INT75014

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Context Info
Confidence 0.06
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.22
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2a1) endoplasmic reticulum (Cyp2a1)
Anatomy Link Frequency
liver 1
kidney 1
Cyp2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 3 93.84 High High
tricyclic antidepressant 1 48.32 Quite Low
sSRI 1 45.92 Quite Low
headache 6 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Rheumatism 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 74 98.68 Very High Very High Very High
Injury 2 95.48 Very High Very High Very High
Cirrhosis 1 86.52 High High
Chronic Renal Failure 1 79.04 Quite High
Toxicity 1 72.88 Quite High
Hepatotoxicity 4 25.00 Low Low
Hypersomnia 87 24.68 Low Low
Apnoea 44 23.84 Low Low
Sleep Disorders 53 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of the extract on serum electrolytes, serum levels of key glucose metabolizing enzymes, hepatic microsomal protein and hepatic cytochrome P-450-dependent mono-oxygenase enzyme systems and lipid peroxidation in the liver and kidney of diabetic rats.
Regulation (effect) of hepatic cytochrome P-450-dependent in kidney associated with diabetes mellitus
1) Confidence 0.06 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Abstract Doc Link PMC2772005 Disease Relevance 0.44 Pain Relevance 0
By comparison, the effects of allylthiobenzimidazole (ATB) on the levels of several hepatic cytochrome P450, microsomal epoxide hydrolase (mEH) and GST expression have been studied in the rat herein. 2.
Regulation (effects) of hepatic cytochrome P450
2) Confidence 0.06 Published 1998 Journal Xenobiotica Section Abstract Doc Link 9574820 Disease Relevance 0.10 Pain Relevance 0.09
Modafinil has the potential to modulate the activities of hepatic cytochrome P450 (CYP) isoenzymes.
Regulation (modulate) of hepatic cytochrome P450
3) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 0.24 Pain Relevance 0
The effect of the extract on serum electrolytes, serum levels of key glucose metabolizing enzymes, hepatic microsomal protein and hepatic cytochrome P-450-dependent mono-oxygenase enzyme systems and lipid peroxidation in the liver and kidney of diabetic rats.
Regulation (effect) of hepatic cytochrome P-450-dependent in liver associated with diabetes mellitus
4) Confidence 0.02 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Abstract Doc Link PMC2772005 Disease Relevance 0.44 Pain Relevance 0

General Comments

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