INT7490

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 1998
Negated 4
Speculated 7
Reported most in Abstract
Documents 7
Total Number 15
Disease Relevance 0.14
Pain Relevance 11.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
striatum 12
nucleus accumbens 6
substantia nigra 2
spinal cord 2
basal ganglia 2
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 66 100.00 Very High Very High Very High
cocaine 54 100.00 Very High Very High Very High
Dynorphin 33 100.00 Very High Very High Very High
gABA 22 100.00 Very High Very High Very High
narcan 22 100.00 Very High Very High Very High
Glutamate 15 100.00 Very High Very High Very High
tetrodotoxin 1 99.92 Very High Very High Very High
Nucleus accumbens 57 99.68 Very High Very High Very High
addiction 6 99.56 Very High Very High Very High
tolerance 6 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 2 77.28 Quite High
Epilepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to elucidate the activity of the endogenous prodynorphin system during opiate tolerance and dependence, we investigated the effect of single and repeated morphine administration on the alpha-neoendorphin tissue level, its in vitro release, and the prodynorphin messenger RNA level in the nucleus accumbens and striatum of the rat.
Spec (investigated) Regulation (effect) of Localization (release) of alpha-neoendorphin in striatum associated with nucleus accumbens, addiction, tolerance, opiate and morphine
1) Confidence 0.62 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.02
Modulation of the alpha-neoendorphin release from the lumbar enlargement of the rat spinal cord by various neuroactive compounds was studied in vitro.
Regulation (Modulation) of Localization (release) of alpha-neoendorphin in spinal cord associated with spinal cord
2) Confidence 0.61 Published 1990 Journal Neuropeptides Section Abstract Doc Link 1980349 Disease Relevance 0 Pain Relevance 0.52
Acute and repeated cocaine administration had no effect on alpha-neoendorphin release in both the nucleus accumbens and striatum at 3 and 48 h after drug injection.
Neg (no) Regulation (effect) of Localization (release) of alpha-neoendorphin in nucleus accumbens associated with nucleus accumbens and cocaine
3) Confidence 0.59 Published 1998 Journal Neuroscience Section Abstract Doc Link 9681945 Disease Relevance 0 Pain Relevance 0.54
To elucidate the activity of the endogenous prodynorphin system upon treatment with psychostimulants, we investigated the effect of single and repeated cocaine and amphetamine on the prodynorphin messenger RNA level, the prodynorphin-derived peptide alpha-neoendorphin tissue level, and its in vitro release in the nucleus accumbens and striatum of rats.
Spec (investigated) Regulation (effect) of Localization (release) of alpha-neoendorphin in striatum associated with nucleus accumbens and cocaine
4) Confidence 0.52 Published 1998 Journal Neuroscience Section Abstract Doc Link 9681945 Disease Relevance 0 Pain Relevance 0.28
In the striatum, single morphine administration had no effect on the alpha-neoendorphin tissue level, release of the peptide, and prodynorphin messenger RNA level.
Neg (no) Regulation (effect) of Localization (release) of alpha-neoendorphin in striatum associated with morphine
5) Confidence 0.45 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.45
To elucidate the activity of the endogenous prodynorphin system upon treatment with psychostimulants, we investigated the effect of single and repeated cocaine and amphetamine on the prodynorphin messenger RNA level, the prodynorphin-derived peptide alpha-neoendorphin tissue level, and its in vitro release in the nucleus accumbens and striatum of rats.
Spec (investigated) Regulation (effect) of Localization (release) of prodynorphin messenger RNA in striatum associated with nucleus accumbens and cocaine
6) Confidence 0.38 Published 1998 Journal Neuroscience Section Abstract Doc Link 9681945 Disease Relevance 0 Pain Relevance 0.28
No significant changes in the basal or K(+)-stimulated alpha-neoendorphin release from hippocampal slices of pentetrazole-treated rats were found at any time points measured.
Neg (No) Regulation (changes) of Localization (release) of alpha-neoendorphin
7) Confidence 0.27 Published 1992 Journal Neuroscience Section Abstract Doc Link 1465197 Disease Relevance 0.14 Pain Relevance 0.07
Naloxone blocked the effect of systemic morphine administration on nigral dynorphin B and GABA release, already at a dose of 0.2 mg/kg s.c.
