INT74937

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Context Info
Confidence 0.18
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.13
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) aging (IL1B)
cytoplasm (CPOX) cell-cell signaling (IL1B) cytosol (IL1B)
Anatomy Link Frequency
HMSM 1
IL1B (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
dexamethasone 1 99.00 Very High Very High Very High
cINOD 17 95.64 Very High Very High Very High
COX-2 inhibitor 2 86.16 High High
antagonist 1 54.28 Quite High
COX2 6 25.00 Low Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Periodontitis 3 97.36 Very High Very High Very High
Ulcers 4 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COX-2 is induced after cellular activation (i.e., by inflammatory cytokines such as IL-1beta).
IL-1beta Positive_regulation (induced) of COX associated with inflammation and cytokine
1) Confidence 0.18 Published 2003 Journal J. Periodontol. Section Abstract Doc Link 14974816 Disease Relevance 0.47 Pain Relevance 0.28
IL-1beta stimulated release of PGE(2) by HMSM cells and increased COX-2 and mPGES-1 mRNA and protein expression.
IL-1beta Positive_regulation (increased) of COX in HMSM
2) Confidence 0.18 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.05 Pain Relevance 0.13
IL-1 beta induced COX-2 but not COX-1 protein.
IL-1 Positive_regulation (induced) of COX
3) Confidence 0.10 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.24 Pain Relevance 0.36
IL-1 beta induced COX-2 but not COX-1 protein.
IL-1 Positive_regulation (induced) of COX
4) Confidence 0.10 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.24 Pain Relevance 0.36
Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.
IL-1beta Positive_regulation (induced) of COX associated with dexamethasone
5) Confidence 0.02 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.13 Pain Relevance 0.41

General Comments

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