INT74870

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.50
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
lens 1
adipocytes 1
Apo (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 78 99.72 Very High Very High Very High
dexamethasone 4 99.64 Very High Very High Very High
Inflammation 45 96.36 Very High Very High Very High
Paracetamol 12 96.00 Very High Very High Very High
Potency 5 90.00 High High
Bile 20 84.48 Quite High
noradrenaline 14 78.40 Quite High
Catecholamine 12 60.16 Quite High
alcohol 59 39.48 Quite Low
fibrosis 1 35.64 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1518 100.00 Very High Very High Very High
Obesity 134 99.92 Very High Very High Very High
Targeted Disruption 60 99.88 Very High Very High Very High
Repression 12 98.80 Very High Very High Very High
Diabetes Mellitus 196 98.72 Very High Very High Very High
Sprains And Strains 284 98.64 Very High Very High Very High
Coronary Artery Disease 170 98.16 Very High Very High Very High
Hyperlipidemia 33 97.68 Very High Very High Very High
Toxicity 9 96.36 Very High Very High Very High
Vasculitis 5 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation of apo-MT with Dex may offer more protection than Zn-MT.
Gene_expression (Generation) of apo associated with dexamethasone
1) Confidence 0.75 Published 1998 Journal Toxicology Section Abstract Doc Link 9570328 Disease Relevance 0.44 Pain Relevance 0.82
The hypotriglyceridemic effects of fibrate therapy result from enhanced LL activity and inhibition of Apo CIII gene expression by fibrate-mediated PPAR?
Gene_expression (expression) of Apo
2) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.11 Pain Relevance 0.04
Phase three: cholesterol ester transfer protein (CETP) mediates exchange of cholesterol esters between HDL-C and Apo B lipoproteins
Gene_expression (lipoproteins) of Apo B associated with disorder of lipid metabolism
3) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.48 Pain Relevance 0.04
Heterozygotes with a 40% decrease in CETP levels had a mean increase in HDL-C of 30% and no significant change in LDL-C levels, while homozygotes with complete loss of CETP levels had a greater than 100% increase in HDL-C and 40% decrease in LDL-C and Apo B levels (Inazu et al 1990; Koizumi et al 1991).
Gene_expression (levels) of Apo B associated with disorder of lipid metabolism
4) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.06 Pain Relevance 0.04
Apo AII is produced only by the liver and constitutes 20% of HDL-C protein content.
Gene_expression (produced) of Apo in liver associated with disorder of lipid metabolism
5) Confidence 0.16 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.54 Pain Relevance 0
agonists enhance gene expression of SR BI, Apo AI, Apo AII, LPL, and ABCA1 (Toth 2005).
Gene_expression (expression) of Apo associated with agonist
6) Confidence 0.16 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.62 Pain Relevance 0.26
Apo : apolipoprotein
Gene_expression (apolipoprotein) of Apo associated with disorder of lipid metabolism
7) Confidence 0.16 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.83 Pain Relevance 0
The absence of an unusual allele frequency of SNP3 in type 2 diabetic patients compared to non diabetic subjects, in spite of triglyceride level variation, shows that there is no association between apo A-V SNP3 polymorphism and the presence or absence of diabetes.
Gene_expression (polymorphism) of apo associated with diabetes mellitus
8) Confidence 0.16 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.86 Pain Relevance 0
The dynamic interfacial properties of apo A-V are consistent with the hypothesis that apo A-V impedes triglyceride particle assembly [7].
Gene_expression (properties) of apo
9) Confidence 0.16 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.78 Pain Relevance 0
Studies on transgenic mice overexpressing human apo A-V showed a decreased level of triglyceride, whereas knock-out mice showed an increased level of triglyceride [3].
Gene_expression (overexpressing) of apo associated with targeted disruption
10) Confidence 0.14 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.78 Pain Relevance 0
Because apo-Fur was able to bind to and shift each of the three sodB promoter fragments and because our expression data showed that the ?
Gene_expression (Because) of apo
11) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.07 Pain Relevance 0
This is true of both iron-bound and apo forms of Fur.
Gene_expression (forms) of apo
12) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.35 Pain Relevance 0
Herein, we show that apo regulation is not fully conserved among all strains of H. pylori. apo-Fur dependent changes in sodB expression are not observed under iron deplete conditions in H. pylori strains G27, HPAG1, or J99.
Gene_expression (regulation) of apo associated with sprains and strains
13) Confidence 0.08 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671405 Disease Relevance 0.46 Pain Relevance 0
While H. pylori Fur has been found to repress a set of genes in its iron-bound state, it has also uniquely been found to repress an additional set of genes in the absence of the iron cofactor, i.e. when Fur is in its apo form. apo-Fur regulation involves repression of an iron storage gene and occurs under iron limited conditions [8].
Gene_expression (form) of apo associated with repression
14) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.44 Pain Relevance 0
A 20×/0.70 multi-immersion HC PL Apo lens, a 40×/0.75 oil immersion HCX PL Fluotar lens, and a 63×/0.60-1.40 oil immersion HCX PL Apo lens (Zeiss, Jena, Germany) were used.
Gene_expression (lens) of Apo in lens
15) Confidence 0.05 Published 2010 Journal Eplasty Section Body Doc Link PMC2860220 Disease Relevance 0 Pain Relevance 0
Since the LDL receptor (LDLR) is expressed on adipocytes [8], we investigated its role in the interaction between apoB100 lipoproteins and adipocytes by analyzing apoB100-only mice that expressed the LDLR (Ldlr+/+Apob100/100) or were LDLR-deficient (Ldlr?
Gene_expression (expressed) of Apob100 in adipocytes associated with obesity
16) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.78 Pain Relevance 0.14
In a group of 543 healthy, middle-aged men the C genotype was associated with elevated levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B (Apo B).
Gene_expression (levels) of Apo B associated with disorder of lipid metabolism
17) Confidence 0.02 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.83 Pain Relevance 0.03

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