INT74865

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Context Info
Confidence 0.22
First Reported 1998
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 8.95
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilage 1
proximal 1
thymocytes 1
apoptotic cells 1
band 1
Igh-Dex (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 971 100.00 Very High Very High Very High
Inflammation 125 99.38 Very High Very High Very High
Paracetamol 12 96.00 Very High Very High Very High
Pain 6 94.00 High High
antagonist 1 78.28 Quite High
corticosteroid 8 50.00 Quite Low
chemokine 8 41.84 Quite Low
cytokine 48 41.36 Quite Low
cINOD 11 39.12 Quite Low
Potency 1 18.36 Low Low
Disease Link Frequency Relevance Heat
Cancer 277 99.84 Very High Very High Very High
Death 31 99.44 Very High Very High Very High
INFLAMMATION 139 99.38 Very High Very High Very High
Pancreatic Cancer 205 98.76 Very High Very High Very High
Apoptosis 310 98.72 Very High Very High Very High
Toxicity 8 96.36 Very High Very High Very High
Pressure And Volume Under Development 5 94.84 High High
Pain 5 94.00 High High
Hepatotoxicity 4 90.96 High High
Vomiting 20 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression in cells grown on the polymer–Dex–Dox films (Figure 3B).


Gene_expression (expression) of Dex associated with dexamethasone
1) Confidence 0.22 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.67 Pain Relevance 0.69
Dex incorporation and release from the deposited polymer–Dex–Dox thin films was monitored via the inflammation of cells grown on the polymer–Dex–Dox films with LPS followed by quantitative RT-PCR trials to examine the Dex-mediated suppression of IL-6 and TNF?
Gene_expression (films) of Dex associated with inflammation and dexamethasone
2) Confidence 0.22 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.32 Pain Relevance 0.66
The polymer–Dex–Dox and polymer–Dox hybrids produced enlarged cellular morphologies that were indicative of pre-apoptotic cells.
Gene_expression (produced) of Dex in apoptotic cells associated with apoptosis and dexamethasone
3) Confidence 0.22 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.64 Pain Relevance 0.23
Dex incorporation and release from the deposited polymer–Dex–Dox thin films was monitored via the inflammation of cells grown on the polymer–Dex–Dox films with LPS followed by quantitative RT-PCR trials to examine the Dex-mediated suppression of IL-6 and TNF?
Spec (examine) Gene_expression (suppression) of Dex-mediated associated with inflammation and dexamethasone
4) Confidence 0.22 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.37 Pain Relevance 0.72
Generation of apo-MT with Dex may offer more protection than Zn-MT.
Gene_expression (Generation) of Dex associated with dexamethasone
5) Confidence 0.11 Published 1998 Journal Toxicology Section Abstract Doc Link 9570328 Disease Relevance 0.44 Pain Relevance 0.82
DEX was used in concentrations of 0.1, 1 and 10 ?
Gene_expression (used) of DEX associated with dexamethasone
6) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.63 Pain Relevance 0.38
To examine the ex vivo effect of DEX we isolated tumour cells from pancreatic cancer specimen immediately after resection.
Spec (examine) Gene_expression (effect) of DEX associated with cancer, pancreatic cancer and dexamethasone
7) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.73 Pain Relevance 0.40
ACBC: has been intellectually involved in studying mechanisms of DEX-induced resistance and in preparation of the manuscript
Gene_expression (mechanisms) of DEX associated with dexamethasone
8) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.64 Pain Relevance 0.16
DEX and similar GCs were first introduced to tumour therapy on the basis of pro-apoptotic effects in lymphoid cells and on their effectiveness in treating tumour related edema, inflammation, pain, and electrolyte imbalance as well as stimulating appetite, and most importantly, preventing nausea and emesis caused by cytotoxic drugs [4-8].
Gene_expression (introduced) of DEX associated with pain, pressure and volume under development, inflammation, cancer, vomiting, apoptosis and dexamethasone
9) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.96 Pain Relevance 0.29
Cells were treated in vitro or ex vivo with gemcitabine or cisplatin in the presence or absence of DEX.
Neg (absence) Gene_expression (absence) of DEX associated with dexamethasone
10) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.55 Pain Relevance 0.21
Significance testing with one-Way ANOVA analysis identified probe sets differentially expressed between DEX and vehicle-treated cultures over the entire time course (Figure 1C, left panel).
Gene_expression (expressed) of DEX associated with dexamethasone
11) Confidence 0.06 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.06 Pain Relevance 0.19
We examined the proximal promoter regions of three separate gene lists, the top 100 DEX-responsive transcripts generated by GSEA analysis (Figure 5), the 22 091 probe sets deemed expressed in primary chondrocyte cultures and the 1158 transcripts deemed differentially expressed between DEX and vehicle treated cultures by one-Way ANOVA.
Gene_expression (expressed) of DEX in proximal associated with dexamethasone
12) Confidence 0.06 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.06 Pain Relevance 0.22
To ensure that our DEX data set was expressing bona fide cartilage markers, we compared the DEX data to our previously generated micromass culture data set [50].
Gene_expression (expressing) of DEX in cartilage associated with dexamethasone
13) Confidence 0.06 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.40
Flow cytometric analysis confirmed our earlier findings in thymocytes showing that GR inactivation compromised Dex-induced cell death in WEHI 7.1 cells while the pro-apoptotic activity of CpdA was unaffected (Fig. 3C,D).
Gene_expression (compromised) of Dex in thymocytes associated with apoptosis, dexamethasone and death
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.88 Pain Relevance 0.20
Out of the 2119 probe sets displaying at least 1.5-fold changes in expression in the micromass culture data set (a probe set list generated from the pair-wise comparison of day 3 versus day 15 of micromass culture), 1730 were also expressed in the DEX array.
Gene_expression (expressed) of DEX associated with dexamethasone
15) Confidence 0.05 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.36
This synergistic effect may be explained by a further increase in lipocalin 2 expression with Dex treatment of transfected cells (45%, P < 0.05).
Gene_expression (expression) of Dex associated with dexamethasone
16) Confidence 0.04 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0 Pain Relevance 0.41
MAIN METHODS: Mice were injected subcutaneously with Dex for 1 or 5 days.
Gene_expression (injected) of Dex
17) Confidence 0.03 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
A single band (34 kDa) corresponding to ApoE was present only in the Dex and AIM treated MSCs (Figure 2b).
Gene_expression (present) of Dex in band associated with dexamethasone
18) Confidence 0.01 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.24

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