INT74944

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 17.69
Pain Relevance 6.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HGF) extracellular space (HGF) extracellular region (HGF)
cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 28
hepatocyte 10
fibroblasts 9
smooth muscle cells 4
head 3
HGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 109 100.00 Very High Very High Very High
COX2 10 100.00 Very High Very High Very High
pulpitis 2 100.00 Very High Very High Very High
rheumatoid arthritis 143 99.84 Very High Very High Very High
diabetic neuropathy 10 98.68 Very High Very High Very High
cINOD 59 98.44 Very High Very High Very High
ischemia 14 98.00 Very High Very High Very High
cOX1 5 97.72 Very High Very High Very High
peripheral neuropathy 5 97.52 Very High Very High Very High
unmyelinated 5 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 12 100.00 Very High Very High Very High
Pulpitis 2 100.00 Very High Very High Very High
Rheumatoid Arthritis 143 99.84 Very High Very High Very High
Keloid Scars 28 99.54 Very High Very High Very High
Cancer 410 99.44 Very High Very High Very High
Diabetes Mellitus 25 99.28 Very High Very High Very High
Diabetic Neuropathy 10 98.68 Very High Very High Very High
Neuropathic Pain 15 98.40 Very High Very High Very High
INFLAMMATION 186 98.32 Very High Very High Very High
Stroke 23 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats.
Positive_regulation (transfer) of Gene_expression (transfer) of hepatocyte growth factor in hepatocyte associated with diabetic neuropathy
1) Confidence 0.70 Published 2005 Journal Diabetes Section Title Doc Link 15734864 Disease Relevance 0.81 Pain Relevance 0.29
The density of endoneurial capillaries, disclosing marked reduction in diabetic rats, was also reversed significantly by repeated gene transfer of HGF; however, no considerable differences were observed morphometrically in either myelinated or unmyelinated axons.
Positive_regulation (transfer) of Gene_expression (transfer) of HGF in HGF associated with diabetes mellitus and unmyelinated
2) Confidence 0.70 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.73 Pain Relevance 0.30
These results suggest that nonviral HVJ liposome-mediated gene transfer of human HGF has potential for the safe effective treatment of diabetic sensorimotor neuropathy.
Positive_regulation (transfer) of Gene_expression (transfer) of HGF in HGF associated with diabetes mellitus and neuropathic pain
3) Confidence 0.70 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.81 Pain Relevance 0.26
All these changes were significantly reversed by repeated gene transfer of HGF.
Positive_regulation (transfer) of Gene_expression (transfer) of HGF in HGF
4) Confidence 0.70 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.80 Pain Relevance 0.32
HGF expression is induced by PGs in gastric fibroblasts.
Positive_regulation (induced) of Gene_expression (expression) of HGF in fibroblasts
5) Confidence 0.69 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12925150 Disease Relevance 0.19 Pain Relevance 0.18
Exogenous PGs significantly increased HGF production in a dose-dependent manner.
Positive_regulation (increased) of Gene_expression (production) of HGF in HGF
6) Confidence 0.69 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.25 Pain Relevance 0.36
Nonsteroidal anti-inflammatory drugs may delay the repair of gastric mucosa by suppressing prostaglandin-mediated increase of hepatocyte growth factor production.
Positive_regulation (increase) of Gene_expression (production) of hepatocyte growth factor in hepatocyte associated with inflammation and cinod
7) Confidence 0.69 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9571196 Disease Relevance 0.28 Pain Relevance 0.48
In the mature tooth, HGF expression by fibroblasts is enhanced in pulpitis and mediated through the induction of prostaglandin (PG) E(2); it is induced not only by inflammatory cytokines, but also by components of oral bacteria.
Positive_regulation (enhanced) of Gene_expression (expression) of HGF in fibroblasts associated with inflammation, pulpitis and cytokine
8) Confidence 0.58 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 14596869 Disease Relevance 0.50 Pain Relevance 0.23
In the mature tooth, HGF expression by fibroblasts is enhanced in pulpitis and mediated through the induction of prostaglandin (PG) E(2); it is induced not only by inflammatory cytokines, but also by components of oral bacteria.
