INT74946

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 6.29
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HGF) extracellular space (HGF) extracellular region (HGF)
cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 18
hepatocyte 8
fibroblasts 2
HGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 35 99.98 Very High Very High Very High
dexamethasone 2 99.54 Very High Very High Very High
COX2 8 98.60 Very High Very High Very High
cOX1 7 98.60 Very High Very High Very High
unmyelinated 2 96.24 Very High Very High Very High
Thermal hyperalgesia 2 91.84 High High
Brush evoked pain 2 90.44 High High
cytokine 5 85.04 High High
diabetic neuropathy 4 75.00 Quite High
Pain 7 71.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 26 99.86 Very High Very High Very High
Colon Cancer 6 99.82 Very High Very High Very High
Diabetes Mellitus 10 99.68 Very High Very High Very High
Ulcers 10 99.64 Very High Very High Very High
Cancer 107 96.36 Very High Very High Very High
Peptic Ulcer 2 92.44 High High
Hyperalgesia 2 91.84 High High
Toxicity 3 91.04 High High
Targeted Disruption 1 90.64 High High
Neuropathic Pain 6 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, NSAIDs may delay the healing of gastric mucosal ulcer, in part through suppression of HGF expression via inhibition of endogenous PG production.
Negative_regulation (suppression) of Gene_expression (expression) of HGF in HGF associated with ulcers and cinod
1) Confidence 0.58 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.31 Pain Relevance 0.34
IND significantly reduced both basal and IL-1 beta-induced PGE2 release and HGF production.
Negative_regulation (reduced) of Gene_expression (production) of HGF in HGF
2) Confidence 0.58 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.23 Pain Relevance 0.36
Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression.
Negative_regulation (suppression) of Gene_expression (expression) of hepatocyte growth factor in hepatocyte associated with inflammation, colon cancer and cinod
3) Confidence 0.56 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10082276 Disease Relevance 0.53 Pain Relevance 0.38
In the present study, we tested the hypothesis that nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor expression through an endogenous prostaglandin-mediated pathway in cultured human colonic fibroblasts.
Negative_regulation (inhibit) of Gene_expression (expression) of hepatocyte growth factor in fibroblasts associated with inflammation and cinod
4) Confidence 0.56 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.49 Pain Relevance 0.26
Nonsteroidal anti-inflammatory drugs may suppress colon carcinogenesis, in part, through the suppression of hepatocyte growth factor expression by inhibiting endogenous prostaglandin production.
Negative_regulation (suppression) of Gene_expression (expression) of hepatocyte growth factor in hepatocyte associated with inflammation and cinod
5) Confidence 0.56 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.32 Pain Relevance 0.17
Nonsteroidal anti-inflammatory drugs may delay the repair of gastric mucosa by suppressing prostaglandin-mediated increase of hepatocyte growth factor production.
Negative_regulation (suppressing) of Gene_expression (production) of hepatocyte growth factor in hepatocyte associated with inflammation and cinod
6) Confidence 0.43 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9571196 Disease Relevance 0.28 Pain Relevance 0.48
All these changes were significantly reversed by repeated gene transfer of HGF.
Negative_regulation (reversed) of Gene_expression (transfer) of HGF in HGF
7) Confidence 0.43 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.81 Pain Relevance 0.33
The density of endoneurial capillaries, disclosing marked reduction in diabetic rats, was also reversed significantly by repeated gene transfer of HGF; however, no considerable differences were observed morphometrically in either myelinated or unmyelinated axons.
Negative_regulation (reversed) of Gene_expression (transfer) of HGF in HGF associated with diabetes mellitus and unmyelinated
8) Confidence 0.43 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.74 Pain Relevance 0.31
We hypothesized that dexamethasone (DEX) may inhibit PG production and HGF expression, thus inhibiting HGF-induced gastric epithelial restitution.
Spec (may) Negative_regulation (inhibit) of Gene_expression (expression) of HGF in HGF associated with dexamethasone
9) Confidence 0.42 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12925150 Disease Relevance 0.18 Pain Relevance 0.18
NSAIDs, if added early during fibroblast aggregation, inhibited HGF/SF production effectively but had no effect at later stages of cell aggregation.
Negative_regulation (inhibited) of Gene_expression (production) of HGF in HGF associated with cinod
10) Confidence 0.41 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16267016 Disease Relevance 0.66 Pain Relevance 0.25
Indomethacin significantly reduced interleukin-1beta-induced prostaglandin E2 release and hepatocyte growth factor production.
Negative_regulation (reduced) of Gene_expression (production) of hepatocyte growth factor in hepatocyte
11) Confidence 0.41 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.43 Pain Relevance 0.22
AIMS: To evaluate gastric fibroblasts' expression of hepatocyte growth factor (HGF), which is known to facilitate gastric ulcer healing, in the presence of H. pylori; to compare the effect on H. pylori-induced HGF expression of a COX-2 selective inhibitor with that of nonselective nonsteroidal anti-inflammatory drugs
Negative_regulation (inhibitor) of Gene_expression (expression) of HGF in HGF
12) Confidence 0.34 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807402 Disease Relevance 0.27 Pain Relevance 0
This clearly contrasts with the cHCC, where HGF-induced growth is absent (data not shown), most likely because of severely reduced c-MET levels.
Negative_regulation (reduced) of Neg (absent) Gene_expression (levels) of HGF in HGF
13) Confidence 0.21 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.33 Pain Relevance 0.03
Thus, inhibition of stromal-produced HGF or the subsequent activation of c-Met signaling via c-Met inhibitors may represent additional approaches to target CSCs [92].


Negative_regulation (inhibition) of Gene_expression (produced) of HGF in HGF
14) Confidence 0.12 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 0.43 Pain Relevance 0
The SF-36 scales are scored on a 0 to
Negative_regulation (scored) of Gene_expression (scales) of SF-36
15) Confidence 0.02 Published 2003 Journal Health Qual Life Outcomes Section Body Doc Link PMC183842 Disease Relevance 0.28 Pain Relevance 0.07

General Comments

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