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Context Info
Confidence 0.01
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.33
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Cacna1a) plasma membrane (Cacna1a) nucleus (Cacna1a)
neurological system process (Cacna1a) transmembrane transport (Cacna1a) cytoplasm (Cacna1a)
Anatomy Link Frequency
brain 1
Cacna1a (Rattus norvegicus)
Ea2 (Mus musculus)
Pain Link Frequency Relevance Heat
Migraine 17 100.00 Very High Very High Very High
Calcium channel 4 99.64 Very High Very High Very High
headache 2 60.56 Quite High
Disease Link Frequency Relevance Heat
Migraine With Aura 12 100.00 Very High Very High Very High
Ataxia 12 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 4 99.40 Very High Very High Very High
Headache 7 75.00 Quite High
Vertigo 2 61.44 Quite High
Frailty 1 37.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Familial hemiplegic migraine type 1, spinocerebellar ataxia type 6 (SCA6) and episodic ataxia type 2 (EA2) are allelic disorders associated with mutations in the CACNA1A gene, which encodes the alpha1 subunit of the P/Q-type calcium channel (Ca(V)2.1).
CACNA1A gene Binding (associated) of EA2 associated with ataxia, migraine with aura, calcium channel, migraine and spinocerebellar ataxia type 2
1) Confidence 0.01 Published 2007 Journal J. Neurol. Sci. Section Abstract Doc Link 17292920 Disease Relevance 1.02 Pain Relevance 0.26
We identified missense mutations in a brain-specific calcium channel alpha1A-subunit (CACNA1A) gene on 19p13 segregating with FHM and truncating mutations in families with episodic ataxia type 2 (EA-2).
CACNA1A Binding (segregating) of EA-2 in brain associated with ataxia, migraine and calcium channel
2) Confidence 0.00 Published 1998 Journal Neurology Section Abstract Doc Link 9566402 Disease Relevance 1.32 Pain Relevance 1.01

General Comments

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