INT74962

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Context Info
Confidence 0.82
First Reported 1998
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.18
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 35 100.00 Very High Very High Very High
agonist 16 99.92 Very High Very High Very High
Morphine 5 99.80 Very High Very High Very High
Kinase C 2 96.20 Very High Very High Very High
Enkephalin 4 93.36 High High
Immobilon 6 90.16 High High
MU agonist 4 76.32 Quite High
Delta opioid receptors 1 71.04 Quite High
Opioid 1 65.12 Quite High
tolerance 1 53.00 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363.
Phosphorylation (phosphorylation) of delta-opioid receptor associated with opioid receptor and morphine
1) Confidence 0.82 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16135360 Disease Relevance 0 Pain Relevance 0.54
Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor.
Phosphorylation (palmitoylation) of delta opioid receptor associated with agonist and opioid receptor
2) Confidence 0.82 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16595649 Disease Relevance 0 Pain Relevance 0.19
The increase in phosphorylation of the delta-opioid receptor, as well as its desensitization, was not affected by H7, an inhibitor of protein kinase A and protein kinase C, but was drastically reduced by heparin or Zn2+, known to act as G protein-coupled receptor kinase (GRK) inhibitors.
Phosphorylation (phosphorylation) of delta-opioid receptor associated with kinase c and opioid receptor
3) Confidence 0.80 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9572300 Disease Relevance 0 Pain Relevance 0.53
These findings suggest that SNC80-mediated phosphorylation and down-regulation of the human delta-opioid receptor involves other receptor domains in addition to the carboxy terminus.
Spec (suggest) Phosphorylation (phosphorylation) of delta-opioid receptor associated with opioid receptor
4) Confidence 0.71 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12505529 Disease Relevance 0.09 Pain Relevance 0.75
Phosphorylation and desensitization of adenylyl cyclase inhibition paralleled closely and okadaic acid inhibited the resensitization, a result strongly suggesting that phosphorylation of the delta-opioid receptor plays a prominent role in its rapid desensitization.
Phosphorylation (phosphorylation) of delta-opioid receptor associated with opioid receptor
5) Confidence 0.54 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9572300 Disease Relevance 0 Pain Relevance 0.52
G protein independent phosphorylation and internalization of the delta-opioid receptor.
Phosphorylation (phosphorylation) of delta-opioid receptor associated with opioid receptor
6) Confidence 0.39 Published 2009 Journal J. Neurochem. Section Title Doc Link 19344370 Disease Relevance 0.08 Pain Relevance 0.72

General Comments

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