Positive_regulation (mediated) of Gene_expression (expression) of HGF in fibroblasts associated with inflammation, pulpitis and cytokine
9) Confidence 0.58 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 14596869 Disease Relevance 0.51 Pain Relevance 0.23
In this study, we investigated the effects of cytokines, growth factors, and IND on production of PG and HGF, and induction of COX using cultured human gastric fibroblasts.
Positive_regulation (induction) of Gene_expression (production) of HGF in HGF associated with cytokine
10) Confidence 0.50 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.26 Pain Relevance 0.37
In this study, we gave repeated intramuscular injections of the human hepatocyte growth factor (HGF) gene percutaneously, using liposomes containing the hemagglutinating virus of Japan (HVJ), to examine therapeutic efficacy of nonviral gene transfer of HGF for experimental diabetic sensorimotor neuropathy in rats.
Spec (examine) Positive_regulation (transfer) of Gene_expression (transfer) of HGF in HGF associated with diabetes mellitus and neuropathic pain
11) Confidence 0.47 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.80 Pain Relevance 0.30
IND significantly reduced both basal and IL-1 beta-induced PGE2 release and HGF production.
Positive_regulation (induced) of Gene_expression (production) of HGF in HGF
12) Confidence 0.46 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.23 Pain Relevance 0.36
Expression levels of known MSC immune-modulatory molecules such as IDO, HGF and COX2 generated PGE2 differed in culture supernatants of both the MSCs (Figure 5).
Positive_regulation (generated) of Gene_expression (Expression) of HGF in HGF associated with cox2
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.37 Pain Relevance 0.32
Although the present data are conducted to demonstrate the safety as phase I/early phase IIa, the initial clinical outcome with HGF gene transfer seems to indicate usefulness as sole therapy for CLI.
Positive_regulation (transfer) of Gene_expression (transfer) of HGF in HGF associated with ischemia
14) Confidence 0.42 Published 2004 Journal Hypertension Section Abstract Doc Link 15238569 Disease Relevance 0.73 Pain Relevance 0.27
This effect was reproduced in rats transfected intravenously with the human HGF gene seven days after the instillation of elastase (Shigemura et al 2005).
Positive_regulation (transfected) of Gene_expression (transfected) of HGF in HGF
15) Confidence 0.42 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.53 Pain Relevance 0
AIMS: To evaluate gastric fibroblasts' expression of hepatocyte growth factor (HGF), which is known to facilitate gastric ulcer healing, in the presence of H. pylori; to compare the effect on H. pylori-induced HGF expression of a COX-2 selective inhibitor with that of nonselective nonsteroidal anti-inflammatory drugs
Positive_regulation (pylori-induced) of Gene_expression (expression) of HGF in HGF
16) Confidence 0.40 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807402 Disease Relevance 0.27 Pain Relevance 0
Prostaglandins increased hepatocyte growth factor production significantly in a dose- and time-dependent manner.
Positive_regulation (increased) of Gene_expression (production) of hepatocyte growth factor in hepatocyte
17) Confidence 0.39 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.48 Pain Relevance 0.23
Intramuscular injection of hepatocyte growth factor plasmid once on day 10 following surgery, produced significant augmentation of collateral vessel development in the ischemic limb on day 30.
Positive_regulation (injection) of Gene_expression (injection) of hepatocyte growth factor in hepatocyte
18) Confidence 0.34 Published 2005 Journal Expert Rev Cardiovasc Ther Section Abstract Doc Link 15889978 Disease Relevance 0.49 Pain Relevance 0.12
The study shows that serum HGF levels during the early stage of AMI increased significantly and peaked by day 7 after the onset, at which time there was a strong correlation with peak CRP levels.
Positive_regulation (increased) of Gene_expression (levels) of HGF in HGF associated with myocardial infarction
19) Confidence 0.33 Published 2002 Journal Circ. J. Section Abstract Doc Link 11922273 Disease Relevance 0.61 Pain Relevance 0.26
Extracts from ischemic rat brain have induced the production of BDNF, bFGF, VEGF and HGF in human MSCs in culture [73].
Positive_regulation (induced) of Gene_expression (production) of HGF in HGF
20) Confidence 0.28 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.69 Pain Relevance 0.10

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