INT74977

Context Info Confidence 0.41 First Reported 1998 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 4.66 Pain Relevance 1.02

cytosol (FGFR1) extracellular region (FGFR1) cytoplasmic membrane-bounded vesicle (FGFR1) plasma membrane (FGFR1) nucleus (FGFR1) cytoplasm (FGFR1)

Anatomy Link Frequency artery 2 blood 1 brain 1 fibroblast 1 FGFR1 (Homo sapiens)

Pain Link Frequency Relevance Heat colic 8 99.48 Substantia nigra 9 97.92 abdominal pain 3 94.84 cINOD 10 85.60 peptic ulcer disease 1 77.48 midbrain 11 50.00 Inflammation 1 48.96 COX-2 inhibitor 1 37.84 imagery 49 5.00 depression 28 5.00

Disease Link Frequency Relevance Heat Aneurism 10 99.80 Ulcers 12 99.58 Ruptured Aneurysm 2 99.52 Abdominal Cramps 8 99.48 Rupture 2 97.64 Cancer 41 96.48 Post-traumatic Stress Disorder 62 96.32 Abdominal Pain 3 94.84 Apoptosis 12 93.48 Ovarian Cancer 63 86.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This report describes a case of a middle-colic artery aneurysm that was associated with SAM.

SAM Binding (associated) of in artery associated with colic and aneurism

1) Confidence 0.41 Published 2009 Journal Surg. Today Section Abstract Doc Link 19198994 Disease Relevance 0.99 Pain Relevance 0.27

A rupture of a middle-colic artery aneurysm was diagnosed by computed tomography, and angiography showed that it may have been associated with SAM.

SAM Binding (associated) of in artery associated with colic, rupture and aneurism

2) Confidence 0.41 Published 2009 Journal Surg. Today Section Abstract Doc Link 19198994 Disease Relevance 0.99 Pain Relevance 0.27

FGFBP1 and FGFR1 interact with fibroblast growth factors FGF1 and FGF2, and it has been suggested that the fibroblast growth factors could serve as the angiogenic switch in human cancer [41–43].

FGFR1 Binding (interact) of in fibroblast associated with cancer

3) Confidence 0.32 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.92 Pain Relevance 0

In experimental models, peptic ulcer healing can also be accelerated by oral administration of basic fibroblast growth factor, which increases angiogenesis in the ulcer bed, or by nitric oxide-releasing compounds, which improve gastric blood flow.

basic fibroblast growth factor Binding (accelerated) of in blood associated with ulcers

4) Confidence 0.13 Published 1998 Journal Am. J. Med. Section Abstract Doc Link 9572320 Disease Relevance 1.15 Pain Relevance 0.38

In addition, the receptor for FGF-20, FGFR1c, is highly expressed by TH-positive neurons in the substantia nigra and is lower in other brain regions (Ohmachi et al., 2003).

FGFR1c Binding (receptor) of in brain associated with substantia nigra

5) Confidence 0.04 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.20 Pain Relevance 0.10

The SAM system holds low-level representations tightly bound to their sensory and affective qualities.

SAM Binding (bound) of

6) Confidence 0.02 Published 2010 Journal Psychol Rev Section Body Doc Link PMC2834572 Disease Relevance 0.41 Pain Relevance 0

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