INT74866

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.68
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Apo (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 4 99.64 Very High Very High Very High
Paracetamol 12 96.00 Very High Very High Very High
Bile 8 84.48 Quite High
agonist 32 67.24 Quite High
Angina 8 12.32 Low Low
alcohol 23 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 608 100.00 Very High Very High Very High
Targeted Disruption 23 99.88 Very High Very High Very High
Hyperlipidemia 15 97.68 Very High Very High Very High
Toxicity 6 96.36 Very High Very High Very High
Coronary Heart Disease 66 95.64 Very High Very High Very High
Hepatotoxicity 4 90.96 High High
Diabetes Mellitus 52 88.84 High High
Coronary Artery Disease 59 88.04 High High
Atherosclerosis 98 84.16 Quite High
Obesity 27 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation of apo-MT with Dex may offer more protection than Zn-MT.
Positive_regulation (Generation) of Gene_expression (Generation) of apo associated with dexamethasone
1) Confidence 0.49 Published 1998 Journal Toxicology Section Abstract Doc Link 9570328 Disease Relevance 0.44 Pain Relevance 0.82
Phase three: cholesterol ester transfer protein (CETP) mediates exchange of cholesterol esters between HDL-C and Apo B lipoproteins
Positive_regulation (-) of Gene_expression (lipoproteins) of Apo B associated with disorder of lipid metabolism
2) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.48 Pain Relevance 0.04
Heterozygotes with a 40% decrease in CETP levels had a mean increase in HDL-C of 30% and no significant change in LDL-C levels, while homozygotes with complete loss of CETP levels had a greater than 100% increase in HDL-C and 40% decrease in LDL-C and Apo B levels (Inazu et al 1990; Koizumi et al 1991).
Positive_regulation (increase) of Gene_expression (levels) of Apo B associated with disorder of lipid metabolism
3) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.07 Pain Relevance 0.04
Studies on transgenic mice overexpressing human apo A-V showed a decreased level of triglyceride, whereas knock-out mice showed an increased level of triglyceride [3].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of apo associated with targeted disruption
4) Confidence 0.11 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.78 Pain Relevance 0
In a group of 543 healthy, middle-aged men the C genotype was associated with elevated levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B (Apo B).
Positive_regulation (elevated) of Gene_expression (levels) of Apo B associated with disorder of lipid metabolism
5) Confidence 0.01 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.83 Pain Relevance 0.03

General Comments

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