INT74983

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.71
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ionocytes 1
heart 1
duct 1
sperm 1
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 15 99.84 Very High Very High Very High
depression 4 99.66 Very High Very High Very High
Endep 10 99.36 Very High Very High Very High
tetrodotoxin 124 95.76 Very High Very High Very High
lidocaine 1 95.68 Very High Very High Very High
Migraine 5 95.28 Very High Very High Very High
Nav1.1 10 93.44 High High
Nav1.2 6 91.52 High High
nav1.3 8 89.60 High High
Nav1.6 8 83.84 Quite High
Disease Link Frequency Relevance Heat
Depression 6 99.66 Very High Very High Very High
Stress 1 99.16 Very High Very High Very High
Inflammatory Bowel Disease 10 98.68 Very High Very High Very High
Targeted Disruption 16 93.64 High High
Heart Disease 2 78.80 Quite High
Emergencies 8 76.32 Quite High
Abdominal Pain 1 74.88 Quite High
Headache 6 70.40 Quite High
Pain 5 65.44 Quite High
Poisoning 21 60.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Single-cell RT-PCR detected mRNA for the Na+ alpha-subunit SCN5A in single human intestinal ICC.
Transcription (detected) of Na
1) Confidence 0.41 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12893628 Disease Relevance 0.10 Pain Relevance 0.10
Then, the level of mRNA (SCN9A) encoding I(Na) decreased significantly.
Transcription (level) of Na
2) Confidence 0.35 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883037 Disease Relevance 0 Pain Relevance 0.11
The levels of expression of Na+, K+-ATPase alpha1- and beta1-isoform proteins were also lower in UC patients than in controls, although there were no differences in Na+, K+-ATPase alpha1- and beta1-isoform mRNA levels between the two groups.
Transcription (levels) of Na associated with inflammatory bowel disease
3) Confidence 0.21 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.79 Pain Relevance 0.07
mRNA expression of voltage-gated Na+ channels in human sperm
Transcription (expression) of Na in sperm
4) Confidence 0.19 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.79
From these results, we speculate that AMI may reduce CSD by inhibiting I(Na) and mRNA expression of sodium channels.
Transcription (expression) of Na associated with depression, sodium channel and endep
5) Confidence 0.07 Published 2010 Journal Brain Res. Section Abstract Doc Link 20398637 Disease Relevance 0.51 Pain Relevance 1.11
The answer to the question, whether or not TTXs Na+ channel transcripts and proteins are of any physiological relevance in the normal heart, could help us to better understand basic cardiac excitation phenomena.
Transcription (transcripts) of Na in heart
6) Confidence 0.07 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857368 Disease Relevance 0.22 Pain Relevance 0.51
In mammals, 2 salt taste receptors have been characterized so far: one that is Na+ specific and a second that does not discriminate among Na+, K+, and NH4+ (Stewart et al. 1997; Lindemann 2001).
Neg (not) Transcription (discriminate) of Na
7) Confidence 0.03 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.09 Pain Relevance 0
Polarized distribution of Na+/H+ exchanger isoforms in rabbit collecting duct cells.
Transcription (distribution) of Na in duct
8) Confidence 0.01 Published 1998 Journal Kidney Int. Section Title Doc Link 9573542 Disease Relevance 0 Pain Relevance 0.10
Taken all together, only a portion of gill ionocytes co-expressed the mRNA of zecac, zpmca2, and zncx1b, and Na+-K+-ATPase.


Transcription (expressed) of Na in ionocytes
9) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2140269 Disease Relevance 0 Pain Relevance 0

General Comments

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