INT7487

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 36
Total Number 39
Disease Relevance 11.08
Pain Relevance 20.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
DRN 4
hippocampus 2
neurons 2
outflow 1
brain 1
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 44 100.00 Very High Very High Very High
Hippocampus 8 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
intrathecal 1 99.98 Very High Very High Very High
agonist 87 99.96 Very High Very High Very High
Intracerebroventricular 2 99.84 Very High Very High Very High
Serotonin 43 99.80 Very High Very High Very High
antidepressant 22 99.68 Very High Very High Very High
noradrenaline 2 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 29 99.88 Very High Very High Very High
Urological Neuroanatomy 181 99.64 Very High Very High Very High
Depression 26 99.24 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 97.88 Very High Very High Very High
Injury 7 97.20 Very High Very High Very High
Hyperalgesia 14 97.10 Very High Very High Very High
Nociception 10 96.92 Very High Very High Very High
Pain 36 95.04 Very High Very High Very High
Stress 23 93.20 High High
Anxiety Disorder 3 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Venlafaxine-induced depression of wind-up activity in mononeuropathic rats is potentiated by inhibition of brain 5-HT1A receptor expression in vivo.
Gene_expression (expression) of 5-HT1A in brain associated with depression
1) Confidence 0.75 Published 2004 Journal Int. J. Neurosci. Section Title Doc Link 14702210 Disease Relevance 0.28 Pain Relevance 0.42
More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of 5-HT1A receptors.
Gene_expression (expression) of 5-HT1A associated with depression
2) Confidence 0.75 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 0.67 Pain Relevance 0.43
Specifically, we detected increase in the expression of 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C and 5-HT4 receptors.
Gene_expression (expression) of 5-HT1A
3) Confidence 0.75 Published 2005 Journal Neuroscience Section Abstract Doc Link 15730869 Disease Relevance 1.28 Pain Relevance 0.48
Furthermore, as well as thermal and mechanical hyperalgesia, CCI caused serotonergic hyperactivity (as shown by the increase of basal activity of serotonergic neurones, extracellular serotonin levels and expression of 5-HT1A receptor gene).
Gene_expression (expression) of 5-HT1A associated with hyperalgesia, eae, attention deficit hyperactivity disorder and serotonin
4) Confidence 0.75 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17040473 Disease Relevance 1.02 Pain Relevance 1.24
Effect of triiodothyronine on 5-HT1A and 5-HT1B receptor expression in rat forebrain and on latency to feed in the novelty suppressed feeding test.
Gene_expression (expression) of 5-HT1A in forebrain
5) Confidence 0.75 Published 2010 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 20206658 Disease Relevance 0.16 Pain Relevance 0.48
The presence of 5-HT1A and 5-HT1B receptors in serotoninergic neurons was assessed using binding assays.
Gene_expression (presence) of 5-HT1A in neurons
6) Confidence 0.75 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10217255 Disease Relevance 0 Pain Relevance 0.22
Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed expression of 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5B, 5-HT6 and 5-HT7 receptor mRNAs in astrocytes derived from 2-day old rats and cultured for 10-12 days.
Gene_expression (expression) of 5-HT1A in astrocytes
7) Confidence 0.75 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9795156 Disease Relevance 0 Pain Relevance 0.14
First, in competition binding experiments at h alpha2A and h5-HT1A receptors expressed in CHO cells, several compounds, including the antagonists 1-(2-pyrimidinyl)piperazine (1-PP), (+/-)-idazoxan, benalfocin (SKF 86466), yohimbine and RX 821,002, displayed preference for h alpha2A versus h5-HT1A receptors of only 1.4-, 3.6-, 4-, 10- and 11-fold, respectively (based on differences in pKi values).
Gene_expression (expressed) of 5-HT1A associated with antagonist
8) Confidence 0.75 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.26
Significant effects of fluoxetine were found on the expression of 5-HT1B receptors in the frontal cortex and of T3 on the expression of 5-HT1A receptors in the amygdala and hippocampus and 5-HT1B receptors in the frontal and entorhinal cortices, the expression being reduced in all cases.
