INT75057

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Context Info
Confidence 0.39
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Msx1) small molecule metabolic process (POMC) DNA binding (Msx1)
cell-cell signaling (POMC) cytoplasm (POMC) extracellular space (POMC)
POMC (Homo sapiens)
Msx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 94.48 High High
Enkephalin 3 94.40 High High
melanocortin 1 receptor 2 61.76 Quite High
Somatostatin 1 44.24 Quite Low
cytokine 1 11.68 Low Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Melanoma 2 99.56 Very High Very High Very High
Skin Cancer 140 82.04 Quite High
Disease 8 74.28 Quite High
Melanoma 27 72.12 Quite High
Adhesions 3 59.88 Quite High
Metastasis 14 55.00 Quite High
Sunburn 3 50.00 Quite Low
Breast Cancer 2 33.76 Quite Low
Cancer 40 8.48 Low Low
Necrosis 1 8.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSH and ACTH bind to receptors that couple to heterotrimeric guanine nucleotide-binding proteins(G proteins) which activate adenylyl cyclise [Figure 1].[117] Using PCR with primers based on conserved areas of other members of 7-transmembrane G protein-linked receptors, Gantz et al.,[118] isolated several genes encoding an ‘orphan’ subfamily of receptors specific for melanocortins.
ACTH Binding (bind) of MSH
1) Confidence 0.39 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 0.42 Pain Relevance 0.06
Moreover, we tested the binding and cAMP response of MSH-B in comparison with alpha-MSH on murine B16 melanoma cells.
alpha-MSH Binding (binding) of MSH-B associated with experimental melanoma
2) Confidence 0.01 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574823 Disease Relevance 0.19 Pain Relevance 0.14

General Comments

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