Regulation (effect) of Localization (release) of dynorphin B associated with gaba, dynorphin, narcan and morphine
8) Confidence 0.22 Published 1996 Journal Brain Res. Section Abstract Doc Link 8963665 Disease Relevance 0 Pain Relevance 2.12
Effect of morphine on dynorphin B and GABA release in the basal ganglia of rats.
Regulation (Effect) of Localization (release) of dynorphin B in basal ganglia associated with gaba, dynorphin, narcan and morphine
9) Confidence 0.22 Published 1996 Journal Brain Res. Section Title Doc Link 8963665 Disease Relevance 0 Pain Relevance 1.61
In vivo microdialysis was used to study the effects of systemic, as well as intracerebral administration of morphine and naloxone on dynorphin B release in neostriatum and substantia nigra of rats.
Regulation (effects) of Localization (release) of dynorphin B in substantia nigra associated with dynorphin, substantia nigra, narcan and morphine
10) Confidence 0.22 Published 1996 Journal Brain Res. Section Abstract Doc Link 8963665 Disease Relevance 0 Pain Relevance 1.08
In order to elucidate the activity of the endogenous prodynorphin system during opiate tolerance and dependence, we investigated the effect of single and repeated morphine administration on the alpha-neoendorphin tissue level, its in vitro release, and the prodynorphin messenger RNA level in the nucleus accumbens and striatum of the rat.
Spec (investigated) Regulation (effect) of in nucleus accumbens Localization (release) of alpha-neoendorphin in striatum associated with nucleus accumbens, addiction, tolerance, opiate and morphine
11) Confidence 0.21 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.02
Acute and repeated cocaine administration had no effect on alpha-neoendorphin release in both the nucleus accumbens and striatum at 3 and 48 h after drug injection.
Neg (no) Regulation (effect) of in striatum Localization (release) of alpha-neoendorphin in nucleus accumbens associated with nucleus accumbens and cocaine
12) Confidence 0.20 Published 1998 Journal Neuroscience Section Abstract Doc Link 9681945 Disease Relevance 0 Pain Relevance 0.54
To elucidate the activity of the endogenous prodynorphin system upon treatment with psychostimulants, we investigated the effect of single and repeated cocaine and amphetamine on the prodynorphin messenger RNA level, the prodynorphin-derived peptide alpha-neoendorphin tissue level, and its in vitro release in the nucleus accumbens and striatum of rats.
Spec (investigated) Regulation (effect) of in nucleus accumbens Localization (release) of alpha-neoendorphin in striatum associated with nucleus accumbens and cocaine
13) Confidence 0.18 Published 1998 Journal Neuroscience Section Abstract Doc Link 9681945 Disease Relevance 0 Pain Relevance 0.28
To elucidate the activity of the endogenous prodynorphin system upon treatment with psychostimulants, we investigated the effect of single and repeated cocaine and amphetamine on the prodynorphin messenger RNA level, the prodynorphin-derived peptide alpha-neoendorphin tissue level, and its in vitro release in the nucleus accumbens and striatum of rats.
Spec (investigated) Regulation (effect) of in nucleus accumbens Localization (release) of prodynorphin messenger RNA in striatum associated with nucleus accumbens and cocaine
14) Confidence 0.13 Published 1998 Journal Neuroscience Section Abstract Doc Link 9681945 Disease Relevance 0 Pain Relevance 0.28
This experiment examined the effects of intracerebroventricularly (i.c.v.) administered kainic acid (KA) on the subsequent ex vivo release of L-glutamate (Glu) and dynorphin B-like immunoreactivity (Dyn B-LI) from isolated rat hippocampal mossy fiber (MF) synaptosomes at 4.5 h, 20 h or 48 h after administration of 0.5 microgram/microliter KA.
Spec (examined) Regulation (effects) of Localization (release) of dynorphin B in mossy fiber associated with glutamate and dynorphin
15) Confidence 0.06 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1350075 Disease Relevance 0 Pain Relevance 0.25

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