INT7489

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.15
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
nucleus accumbens 4
colon 2
olfactory tubercle 2
small intestine 2
mossy fiber 2
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 25 100.00 Very High Very High Very High
Morphine 22 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
gABA 7 100.00 Very High Very High Very High
narcan 11 99.98 Very High Very High Very High
Glutamate 9 99.80 Very High Very High Very High
antagonist 1 99.74 Very High Very High Very High
Nucleus accumbens 18 99.68 Very High Very High Very High
opiate 2 99.52 Very High Very High Very High
cocaine 9 98.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 2 89.44 High High
Neuropathic Pain 1 62.36 Quite High
Hyperalgesia 1 50.00 Quite Low
Injury 1 50.00 Quite Low
Epilepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of morphine to the incubation medium reduced the basal release of alpha-neoendorphin in both the nucleus accumbens and striatal slices in naive animals, whereas the stimulated release was attenuated in the latter tissue only.
Negative_regulation (reduced) of Localization (release) of alpha-neoendorphin in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.59 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.10
The basal release of alpha-neoendorphin from hippocampal slices of kainic acid-treated rats was decreased after 3, 24 and 72 h following the drug injection by c. 50%.
Negative_regulation (decreased) of Localization (release) of alpha-neoendorphin
2) Confidence 0.59 Published 1992 Journal Neuroscience Section Abstract Doc Link 1465197 Disease Relevance 0.09 Pain Relevance 0.08
Addition of cocaine or amphetamine to the incubation medium (10(-5)-10(-6) M) decreased the basal release of alpha-neoendorphin in the nucleus accumbens slices of naive rats, but it did not change the stimulated release (K+, 57 mM).
Negative_regulation (decreased) of Localization (release) of alpha-neoendorphin in nucleus accumbens associated with nucleus accumbens and cocaine
3) Confidence 0.56 Published 1998 Journal Neuroscience Section Abstract Doc Link 9681945 Disease Relevance 0 Pain Relevance 0.54
The present study describes the distribution and the colocalization of proenkephalin and prodynorphin messenger RNAs (mRNAs) in the colon of rat by in situ hybridization.
Negative_regulation (describes) of Localization (colocalization) of prodynorphin in colon
4) Confidence 0.41 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10507554 Disease Relevance 0 Pain Relevance 0.23
Naloxone blocked the effect of systemic morphine administration on nigral dynorphin B and GABA release, already at a dose of 0.2 mg/kg s.c.
Negative_regulation (blocked) of Localization (release) of dynorphin B associated with gaba, dynorphin, narcan and morphine
5) Confidence 0.36 Published 1996 Journal Brain Res. Section Abstract Doc Link 8963665 Disease Relevance 0 Pain Relevance 2.12
Therefore, in the nucleus accumbens and the olfactory tubercle, the cellular localization of 5-HT2a mRNA was investigated by determining the colocalization of 5-HT2a mRNA with enkephalin mRNA or dynorphin mRNA. 5-HT2a mRNA was found in enkephalinergic as well as dynorphinergic neurons.
Spec (determining) Negative_regulation (determining) of Localization (colocalization) of dynorphin mRNA in olfactory tubercle associated with nucleus accumbens, dynorphin and enkephalin
6) Confidence 0.26 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9390756 Disease Relevance 0 Pain Relevance 0.52
Release of immunoreactive-dynorphin from the isolated guinea-pig small intestine is reduced during peristaltic activity.
Negative_regulation (reduced) of Localization (Release) of immunoreactive-dynorphin in small intestine associated with dynorphin
7) Confidence 0.25 Published 1981 Journal Neurosci. Lett. Section Title Doc Link 6116215 Disease Relevance 0 Pain Relevance 0.22
Pronociceptive gene expression was measured by assessing prodynorphin mRNA and dynorphin peptides on days 2 and 10 after intrathecal c-Fos electroporation.
Negative_regulation (assessing) of Localization (electroporation) of prodynorphin mRNA
8) Confidence 0.17 Published 2003 Journal Anesthesiology Section Body Doc Link 14508329 Disease Relevance 0.06 Pain Relevance 0
NAL, a specific opiate antagonist, completely blocked dynorphin-induced PRL release.
Negative_regulation (blocked) of Localization (release) of dynorphin associated with dynorphin, antagonist, narcan and opiate
9) Confidence 0.15 Published 1981 Journal Endocrinology Section Abstract Doc Link 6111448 Disease Relevance 0 Pain Relevance 0.71
Kainic acid depresses the ex vivo release of dynorphin B and glutamate from rat hippocampal mossy fiber synaptosomes.
Negative_regulation (depresses) of Localization (release) of dynorphin B in mossy fiber associated with glutamate and dynorphin
10) Confidence 0.07 Published 1992 Journal Neurosci. Lett. Section Title Doc Link 1350075 Disease Relevance 0 Pain Relevance 0.42

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