INT7499

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.42
Pain Relevance 6.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
plasma 2
arcuate nucleus 2
cleavage 2
dorsal root ganglia 2
stomach 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 66 100.00 Very High Very High Very High
Dopamine 11 100.00 Very High Very High Very High
agonist 9 100.00 Very High Very High Very High
excitatory amino acid 2 100.00 Very High Very High Very High
tetrodotoxin 3 99.84 Very High Very High Very High
diclofenac 1 99.64 Very High Very High Very High
Cholecystokinin 13 99.58 Very High Very High Very High
Analgesic 1 99.26 Very High Very High Very High
Inflammation 2 99.06 Very High Very High Very High
Enkephalin 5 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 99.06 Very High Very High Very High
Inflammatory Pain 2 84.88 Quite High
Hyperalgesia 1 83.40 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of the anti-inflammatory analgesic, sodium diclofenac (3 mg.kg-1.d-1), abolished an adjuvant-induced increase in the content of immunoreactive somatostatin in the dorsal root ganglia.
Negative_regulation (abolished) of Positive_regulation (increase) of somatostatin in dorsal root ganglia associated with inflammation, analgesic, somatostatin and diclofenac
1) Confidence 0.59 Published 1990 Journal Neurosci. Res. Section Abstract Doc Link 1977111 Disease Relevance 0.42 Pain Relevance 1.14
Both SKF 38393 and quinpirole, when given alone, tended to decrease the haloperidol-induced increase in somatostatin levels; when both D1 and D2 agonists were administered together, somatostatin levels declined significantly.
Negative_regulation (decrease) of Positive_regulation (increase) of somatostatin associated with agonist and somatostatin
2) Confidence 0.58 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883854 Disease Relevance 0 Pain Relevance 0.88
The release of somatostatin induced by the excitatory amino acid agonists was not blocked by tetrodotoxin (1 microM), a result suggesting that tetrodotoxin-sensitive, sodium-dependent action potentials are not involved in the effect.
Negative_regulation (blocked) of Positive_regulation (induced) of somatostatin associated with action potential, tetrodotoxin, agonist, somatostatin and excitatory amino acid
3) Confidence 0.56 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2570126 Disease Relevance 0 Pain Relevance 0.98
Vagal stimulation caused a decrease in perfusate pH and an increase of the intraluminal output of gastrin and somatostatin when the stomach was perfused with the dextrane solution pH 5.9.
Negative_regulation (decrease) of Positive_regulation (increase) of somatostatin in stomach associated with somatostatin
4) Confidence 0.40 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1350163 Disease Relevance 0 Pain Relevance 0.41
Metoclopramide (10 mumol/l) blocked the dopamine (1 mumol/l)-induced increase in somatostatin release.
Negative_regulation (blocked) of Positive_regulation (increase) of somatostatin associated with dopamine and somatostatin
5) Confidence 0.38 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 2864381 Disease Relevance 0 Pain Relevance 1.02
DMPP caused lesser, though significant, increases in gastrin (166%) and somatostatin (83%) secretion that were nearly abolished by hexamethonium (84-91%) but were not significantly affected by atropine.
Negative_regulation (abolished) of Positive_regulation (increases) of somatostatin associated with somatostatin
6) Confidence 0.37 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.48
Concentrations of somatostatin in portal venous plasma were significantly increased after CCK administration; the increase in somatostatin was blocked by pretreatment with MK-329.
Negative_regulation (blocked) of Positive_regulation (increase) of somatostatin in plasma associated with somatostatin and cholecystokinin
7) Confidence 0.36 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1357976 Disease Relevance 0 Pain Relevance 0.96
The accumulation of the major cleavage products, as well as the initial cleavage of somatostatin, was strongly inhibited by metal chelators and also by specific inhibitors of endopeptidase-24.11 (EC 3.4.24.11), phosphoramidon and thiorphan.
Negative_regulation (inhibited) of Positive_regulation (accumulation) of somatostatin in cleavage associated with somatostatin
8) Confidence 0.32 Published 1990 Journal Peptides Section Abstract Doc Link 1972574 Disease Relevance 0 Pain Relevance 0.42
To determine if the suppression was mediated by inhibition of GH-releasing hormone (GRH) or stimulation of somatostatin (SRIF), an additional experiment was conducted including 5,7-DHT arcuate nucleus-lesioned animals injected with anti-SRIF.
Negative_regulation (inhibition) of Positive_regulation (stimulation) of somatostatin in arcuate nucleus associated with somatostatin
9) Confidence 0.16 Published 1990 Journal Endocrinology Section Abstract Doc Link 1688789 Disease Relevance 0 Pain Relevance 0.61

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