 7–14 days after nerve injury [5,19,20,22].
Gene_expression (expression) of GLT-1 in nerve associated with glutamate and nervous system injury
20) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.68 Pain Relevance 1.03

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