INT75063

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 2.82
Pain Relevance 7.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
NAc 2
projection neurons 2
brain 2
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 403 100.00 Very High Very High Very High
Nucleus accumbens 61 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
Morphine 16 100.00 Very High Very High Very High
opioid receptor 3 99.52 Very High Very High Very High
addiction 193 99.16 Very High Very High Very High
alcohol 153 99.00 Very High Very High Very High
opiate 5 98.64 Very High Very High Very High
projection neuron 10 98.36 Very High Very High Very High
drug abuse 3 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 11 99.68 Very High Very High Very High
Alcohol Addiction 225 99.16 Very High Very High Very High
Opiate Addiction 2 98.64 Very High Very High Very High
Drug Dependence 8 97.24 Very High Very High Very High
Depression 8 91.52 High High
Targeted Disruption 47 87.60 High High
Brain Disease 3 79.24 Quite High
Attention Deficit Hyperactivity Disorder 163 73.96 Quite High
Ataxia 1 26.68 Quite Low
Substance Withdrawal Syndrome 3 21.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, deregulated expression of D2R isoforms might be involved in the vulnerability of an individual to drug abuse.
Regulation (deregulated) of Gene_expression (expression) of D2R associated with drug abuse
1) Confidence 0.62 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943831 Disease Relevance 0.10 Pain Relevance 0.80
Effects of single and repeated morphine administration on the prodynorphin, proenkephalin and dopamine D2 receptor gene expression in the mouse brain.
Regulation (Effects) of Gene_expression (expression) of dopamine D2 receptor in brain associated with dopamine, enkephalin and morphine
2) Confidence 0.51 Published 1997 Journal Neuropeptides Section Title Doc Link 9574833 Disease Relevance 0 Pain Relevance 1.00
In this article we investigated the contribution of the DA D2 receptor (D2R) in the control of this response.
Regulation (control) of Spec (investigated) Gene_expression (contribution) of D2R associated with dopamine
3) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943831 Disease Relevance 0 Pain Relevance 0.63
The hypothesis of a segregated expression of D1R and D2R in the distinct populations of striatal projection neurons was initially suggested by indirect evidence (Beckstead, 1988) and subsequently shown by retrograde tracing (Gerfen et al., 1990).
Regulation (segregated) of Gene_expression (expression) of D2R in projection neurons associated with projection neuron
4) Confidence 0.45 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.50
Further studies are clearly warranted to determine how the specificity of D1R and D2R expression, as well as that of other genes, is controlled in the two populations of striatal MSNs during development.
Spec (determine) Regulation (specificity) of Gene_expression (expression) of D2R
5) Confidence 0.45 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.12
It was suggested that the developmental regulation of D1R and D2R mRNAs would result from intrinsic genetic programs, while the dopaminergic innervation would control the D1R and D2R protein synthesis (Jung and Bennett, 1996).
Regulation (control) of Gene_expression (synthesis) of D2R protein
6) Confidence 0.45 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.12
Combined, our data argue that control of NAc D2r expression is critical for Rxrgamma-mediated modulation of affective behaviors.
Regulation (control) of Gene_expression (expression) of D2r in NAc associated with nucleus accumbens
7) Confidence 0.44 Published 2010 Journal Neuron Section Abstract Doc Link 20620876 Disease Relevance 0.31 Pain Relevance 0.50
In this article we investigated the contribution of the DA D2 receptor (D2R) in the control of this response.
Regulation (control) of Spec (investigated) Gene_expression (contribution) of D2 receptor associated with dopamine
8) Confidence 0.39 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943831 Disease Relevance 0 Pain Relevance 0.63
In contrast striatal mRNA expression levels for DRD2 and PPE did not differ between control and mutant animals (Fig. 5A and B).
Neg (not) Regulation (differ) of Gene_expression (expression) of DRD2
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.62
On the basis of numerous studies that have described interactions between the dopaminergic and opioidergic systems, we have investigated whether genetic deletion of dopamine D2 receptors (D2R) might influence the expression of central opioid receptors.
Spec (might) Regulation (influence) of Gene_expression (expression) of D2R associated with dopamine and opioid receptor
10) Confidence 0.26 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424009 Disease Relevance 0.09 Pain Relevance 0.41
Striatal DRD1 and DRD2 expression is unaltered in the coloboma mouse [157].
Regulation (unaltered) of Gene_expression (expression) of DRD2 associated with ocular toxicity (including many sub-types)
11) Confidence 0.14 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.97 Pain Relevance 0.50
Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution.
Regulation (altering) of Gene_expression (expression) of dopamine D2 receptor associated with addiction, dopamine, methadone and opiate
12) Confidence 0.05 Published 2009 Journal Pharmacogenet. Genomics Section Title Doc Link 19373123 Disease Relevance 0.10 Pain Relevance 0.54
This promoter polymorphism plays an important role in D2 receptor expression.
Regulation (role) of Gene_expression (expression) of D2 receptor
13) Confidence 0.04 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.49 Pain Relevance 0.38
Pohjalainen et al. [21] reported an association between A1 allele and low D2 receptor availability in healthy subjects indicating that A1 allele of the TaqI A polymorphism might be in linkage disequilibrium with a mutation in the promoter/regulatory gene that affects dopamine D2 receptor expression.
Regulation (affects) of Gene_expression (expression) of D2 receptor associated with dopamine
14) Confidence 0.03 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.29 Pain Relevance 0.30
Considering this background, the association of TaqI A1 allele with AD in the present study could be due to the altered D2 receptor expression and reward mechanism in alcohol dependent subjects.
Regulation (altered) of Gene_expression (expression) of D2 receptor associated with addiction and alcohol
15) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.48 Pain Relevance 0.30

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