INT75043

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.36
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Msx1) nucleus (Msx1) DNA binding (Msx1)
Anatomy Link Frequency
cleavage 1
Msx1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 24 95.96 Very High Very High Very High
Enkephalin 7 93.32 High High
Potency 1 82.04 Quite High
melanocortin 1 receptor 32 75.00 Quite High
Somatostatin 9 56.92 Quite High
Central nervous system 30 36.32 Quite Low
Opioid 8 34.40 Quite Low
Dynorphin 2 23.36 Low Low
antagonist 21 17.20 Low Low
cytokine 1 11.68 Low Low
Disease Link Frequency Relevance Heat
Obesity 114 99.52 Very High Very High Very High
Experimental Melanoma 4 99.00 Very High Very High Very High
Appetite Loss 20 96.24 Very High Very High Very High
Weight Gain 8 90.32 High High
Skin Cancer 142 82.04 Quite High
Disease 8 74.28 Quite High
Melanoma 27 72.12 Quite High
Adhesions 3 59.88 Quite High
Metastasis 14 55.00 Quite High
Sunburn 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSH and ACTH bind to receptors that couple to heterotrimeric guanine nucleotide-binding proteins(G proteins) which activate adenylyl cyclise [Figure 1].[117] Using PCR with primers based on conserved areas of other members of 7-transmembrane G protein-linked receptors, Gantz et al.,[118] isolated several genes encoding an ‘orphan’ subfamily of receptors specific for melanocortins.
MSH Binding (bind) of
1) Confidence 0.35 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 0.42 Pain Relevance 0.06
Moreover, TRH also stimulated cAMP production in murine B16 melanoma cells reaching the same maximum level of cAMP as found for alpha-MSH.
MSH Binding (found) of associated with experimental melanoma
2) Confidence 0.10 Published 1999 Journal Peptides Section Abstract Doc Link 10447100 Disease Relevance 0.19 Pain Relevance 0.07
To ensure that our ASIP-YY preparation retained its known inhibitory activity, we evaluated its inhibition of MSH-induced cAMP production in melan-a cells.
MSH Neg (inhibition) Binding (inhibition) of
3) Confidence 0.08 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.05
-MSH, which is also associated with human obesity [40]. ?
MSH Binding (associated) of associated with obesity
4) Confidence 0.03 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.80 Pain Relevance 0.09
-MSH, associated with early-onset human obesity [41,129], as well as a cleavage site mutation preventing processing of POMC to ?
MSH Binding (associated) of in cleavage associated with obesity
5) Confidence 0.03 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.79 Pain Relevance 0.09
Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes.
MSH-B Binding (binding) of
6) Confidence 0.01 Published 1997 Journal Neuropeptides Section Title Doc Link 9574823 Disease Relevance 0.16 Pain Relevance 0.28

General Comments

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