INT75053

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Context Info
Confidence 0.53
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 0.41
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC3R) signal transducer activity (MC3R)
Anatomy Link Frequency
brain 3
testis 2
B lymphocytes 1
skin 1
MC3 1
MC3R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 18 99.90 Very High Very High Very High
Enkephalin 3 98.76 Very High Very High Very High
Potency 2 85.52 High High
antagonist 4 75.00 Quite High
agonist 6 47.36 Quite Low
Somatostatin 1 35.28 Quite Low
Disease Link Frequency Relevance Heat
Neuroblastoma 5 93.76 High High
Experimental Melanoma 2 90.16 High High
Alagille Syndrome 1 51.96 Quite High
Syndrome 145 5.00 Very Low Very Low Very Low
Aggression 75 5.00 Very Low Very Low Very Low
Gigantism 25 5.00 Very Low Very Low Very Low
Helminth Infection 20 5.00 Very Low Very Low Very Low
Freckles 20 5.00 Very Low Very Low Very Low
Dwarfism 20 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We determined the binding affinities of the MSH analogues MSH-B, HP-228 and 153N-6 and of the enkephalin analogue GHRP-6 on a single eukaryotic cell line transiently expressing the human MC1, MC3, MC4 and MC5 receptors.
Gene_expression (expressing) of MC3 in MC3 associated with enkephalin
1) Confidence 0.53 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574823 Disease Relevance 0.17 Pain Relevance 0.14
RT-PCR of streptokinase-streptodornase-stimulated PBMCs for all five melanocortin receptors demonstrated MC1R expression by monocytes/macrophages, MC1R and MC3R expression by B lymphocytes, but no melanocortin receptor expression by T lymphocytes.
Gene_expression (expression) of MC3R in B lymphocytes associated with melanocortin 1 receptor
2) Confidence 0.52 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16177130 Disease Relevance 0.05 Pain Relevance 0.88
A number of novel alpha-melanotropin (alpha-MSH) analogues have been designed, synthesized, and assayed for bioactivity at the melanocortin-1 (MC1) receptor from Xenopus frog skin, and selected potent analogues were examined at recombinant human MC1, MC3, and MC4 receptors expressed in human embryonic kidney (HEK) cells.
Gene_expression (expressed) of MC3 in skin
3) Confidence 0.38 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12593660 Disease Relevance 0 Pain Relevance 0.14
We tested differential expression of MC3R and MC4R between island and mainland populations by western blotting of testis and brain lysates (n = 10 males per population) and used lysates from human neuroblastoma cells (SH-SY5Y) as a control.
Gene_expression (expression) of MC3R in brain associated with neuroblastoma
4) Confidence 0.17 Published 2010 Journal BMC Evol Biol Section Body Doc Link PMC2949876 Disease Relevance 0.09 Pain Relevance 0
Western blot analyses showed significant differences in the expression of MC3R and MC4R in the lizards' brain and testes, using actin as an internal standard (Figures 3b and 3c).
Gene_expression (expression) of MC3R in testes
5) Confidence 0.17 Published 2010 Journal BMC Evol Biol Section Body Doc Link PMC2949876 Disease Relevance 0 Pain Relevance 0
MC3R protein expression in the brain of insular lizards was about three times higher than in mainland lizards' brains (range: 1.5-5.3, n = 5; t-test: t = 4.506, p = 0.001).
Gene_expression (expression) of MC3R in brains
6) Confidence 0.17 Published 2010 Journal BMC Evol Biol Section Body Doc Link PMC2949876 Disease Relevance 0 Pain Relevance 0
Western blot analyses showed significant differences in the expression of MC3R and MC4R in the lizards' brain and testes, using actin as an internal standard (Figures 3b and 3c).
Gene_expression (expression) of MC3R in brain
7) Confidence 0.06 Published 2010 Journal BMC Evol Biol Section Body Doc Link PMC2949876 Disease Relevance 0 Pain Relevance 0
We tested differential expression of MC3R and MC4R between island and mainland populations by western blotting of testis and brain lysates (n = 10 males per population) and used lysates from human neuroblastoma cells (SH-SY5Y) as a control.
Gene_expression (expression) of MC3R in testis associated with neuroblastoma
8) Confidence 0.06 Published 2010 Journal BMC Evol Biol Section Body Doc Link PMC2949876 Disease Relevance 0.09 Pain Relevance 0

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