Gene_expression (expression) of 5-HT1A in frontal cortex associated with urological neuroanatomy, hippocampus, amygdala and fluoxetine
9) Confidence 0.75 Published 2010 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 20206658 Disease Relevance 0.18 Pain Relevance 0.63
Antinociceptive effects of inhibiting 5-HT1A receptor expression by intracerebroventricular administration of an antisense oligodeoxynucleotide were studied in mononeuropathic rats.
Gene_expression (expression) of 5-HT1A associated with intracerebroventricular and antinociceptive
10) Confidence 0.75 Published 2004 Journal Int. J. Neurosci. Section Abstract Doc Link 14702210 Disease Relevance 0.24 Pain Relevance 0.30
Polymerase chain reaction amplification of 5-HT receptor cDNA demonstrates that 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A and 5-HT3, but not the 5-HT2C, receptor subtypes are present in lumbar sympathetic ganglia.
Neg (not) Gene_expression (present) of 5-HT1A in sympathetic
11) Confidence 0.75 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562592 Disease Relevance 0.29 Pain Relevance 0.48
In oocytes coexpressing the mu and 5HT1A receptors with GIRK1, stimulation of either receptor resulted in heterologous desensitization of the subsequent response to the other.
Gene_expression (coexpressing) of 5HT1A in oocytes
12) Confidence 0.75 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7822283 Disease Relevance 0 Pain Relevance 0.42
CONCLUSION: We found that intra-DRN injection of a specific 5-HT1A receptor agonist attenuated morphine-induced apoptosis in rat DRN, which may have a key role in morphine tolerance.


Gene_expression (injection) of 5-HT1A in DRN
13) Confidence 0.65 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20736434 Disease Relevance 0.06 Pain Relevance 0
Intrathecal injections of the selective 5-HT1A, 5-HT1B, 5-HT3 receptor antagonists, WAY 100135, SB-224289, and tropisetron, respectively, and the non-specific antagonist methysergide, were given.
Gene_expression (injections) of 5-HT1A associated with antagonist and intrathecal
14) Confidence 0.65 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165284 Disease Relevance 0.17 Pain Relevance 1.13
These results demonstrate that the 5-HT1 receptors mediating sympatho-inhibition on the systemic vasculature of pithed rats resemble the pharmacological profile of the 5-HT1A, 5-HT1B, and 5-HT1D subtypes.
Gene_expression (profile) of 5-HT1A in vasculature
15) Confidence 0.65 Published 2009 Journal Arch Cardiol Mex Section Abstract Doc Link 20361490 Disease Relevance 0 Pain Relevance 0.39
This is an important contribution as activation of 5-HT1A receptors does not improve baroreflex function in rodent models of depression suggesting that the interaction between 5-HT1A receptors and glycinergic neurons may be involved in the aetiology of abnormal vagal control of HR in depression [23].
Gene_expression (receptors) of 5-HT1A in neurons associated with depression
16) Confidence 0.65 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2964734 Disease Relevance 0.62 Pain Relevance 0.20
No significant difference was observed in the relative expression levels of 5-HT1A receptor mRNA in seminal vesicles and in the vasa deferentia.
Gene_expression (expression) of 5-HT1A in seminal vesicles
17) Confidence 0.65 Published 2004 Journal J. Androl. Section Abstract Doc Link 15477361 Disease Relevance 0 Pain Relevance 0.48
The present investigation determined the levels of RGSZ1 in the hypothalamic paraventricular nucleus of rats subjected to four different treatment protocols that produce desensitization of 5-HT1A receptors.
Gene_expression (produce) of 5-HT1A in nucleus
18) Confidence 0.65 Published 2004 Journal Neuroscience Section Abstract Doc Link 15262317 Disease Relevance 0 Pain Relevance 0.17
Here, we examined the subcellular distribution of 5-HT1A receptors in dendrites from nucleus raphe dorsalis (NRD) (autoreceptors) and hippocampus (heteroreceptors) after acute treatment with the antidepressant SSRI, fluoxetine (10 mg/kg, i.p.).
Spec (examined) Gene_expression (distribution) of 5-HT1A in hippocampus associated with antidepressant, hippocampus, ssri, raphe and fluoxetine
19) Confidence 0.65 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15190115 Disease Relevance 0 Pain Relevance 0.61
The 5-HT1A selective agonist 8-OH-DPAT (3 ?
Gene_expression (selective) of 5-HT1A associated with agonist
20) Confidence 0.65 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.22 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox