INT75001

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Context Info
Confidence 0.66
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.23
Pain Relevance 0.48

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oxidoreductase activity (Cyp1b1) endoplasmic reticulum (Cyp1b1)
Anatomy Link Frequency
Mouse 1
liver 1
nucleus 1
Cyp1b1 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 2 95.08 Very High Very High Very High
opiate 2 82.80 Quite High
Morphine 3 82.52 Quite High
Paracetamol 4 81.96 Quite High
Potency 4 72.16 Quite High
palliative 1 60.08 Quite High
Catechol-O-methyltransferase 2 50.96 Quite High
monoamine 1 44.68 Quite Low
Bile 12 5.00 Very Low Very Low Very Low
Nicotine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 341 99.96 Very High Very High Very High
Endometrial Cancer 67 98.92 Very High Very High Very High
Apoptosis 11 85.80 High High
Toxicity 15 85.56 High High
Injury 5 83.60 Quite High
Malignant Neoplastic Disease 8 82.96 Quite High
Hyperplasia 7 79.84 Quite High
Targeted Disruption 20 76.56 Quite High
Carcinoma 14 71.84 Quite High
Hepatotoxicity 5 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In smokers, expression of CYP1A1 (p < 0.05), CYP1B1 (p < 0.001), and CYP2C9 (p < 0.05) was increased (p < 0.05) compared with non-smokers, and there was a trend toward increased expression of CYP3A5 (p = 0.0545; Figure 1); however, the expression of CYP2J2 was significantly (p < 0.05) repressed.
Gene_expression (expression) of CYP1B1 associated with nicotine addiction
1) Confidence 0.66 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.85 Pain Relevance 0
Expression of CYP1A1 (p < 0.01), CYP1B1 (p < 0.001), and CYP2S1 (p < 0.001) was higher in BAL cells from smokers compared with those of nonsmokers (Figure 1), whereas expression of CYP2B6/7 (p < 0.01) and CYP3A5 (p < 0.001) was lower; expression of CYP2A6/7, CYP2E1, CYP2C9, CYP2J2, and FMO5 was not altered.
Gene_expression (Expression) of CYP1B1 associated with nicotine addiction
2) Confidence 0.66 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.66 Pain Relevance 0
Upon translocation into the nucleus, the AHR forms a heterodimer with its nuclear counterpart ARNT (AHR nuclear translocator) and drives gene expression of the AHR-responsible gene family, including CYP1A1 and CYP1B1 (Borlak and Thum 2001).
Gene_expression (expression) of CYP1B1 in nucleus
3) Confidence 0.66 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.37 Pain Relevance 0
This may be due to different experimental approaches because Anttila et al. employed immunohistochemistry, whereas we used a sensitive RT-PCR method determine CYP1A1 and CYP1B1 expression and a fluorometric assay to demonstrate increased activity of the coded enzymes.
Spec (determine) Gene_expression (expression) of CYP1B1
4) Confidence 0.66 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.24 Pain Relevance 0
Mouse lines lacking the P450s CYP1A1, CYP1A2, CYP1B1 and CYP2E1, microsomal epoxide hydrolase (mEH), NADPH:quinone oxidoreductase and the glutathione S-transferase P1 have no deleterious phenotypes, indicating that these enzymes are not required for mammalian development and physiological homeostasis.
Neg (lacking) Gene_expression (lacking) of CYP1B1 in Mouse
5) Confidence 0.62 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11323178 Disease Relevance 0.30 Pain Relevance 0.06
Gene expression of CYP1A1, CYP1B1, CYP2S1, GSTP1, and EPHX1 was induced in bronchoalveolar lavage cells of smokers, whereas expression of CYP2B6/7, CYP3A5, and UGT2A1 was repressed.
Gene_expression (expression) of CYP1B1 associated with nicotine addiction
6) Confidence 0.51 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1665420 Disease Relevance 0.49 Pain Relevance 0
The binding of 3-MC to the aryl hydrocarbon receptor (AHR) forms a AHR/3-MC complex, which upregulates CYP1A1, CYP1A2, and CYP1B1 expression by binding, together with the AHR nuclear translocator (ARNT), to the XREs of these genes [30].
Gene_expression (expression) of CYP1B1
7) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.13 Pain Relevance 0.04
Cytochrome P450 1B1 CYP1B1 is a constitutively expressed and inducible enzyme with a central role in the oxidative metabolism of a wide range of endogenous and exogenous compounds including many carcinogens [52, 53].
Gene_expression (expressed) of CYP1B1
8) Confidence 0.37 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.11 Pain Relevance 0.06
The principal enzymes with polymorphic variants involved in phase I reactions are the following: CYP3A4/5/7, CYP2E1, CYP2D6, CYP2C19, CYP2C9, CYP2C8, CYP2B6, CYP2A6, CYP1B1, CYP1A1/2, epoxide hydrolase, esterases, NQO1 (NADPH-quinone oxidoreductase), DPD (dihydropyrimidine dehydrogenase), ADH (alcohol dehydrogenase), and ALDH (aldehyde dehydrogenase).
Gene_expression (/) of CYP1B1 associated with alcohol
9) Confidence 0.22 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0 Pain Relevance 0.07
In addition to the CYP80B1 alleles, another cytochrome P-450 with an inducible transcript (CYP82B1) was isolated and expressed in the same manner, but was not found to be involved in alkaloid biosynthesis in this plant.
Gene_expression (expressed) of CYP82B1
10) Confidence 0.03 Published 1998 Journal Plant J. Section Abstract Doc Link 9681018 Disease Relevance 0 Pain Relevance 0
Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis.
Gene_expression (expression) of CYP80B1
11) Confidence 0.03 Published 1998 Journal Plant J. Section Title Doc Link 9681018 Disease Relevance 0 Pain Relevance 0.17
Western immunoblotting analyses revealed that ATB treatment (50 mg/kg/day for 5 days) failed to alter cytochrome P4501A2, P4502B1/2 and P4502E1 levels in the liver, whereas the expression of P4502C11 was reduced approximately 50% by ATB. 3.
Gene_expression (levels) of P4501A2 in liver
12) Confidence 0.00 Published 1998 Journal Xenobiotica Section Abstract Doc Link 9574820 Disease Relevance 0.08 Pain Relevance 0.08

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