INT75050

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2005
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 0.64
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GHSR) signal transducer activity (GHSR)
Anatomy Link Frequency
stomach 2
MC3 2
GHSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Somatostatin 4 88.00 High High
Potency 4 82.68 Quite High
Central nervous system 2 25.00 Low Low
vagus nerve 2 25.00 Low Low
qutenza 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Experimental Melanoma 8 86.04 High High
Stress 4 25.00 Low Low
Peptic Ulcer 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ghrelin, an acylated peptide produced predominantly by the stomach, has been discovered to be a natural ligand of the growth hormone secretagogue receptor 1a (GHS-R1a).
growth hormone secretagogue receptor Binding (ligand) of in stomach
1) Confidence 0.47 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 16370568 Disease Relevance 0 Pain Relevance 0
Ghrelin, an acylated peptide produced predominantly by the stomach, has been discovered to be a natural ligand of the growth hormone secretagogue receptor 1a (GHS-R1a).
GHS-R1a Binding (ligand) of in stomach
2) Confidence 0.23 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 16370568 Disease Relevance 0 Pain Relevance 0
We determined the binding affinities of the MSH analogues MSH-B, HP-228 and 153N-6 and of the enkephalin analogue GHRP-6 on a single eukaryotic cell line transiently expressing the human MC1, MC3, MC4 and MC5 receptors.
GHRP-6 Spec (determined) Binding (affinities) of in MC3 associated with enkephalin
3) Confidence 0.08 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574823 Disease Relevance 0.16 Pain Relevance 0.14
We determined the binding affinities of the MSH analogues MSH-B, HP-228 and 153N-6 and of the enkephalin analogue GHRP-6 on a single eukaryotic cell line transiently expressing the human MC1, MC3, MC4 and MC5 receptors.
GHRP-6 Spec (determined) Binding (binding) of in MC3 associated with enkephalin
4) Confidence 0.08 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574823 Disease Relevance 0.16 Pain Relevance 0.14
[D-Lys3]GHRP-6 bound to all the four MC receptors with similar affinities.
GHRP-6 Binding (bound) of
5) Confidence 0.08 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574823 Disease Relevance 0.17 Pain Relevance 0.33
Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes.
GHRP-6 Binding (binding) of
6) Confidence 0.07 Published 1997 Journal Neuropeptides Section Title Doc Link 9574823 Disease Relevance 0.16 Pain Relevance 0.28

General Comments

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