INT74838

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Context Info
Confidence 0.34
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 6.93
Pain Relevance 12.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sorbs1) transport (Sorbs1) plasma membrane (Sorbs1)
cytoskeleton (Sorbs1) nucleus (Sorbs1) cytoplasm (Sorbs1)
Anatomy Link Frequency
sciatic nerve 1
spinal cords 1
nerve 1
B cells 1
proximal 1
Sorbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 334 100.00 Very High Very High Very High
qutenza 327 100.00 Very High Very High Very High
c fibre 60 100.00 Very High Very High Very High
Action potential 56 100.00 Very High Very High Very High
Nerve growth factor 606 99.96 Very High Very High Very High
Calcitonin gene-related peptide 578 99.68 Very High Very High Very High
dorsal root ganglion 288 98.20 Very High Very High Very High
Eae 117 95.00 High High
Spinal cord 45 93.56 High High
hyperexcitability 42 93.56 High High
Disease Link Frequency Relevance Heat
Nerve Compression Syndromes 186 99.44 Very High Very High Very High
Hypersensitivity 42 99.16 Very High Very High Very High
Injury 379 98.52 Very High Very High Very High
Ganglion Cysts 654 98.20 Very High Very High Very High
Congenital Anomalies 12 97.32 Very High Very High Very High
Hyperalgesia 42 93.48 High High
Pain 39 90.80 High High
Nociception 76 90.24 High High
Cancer 1 90.16 High High
Nervous System Injury 66 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAP stimulation induced a significant CGRP release, which, however, did not correlate with the temporal development of OA in STR/1N mice.
Positive_regulation (stimulation) of CAP
1) Confidence 0.34 Published 2004 Journal J. Rheumatol. Section Body Doc Link 15468368 Disease Relevance 0.06 Pain Relevance 0
In addition, the number of antibody-producing B cells and serum IgG and IgM levels increased in mice fed 20 ppm CAP as compared to the control with no CAP.
Positive_regulation (increased) of CAP in B cells associated with qutenza
2) Confidence 0.26 Published 1998 Journal Int J Vitam Nutr Res Section Abstract Doc Link 9565827 Disease Relevance 0.18 Pain Relevance 1.06
mM) on the CAP that was incubated at 30?
Positive_regulation (incubated) of CAP associated with action potential
3) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2952823 Disease Relevance 0.16 Pain Relevance 0.70
First, latencies of the second and third CAP components are markedly increased with respect to controls, indicating slower nerve conduction in medium and small fibers.
Positive_regulation (increased) of CAP in nerve
4) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0.17 Pain Relevance 0.10
Similar to optic nerves, 4-AP increases the CAP amplitude in small diameter axons from wild-type and Claudin 11┬ľnull spinal cords.
Positive_regulation (increases) of CAP in spinal cords
5) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0.11
Thus, the amplitude and shape of ventral column CAPs from Claudin 11┬ľnull mice are similar to controls and differ only by an increase in CAP duration (Fig.
Positive_regulation (increase) of CAP in ventral
6) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0.11
Because treatment with either GDNF or NGF induced a large increase in 100 nM CAP-evoked CGRP release, we assessed the effect of supplementation with these growth factors on the receptor pharmacodynamics of this response compared with no growth factor supplementation.
Positive_regulation (increase) of CAP associated with qutenza, nerve growth factor and calcitonin gene-related peptide
7) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.13
Treatment of cultures with NGF or GDNF resulted in a concentration-dependent enhancement of this effect, with significant increases in CAP-evoked CGRP release at 1, 10 and 100 ng/ml.
Positive_regulation (increases) of CAP associated with qutenza, nerve growth factor and calcitonin gene-related peptide
8) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.41
In every case, GDNF and NGF (except 1 ng/ml NGF) supplementation significantly enhanced CAP-evoked CGRP release over the same concentration of BDNF (Fig 8A).
Neg (except) Positive_regulation (supplementation) of CAP associated with qutenza, nerve growth factor and calcitonin gene-related peptide
9) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.43
In every case, GDNF and NGF (except 1 ng/ml NGF) supplementation significantly enhanced CAP-evoked CGRP release over the same concentration of BDNF (Fig 8A).
Positive_regulation (enhanced) of CAP associated with qutenza, nerve growth factor and calcitonin gene-related peptide
10) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.42
In accordance with this increased CAP sensitivity, NGF increases the expression of the CAP- and noxious heat-sensitive ion channel vanilloid receptor type 1 (TRPV1) through the ras/p38 MAP kinase signaling pathway, thereby promoting thermal hyperalgesia [25,26].
Positive_regulation (increased) of CAP associated with nerve growth factor, qutenza and thermal hyperalgesia
11) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.84 Pain Relevance 1.37
In this case, NGF treatment still significantly increased CAP-evoked CGRP release over no growth factor treatment at 1, 10 and 100 ng/ml.
Positive_regulation (increased) of CAP associated with qutenza, nerve growth factor and calcitonin gene-related peptide
12) Confidence 0.02 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.49
Because increased CAP amplitude is typically interpreted as a recruitment of more axons, a stimulus-output plateau suggests that all available axons have been recruited.
Positive_regulation (increased) of CAP
13) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.82 Pain Relevance 0.23
A further CAP increase could potentially arise from a change in the total number of axons; however, after SNE the numbers of large- and small-diameter afferents do not change proximal to the injury site, where the recorded tissues were sampled [22].
Positive_regulation (increase) of CAP in proximal associated with injury and nerve compression syndromes
14) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.81 Pain Relevance 0.21
It is notable that increased A- and C-fiber CAP amplitudes persisted even after the stimulus-output plot reached a plateau (Fig. 1).
Positive_regulation (increased) of CAP associated with c fibre
15) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 1.05 Pain Relevance 0.27
Much larger increases in CAP TTX-resistance, and only in C-fibers (resistant to block by 100 ?
Positive_regulation (increases) of CAP associated with c fibre
16) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.88 Pain Relevance 0.86
It is therefore more likely that the observed CAP increase represents peripherally increased Na+ conductance in individual axons.
Positive_regulation (increase) of CAP
17) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.73 Pain Relevance 0.14
We found that SNE injury in rats induced a unique electrophysiological phenotype characterized by increased sciatic nerve CAP amplitude in both C- and A-fiber populations (Fig. 1).
Positive_regulation (increased) of CAP in sciatic nerve associated with injury, nerve compression syndromes and sciatic nerve
18) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 1.26 Pain Relevance 0.58

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