INT74840

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Context Info
Confidence 0.00
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.24
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cacna1a, Cacna1a) cytoplasm (Cacna1a, Cacna1a) cell death (Cacna1a, Cacna1a)
nucleus (Cacna1a, Cacna1a) plasma membrane (Cacna1a, Cacna1a) neurological system process (Cacna1a, Cacna1a)
Anatomy Link Frequency
brain 1
Cacna1a (Mus musculus)
Cacna1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 33 100.00 Very High Very High Very High
Calcium channel 4 99.64 Very High Very High Very High
headache 7 79.92 Quite High
Disease Link Frequency Relevance Heat
Migraine With Aura 18 100.00 Very High Very High Very High
Ataxia 13 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 4 100.00 Very High Very High Very High
Hypersensitivity 3 99.76 Very High Very High Very High
Headache 19 97.64 Very High Very High Very High
Pressure And Volume Under Development 1 85.36 High High
Hemiplegia 1 84.76 Quite High
Coma 1 83.76 Quite High
Head Trauma 1 82.08 Quite High
Injury 1 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 18 missense mutations in the CACNA1A gene, which are associated with familial hemiplegic migraine type 1 (FHM1), only mutations S218L, R583Q and T666M were identified in more than two independent families.
FHM1 Binding (associated) of CACNA1A gene associated with migraine with aura and migraine
1) Confidence 0.00 Published 2008 Journal Clin. Genet. Section Abstract Doc Link 18400034 Disease Relevance 0.57 Pain Relevance 0.30
Therefore, we tested the hypothesis that CACNA1A mutations in patients with FHM-1 are associated with hypersensitivity to NO-cGMP pathway.
FHM-1 Binding (associated) of CACNA1A associated with hypersensitivity
2) Confidence 0.14 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18384418 Disease Relevance 0.94 Pain Relevance 0.62
We identified missense mutations in a brain-specific calcium channel alpha1A-subunit (CACNA1A) gene on 19p13 segregating with FHM and truncating mutations in families with episodic ataxia type 2 (EA-2).
FHM Binding (segregating) of CACNA1A in brain associated with ataxia, migraine and calcium channel
3) Confidence 0.06 Published 1998 Journal Neurology Section Abstract Doc Link 9566402 Disease Relevance 1.26 Pain Relevance 0.98
FHM1 is associated with mutations in the CACNA1A gene located on chromosome 19.
FHM1 Binding (associated) of CACNA1A
4) Confidence 0.04 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19438926 Disease Relevance 0.44 Pain Relevance 0.19
Familial hemiplegic migraine type 1, spinocerebellar ataxia type 6 (SCA6) and episodic ataxia type 2 (EA2) are allelic disorders associated with mutations in the CACNA1A gene, which encodes the alpha1 subunit of the P/Q-type calcium channel (Ca(V)2.1).
SCA6 Binding (associated) of CACNA1A gene associated with ataxia, migraine with aura, calcium channel, migraine and spinocerebellar ataxia type 2
5) Confidence 0.01 Published 2007 Journal J. Neurol. Sci. Section Abstract Doc Link 17292920 Disease Relevance 1.02 Pain Relevance 0.26

General Comments

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