INT74828

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 3.92
Pain Relevance 10.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
nucleus accumbens 2
neurons 1
nerve 1
striatum 1
frontal cortex 1
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 241 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Antinociceptive 5 99.78 Very High Very High Very High
Nucleus accumbens 22 99.70 Very High Very High Very High
Morphine 44 99.42 Very High Very High Very High
excitatory amino acid 9 99.32 Very High Very High Very High
Endep 7 99.04 Very High Very High Very High
opioid receptor 4 99.04 Very High Very High Very High
narcan 14 98.84 Very High Very High Very High
Analgesic 2 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 33 99.36 Very High Very High Very High
Urological Neuroanatomy 2 99.08 Very High Very High Very High
Nociception 38 98.92 Very High Very High Very High
Stress 115 98.32 Very High Very High Very High
Schizophrenia 6 97.60 Very High Very High Very High
Drug Dependence 5 96.88 Very High Very High Very High
Psychosis 7 95.88 Very High Very High Very High
Hypoxia 63 91.80 High High
Neuropathic Pain 78 90.20 High High
Neurological Disease 4 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo microdialysis experiments revealed that the extracellular glutamate levels was elevated in the striatum and nucleus accumbens, in which the changes of GLT-1 mRNA level were observed, during naloxone-precipitated morphine withdrawal.
Regulation (changes) of GLT-1 mRNA in nucleus accumbens associated with nucleus accumbens, glutamate, narcan, withdrawal and morphine
1) Confidence 0.61 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.14 Pain Relevance 1.65
The regulation of the glial glutamate transporter GLT-1 is potentially important in synaptic modulation.
Regulation (regulation) of GLT-1 associated with glutamate
2) Confidence 0.55 Published 1998 Journal FEBS Lett. Section Abstract Doc Link 9563512 Disease Relevance 0 Pain Relevance 0.62
In the present study, we examined the effects of gene transfer of a glial glutamate transporter, GLT-1, into the NAc shell by recombinant adenoviruses on methamphetamine- and morphine-induced conditioned place preference in rats.
Spec (examined) Regulation (effects) of GLT-1 in NAc associated with nucleus accumbens, glutamate and morphine
3) Confidence 0.43 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324108 Disease Relevance 0 Pain Relevance 0.88
Regulation of the glial glutamate transporter GLT-1 by glutamate and delta-opioid receptor stimulation.
Regulation (Regulation) of GLT-1 associated with glutamate, enkephalin and opioid receptor
4) Confidence 0.40 Published 1998 Journal FEBS Lett. Section Title Doc Link 9563512 Disease Relevance 0 Pain Relevance 0.75
Interestingly, chronic haloperidol treatment down regulate EAAT2 in the cingulate- and frontal cortex in rats [45], indicating that decreased EAAT2 levels rather may reflect a beneficial condition following the antipsychotic treatment of schizophrenia.
Regulation (regulate) of EAAT2 in frontal cortex associated with urological neuroanatomy and schizophrenia
5) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.74 Pain Relevance 0.60
We examined the effects of PBS, Ad-EGFP, and Ad-GLT-1 on the acute mechanical and thermal nociceptive responses of naive rats 7 days after their intraspinal infusion.
Spec (examined) Regulation (effects) of GLT-1 associated with nociception
6) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.42 Pain Relevance 0.17
In the animals infused with Ad-EGFP, total amount of GLT-1 protein was not changed, while the GLT-1 level in the membrane fraction decreased at 7 days following pSNL (14 days after intraspinal infusion).
Neg (not) Regulation (changed) of GLT-1 protein
7) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.43 Pain Relevance 0.54
In addition, maternal separation produces a reduction in glial excitatory amino acid transporter (EAAT)-1 with no change in EAAT-2 or gamma-amino butyric acid transporters.
Neg (no) Regulation (change) of EAAT-2
8) Confidence 0.23 Published 2010 Journal Gastroenterology Section Body Doc Link 20226190 Disease Relevance 0.11 Pain Relevance 0
In vivo microdialysis experiments revealed that the extracellular glutamate levels was elevated in the striatum and nucleus accumbens, in which the changes of GLT-1 mRNA level were observed, during naloxone-precipitated morphine withdrawal.
Regulation (changes) of GLT-1 mRNA in striatum associated with nucleus accumbens, glutamate, narcan, withdrawal and morphine
9) Confidence 0.21 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.14 Pain Relevance 1.65
Amitriptyline preserves morphine's antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats.
Regulation (regulating) of GLT-1 associated with glutamate, antinociceptive, endep, excitatory amino acid and morphine
10) Confidence 0.18 Published 2007 Journal Pain Section Title Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.89
Importantly, the cellular location of GLT-1 and GLAST was also altered in response to nerve injury.
Regulation (altered) of GLT-1 in nerve associated with nervous system injury
11) Confidence 0.11 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2676254 Disease Relevance 0.27 Pain Relevance 0.30
Activity of the GS could be involved in the regulation of concentration of glutamate in the extra-cellular space of neurons with other systems, astroglial glutamate transporter-I (GLT-1), and also microglial antiporter for cystine and glutamate which may release glutamate when the demand of glutathione synthesis was increased by oxidative stress 55.
Regulation (regulation) of GLT-1 in neurons associated with stress and glutamate
12) Confidence 0.06 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.66 Pain Relevance 0.29
Researchers have postulated that the up-regulation of GLT-1 levels in this region is a compensatory response to chronic elevations of extracellular glutamate levels.
Regulation (regulation) of GLT-1 associated with glutamate
13) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.75 Pain Relevance 0.53
It is noteworthy that the related group II mGlu receptors, which also couple through Gi/o have been shown to produce an up-regulation of the glial glutamate transporters GLT-1 and GLAST through a mitogen-activated protein (MAP) kinase and phosphatidyl-inositol-3 (PI-3) kinase-dependent pathway (Aronica et al., 2003).
Regulation (regulation) of GLT-1 associated with glutamate
14) Confidence 0.05 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989582 Disease Relevance 0.26 Pain Relevance 0.43

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