INT75006

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.19
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gstm1) cytoplasm (Gstm1)
Gstm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
member 8 2 98.56 Very High Very High Very High
Paracetamol 5 97.84 Very High Very High Very High
Glutamate receptor 6 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
carbamazepine 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
GABA receptor 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
antiepileptic Drug 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 50 97.28 Very High Very High Very High
Injury 11 95.92 Very High Very High Very High
Stress 26 95.84 Very High Very High Very High
Hypertension 59 94.32 High High
Insulin Resistance 3 82.68 Quite High
Targeted Disruption 3 80.56 Quite High
Toxicity 14 72.08 Quite High
Pressure Volume 2 Under Development 6 60.80 Quite High
Sprains And Strains 10 59.04 Quite High
Hepatotoxicity 6 35.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This has been ascribed to the well-documented reduced expression of Gstm1 [19, 32, 33].
Gene_expression (expression) of Gstm1
1) Confidence 0.45 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.99 Pain Relevance 0
Well-known candidate genes with reduced expression in SHR include fatty acid translocase (Cd36) and glutathione-S-transferase (Gstm1).
Gene_expression (include) of Gstm1
2) Confidence 0.45 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.49 Pain Relevance 0
Expression profiles for specific examples of genes found in xenobiotic metabolism pathways (Cyp2c11, Cyp2e1, Cyp3a23/3a1, Gstm1, glutathione-s-transferase mu 1; Slc22a8, solute carrier family 22 member 8) and energy metabolism (Phgdh, 3-phosphoglycerate dehydrogenase), which exhibit notable sex and age related differences, are shown in Figure 7.


Gene_expression (Expression) of Gstm1 associated with member 8
3) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.31 Pain Relevance 0.10
Expression profiles for specific examples of genes found in xenobiotic metabolism pathways (Cyp2c11, Cyp2e1, Cyp3a23/3a1, Gstm1, glutathione-s-transferase mu 1; Slc22a8, solute carrier family 22 member 8) and energy metabolism (Phgdh, 3-phosphoglycerate dehydrogenase), which exhibit notable sex and age related differences, are shown in Figure 7.


Gene_expression (Expression) of glutathione-s-transferase mu 1 associated with member 8
4) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.31 Pain Relevance 0.10
Gstm1 gene expression was reduced in SHR compared to WKY at all ages (Fig. 1a).
Gene_expression (expression) of Gstm1 gene
5) Confidence 0.40 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0 Pain Relevance 0
Polymorphisms in glutathione-related genes (glutamate cysteine ligase catalytic subunit (GCLC)-129, glutamate cysteine ligase modifier subunit (GCLM)-588, glutathione S-transferase alpha 1 (GSTA1)-52, GSTM1*O, GSTP1-105, GSTP1-114, and GSTT1*O) were analyzed by Taqman-based allelic discrimination and ordinary PCR.
Gene_expression (-588) of GSTM1
6) Confidence 0.13 Published 2008 Journal Int Arch Occup Environ Health Section Body Doc Link 18066575 Disease Relevance 0 Pain Relevance 0
Partial hepatoprotective effects of allylthiobenzimidazole in the absence of cytochrome P4502E1 suppression: effects on epoxide hydrolase, rGSTA2, rGSTA3/5, rGSTM1 and rGSTM2 expression.
Gene_expression (expression) of rGSTM1
7) Confidence 0.00 Published 1998 Journal Xenobiotica Section Title Doc Link 9574820 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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