INT74983

Context Info Confidence 0.41 First Reported 1998 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 1.71 Pain Relevance 2.79

Anatomy Link Frequency ionocytes 1 heart 1 duct 1 sperm 1 NA (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 15 99.84 depression 4 99.66 Endep 10 99.36 tetrodotoxin 124 95.76 lidocaine 1 95.68 Migraine 5 95.28 Nav1.1 10 93.44 Nav1.2 6 91.52 nav1.3 8 89.60 Nav1.6 8 83.84

Disease Link Frequency Relevance Heat Depression 6 99.66 Stress 1 99.16 Inflammatory Bowel Disease 10 98.68 Targeted Disruption 16 93.64 Heart Disease 2 78.80 Emergencies 8 76.32 Abdominal Pain 1 74.88 Headache 6 70.40 Pain 5 65.44 Poisoning 21 60.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Single-cell RT-PCR detected mRNA for the Na+ alpha-subunit SCN5A in single human intestinal ICC.

Transcription (detected) of Na

1) Confidence 0.41 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12893628 Disease Relevance 0.10 Pain Relevance 0.10

Then, the level of mRNA (SCN9A) encoding I(Na) decreased significantly.

Transcription (level) of Na

2) Confidence 0.35 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883037 Disease Relevance 0 Pain Relevance 0.11

The levels of expression of Na+, K+-ATPase alpha1- and beta1-isoform proteins were also lower in UC patients than in controls, although there were no differences in Na+, K+-ATPase alpha1- and beta1-isoform mRNA levels between the two groups.

Transcription (levels) of Na associated with inflammatory bowel disease

3) Confidence 0.21 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.79 Pain Relevance 0.07

mRNA expression of voltage-gated Na+ channels in human sperm

Transcription (expression) of Na in sperm

4) Confidence 0.19 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.79

From these results, we speculate that AMI may reduce CSD by inhibiting I(Na) and mRNA expression of sodium channels.

Transcription (expression) of Na associated with depression, sodium channel and endep

5) Confidence 0.07 Published 2010 Journal Brain Res. Section Abstract Doc Link 20398637 Disease Relevance 0.51 Pain Relevance 1.11

The answer to the question, whether or not TTXs Na+ channel transcripts and proteins are of any physiological relevance in the normal heart, could help us to better understand basic cardiac excitation phenomena.

Transcription (transcripts) of Na in heart

6) Confidence 0.07 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857368 Disease Relevance 0.22 Pain Relevance 0.51

In mammals, 2 salt taste receptors have been characterized so far: one that is Na+ specific and a second that does not discriminate among Na+, K+, and NH4+ (Stewart et al. 1997; Lindemann 2001).

Neg (not) Transcription (discriminate) of Na

7) Confidence 0.03 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.09 Pain Relevance 0

Polarized distribution of Na+/H+ exchanger isoforms in rabbit collecting duct cells.

Transcription (distribution) of Na in duct

8) Confidence 0.01 Published 1998 Journal Kidney Int. Section Title Doc Link 9573542 Disease Relevance 0 Pain Relevance 0.10

Taken all together, only a portion of gill ionocytes co-expressed the mRNA of zecac, zpmca2, and zncx1b, and Na+-K+-ATPase.

Transcription (expressed) of Na in ionocytes

9) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2140269 Disease Relevance 0 Pain Relevance 0

General Comments

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