INT749

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Context Info
Confidence 0.75
First Reported 1976
Last Reported 2010
Negated 62
Speculated 6
Reported most in Abstract
Documents 341
Total Number 347
Disease Relevance 224.12
Pain Relevance 77.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
T cells 11
leukocyte 8
dendritic cells 7
B35 7
Reiter 6
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 1302 100.00 Very High Very High Very High
rheumatoid arthritis 220 100.00 Very High Very High Very High
backache 38 99.96 Very High Very High Very High
Inflammation 579 99.76 Very High Very High Very High
imagery 104 99.64 Very High Very High Very High
Arthritis 941 99.54 Very High Very High Very High
spondylitis 58 99.20 Very High Very High Very High
Pain 144 99.12 Very High Very High Very High
psoriasis 37 99.00 Very High Very High Very High
Rheumatism 15 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 1438 100.00 Very High Very High Very High
Low Back Pain 1091 100.00 Very High Very High Very High
Chlamydia Infection 814 100.00 Very High Very High Very High
Seronegative Spondarthritis 799 100.00 Very High Very High Very High
Rheumatoid Arthritis 257 100.00 Very High Very High Very High
Infection 196 100.00 Very High Very High Very High
Targeted Disruption 189 100.00 Very High Very High Very High
Staphylococcus Infection 145 100.00 Very High Very High Very High
Bullous Skin Disease 124 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 61 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HLA-B27 antigen was present in 81.5% patients.
Gene_expression (present) of HLA-B27
1) Confidence 0.75 Published 1997 Journal Vojnosanit Pregl Section Abstract Doc Link 9471825 Disease Relevance 1.09 Pain Relevance 0.08
HLA-B27 antigen was detected in 10 of 16 (62.5 per cent) patients.
Gene_expression (detected) of HLA-B27
2) Confidence 0.75 Published 1993 Journal Indian J Pathol Microbiol Section Abstract Doc Link 8300175 Disease Relevance 0.68 Pain Relevance 0.31
The HLA B27 antigen was detected in 87% of patients with enthesopathy, while 82% had clinical inflammation of the spine.
Gene_expression (detected) of HLA B27 in spine associated with seronegative spondarthritis, inflammation and rheumatic diseases
3) Confidence 0.75 Published 1983 Journal Presse Med Section Abstract Doc Link 6226960 Disease Relevance 2.29 Pain Relevance 0.69
RESULTS: The HLAB27 antigen was detected in 36% of patients undergoing uveitis screening tests.
Gene_expression (detected) of HLAB27
4) Confidence 0.75 Published 2006 Journal N. Z. Med. J. Section Body Doc Link 16532040 Disease Relevance 0.17 Pain Relevance 0
Antineutrophil cytoplasmic antibodies were positive and the HLA-B27 antigen was present.
Gene_expression (present) of HLA-B27
5) Confidence 0.75 Published 1997 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 9587541 Disease Relevance 1.46 Pain Relevance 0.22
HLA-B27 antigen was detected in 83% of 36 patients compared with 5.9% of 118 controls (relative risk 79, corrected Fisher's P = 7.719E-18).
Gene_expression (detected) of HLA-B27
6) Confidence 0.75 Published 1983 Journal Rheumatol. Int. Section Abstract Doc Link 6422532 Disease Relevance 1.11 Pain Relevance 0.21
Initial work in our laboratory has resulted in the production of probes with specificity for HLA-B locus genes and current efforts are directed toward the derivation of B27 allele-specific probes.
Gene_expression (production) of HLA-B
7) Confidence 0.75 Published 1985 Journal Immunol. Rev. Section Abstract Doc Link 2412952 Disease Relevance 0.52 Pain Relevance 0.06
The main line D in the area 9 occurs more frequently in AS patients expressing HLA-B27 antigen than in patients not showing it (p less than 0.01).
Gene_expression (expressing) of HLA-B27 associated with spinal inflammation
8) Confidence 0.75 Published 1985 Journal Acta Anthropogenet Section Abstract Doc Link 3879949 Disease Relevance 0.58 Pain Relevance 0.58
HLA-B27, when expressed in tapasin-deficient cells, forms increased amounts of HLA-B27 homodimers [9].
Gene_expression (expressed) of HLA-B27
9) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.07 Pain Relevance 0
However, HLA-B27 can be expressed efficiently in the absence of tapasin [24], even though it is loaded with a suboptimal peptide cargo [23], suggesting a partial non-reliance on TAP-association for peptide-loading.
Gene_expression (expressed) of HLA-B27
10) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0 Pain Relevance 0
As shown in Figure 2, HLA-B27 was detected in association with TAP, but in significantly reduced amounts compared with mutant KG-1.B27.H114D.D116Y.
Gene_expression (detected) of HLA-B27 in KG-1
11) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.09 Pain Relevance 0
Thus, HLA-B27 molecules expressed in KG-1 dendritic cell-like cells overall display behaviour similar to other MHC class I molecules previously reported in this cell line [19], confirming it as a suitable model for the study of HLA-B27 in dendritic cell-like cells.


Gene_expression (expressed) of HLA-B27 in dendritic cell
12) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0 Pain Relevance 0
We have generated several human alloreactive cytolytic T lymphocyte (CTL) clones specific for HLA B27 expressed on cells of normals or of patients with ankylosing spondylitis (AS).
Gene_expression (expressed) of HLA B27 in CTL associated with seronegative spondarthritis and spinal inflammation
13) Confidence 0.72 Published 1986 Journal Exp. Clin. Immunogenet. Section Abstract Doc Link 2484102 Disease Relevance 0.92 Pain Relevance 0.60
A novel model of bacterially-induced acute anterior uveitis in rats and the lack of effect from HLA-B27 expression.
Gene_expression (expression) of HLA-B27 in anterior associated with uveitis
14) Confidence 0.71 Published 1997 Journal J. Investig. Med. Section Title Doc Link 9250003 Disease Relevance 0.29 Pain Relevance 0.09
The expression of HLA-B27 did not appear to influence the incidence or severity of uveitis in B27+ low copy heterozygous animals.
Gene_expression (expression) of HLA-B27
15) Confidence 0.71 Published 1997 Journal J. Investig. Med. Section Body Doc Link 9250003 Disease Relevance 0.23 Pain Relevance 0
Results showed that HLA-B27 was positive in 19 and negative in 3.
Neg (negative) Gene_expression (negative) of HLA-B27
16) Confidence 0.70 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517085 Disease Relevance 0.44 Pain Relevance 0.44
HLA-B27 was present in 83 of 89 (93.3%) patients tested.
Gene_expression (present) of HLA-B27
17) Confidence 0.70 Published 2003 Journal J. Rheumatol. Section Body Doc Link 12913940 Disease Relevance 0 Pain Relevance 0
The patient was HLA-B27 negative.
Neg (negative) Gene_expression (negative) of HLA-B27
18) Confidence 0.70 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9805189 Disease Relevance 0.71 Pain Relevance 0.09
Other HLA genes and non-HLA genes also play a part in the development of spondyloarthropathies, especially in those who are HLA-B27 negative.
Neg (negative) Gene_expression (negative) of HLA-B27
19) Confidence 0.70 Published 2000 Journal Ann. Acad. Med. Singap. Section Body Doc Link 10976392 Disease Relevance 0 Pain Relevance 0
The presence of the HLA-B27 gene may serve as an aid to diagnosis or prognosis for clinicians.
Gene_expression (presence) of HLA-B27 gene
20) Confidence 0.70 Published 2000 Journal Ann. Acad. Med. Singap. Section Body Doc Link 10976392 Disease Relevance 0 Pain Relevance 0

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