INT75054

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Context Info
Confidence 0.09
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.63
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC2R) signal transducer activity (MC2R)
Anatomy Link Frequency
B16-F1 1
MC3 1
MC2R (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 2 95.92 Very High Very High Very High
Enkephalin 3 80.04 Quite High
melanocortin 1 receptor 3 75.00 Quite High
Somatostatin 1 70.24 Quite High
Inflammation 2 68.96 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 4 99.30 Very High Very High Very High
Experimental Melanoma 2 95.60 Very High Very High Very High
INFLAMMATION 4 78.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results provide important pharmacological characterization of common MC1 receptor variants in various world populations.
MC1 receptor Binding (characterization) of
1) Confidence 0.09 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15482480 Disease Relevance 0.11 Pain Relevance 0.12
We also tested these analogues on B16-F1 mouse melanoma cells endogenously expressing the MC1 receptor for binding and for ability to increase cAMP levels as well as on COS-7 cells transfected with the human MC receptors.
MC1 receptor Binding (binding) of in B16-F1 associated with skin cancer
2) Confidence 0.04 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 17040213 Disease Relevance 0.18 Pain Relevance 0.10
The data indicate that HS401 (Ac-Tyr-Lys-Pro-Val-NH2) and HS402 (Ac-Lys-Pro-Val-Tyr-NH2) selectively bound to the MC1 receptor and stimulated cAMP generation in a concentration dependent way while the other Tyr- and Trp-containing alpha-MSH11-13 analogues neither bound to MC receptors nor stimulated cAMP.
MC1 receptor Binding (bound) of
3) Confidence 0.03 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 17040213 Disease Relevance 0.16 Pain Relevance 0.11
For the other receptors, it has slightly higher affinity for the MC5 receptor than for the MC3 and MC4 receptors. 153N-6 was found to be selective for the MC1 receptor.
MC5 receptor Binding (affinity) of in MC3
4) Confidence 0.01 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574823 Disease Relevance 0.18 Pain Relevance 0.30

General Comments

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