INT74871

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Context Info
Confidence 0.26
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.80
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mt1) intracellular (Mt1) lysosome (Mt1)
Anatomy Link Frequency
liver 2
body 2
pituitary gland 2
Mt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 98.86 Very High Very High Very High
agonist 18 93.24 High High
dexamethasone 4 25.00 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Serotonin 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
opiate 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 10 99.06 Very High Very High Very High
Disease 190 97.64 Very High Very High Very High
Arrhythmia Under Development 8 97.40 Very High Very High Very High
Hepatotoxicity 4 95.04 Very High Very High Very High
Aging 4 91.88 High High
Disease Progression 4 80.76 Quite High
Cognitive Disorder 70 74.32 Quite High
Virilism 15 69.88 Quite High
Syndrome 2 42.80 Quite Low
Dementia 6 33.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In normally developing mice exposed to increasing amounts of GnRH, there is a decline in MT1 expression in the pituitary gland, but in hpg mice which are not exposed to GnRH, this decline does not occur [22].
Negative_regulation (decline) of Gene_expression (expression) of MT1 in pituitary gland
1) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1249589 Disease Relevance 0.07 Pain Relevance 0
Because MT1 receptor expression in the SCN is decreased it is certainly possible that melatonin will be ineffective as a synchronizing agent although it is possible that a higher dose of melatonin or a more potent melatonin agonist such as ramelteon may be useful.
Negative_regulation (decreased) of Gene_expression (expression) of MT1 associated with agonist
2) Confidence 0.25 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.75 Pain Relevance 0.05
It has been shown that with degeneration of the SCN, the master body clock, there is a decrease in the expression of MT1 receptors so that strength of melatonin as a synchronizing agent is reduced [126].
Negative_regulation (decrease) of Gene_expression (expression) of MT1 in body
3) Confidence 0.25 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.65 Pain Relevance 0
The role of metallothionein (MT) in protecting the liver against paracetamol (PCT) toxicity was investigated in vivo and in vitro in mice lacking expression of MT-1 and MT-2 genes (MT -/-).
Negative_regulation (lacking) of Gene_expression (expression) of MT-1 in liver associated with toxicity and paracetamol
4) Confidence 0.18 Published 1998 Journal Toxicology Section Abstract Doc Link 9570328 Disease Relevance 0.34 Pain Relevance 0.43

General Comments

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