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Context Info
Confidence 0.35
First Reported 1998
Last Reported 1999
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.73
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
narcan 3 99.84 Very High Very High Very High
opioid receptor 1 97.64 Very High Very High Very High
aspirin 7 93.88 High High
cytokine 8 90.28 High High
dexamethasone 5 89.52 High High
cINOD 3 63.84 Quite High
Inflammation 2 59.68 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 70.16 Quite High
Cancer 2 69.80 Quite High
Syndrome 1 61.60 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 60.88 Quite High
Infection 1 60.04 Quite High
INFLAMMATION 3 59.68 Quite High
Immune System Diseases 1 54.52 Quite High
Opportunistic Infections 1 49.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1beta caused a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in IkappaB-alpha levels, an inhibitor of NF-kappaB, as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha.
Negative_regulation (decrease) of Negative_regulation (inhibitor) of NF-kappaB
1) Confidence 0.35 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.36 Pain Relevance 0.71
Furthermore unlike the augmentation which was naloxone reversible, the inhibition of NF kappa B by morphine was not reversed by naloxone, suggesting the involvement of a nonclassical opioid receptor.
Neg (not) Negative_regulation (reversed) of Negative_regulation (inhibition) of NF kappa B associated with narcan, opioid receptor and morphine
2) Confidence 0.02 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571161 Disease Relevance 0.37 Pain Relevance 0.94

General Comments

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