INT75069

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Context Info
Confidence 0.09
First Reported 1997
Last Reported 1997
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk) molecular_function (Pkhd1l1) cellular_component (Pkhd1l1)
biological_process (Pkhd1l1)
Anatomy Link Frequency
nucleus accumbens 3
striatum 1
Penk (Mus musculus)
Pkhd1l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 14 99.24 Very High Very High Very High
Morphine 14 97.36 Very High Very High Very High
Dopamine 4 75.00 Quite High
Enkephalin 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The above results indicate that repeated morphine leads to long-lasting upregulation of the PDYN gene expression in the mouse nucleus accumbens and striatum; on the other hand, the PENK and D2 mRNA gene expressions are either inhibited or remain unchanged, significant changes being observed in the nucleus accumbens only.
PENK Neg (unchanged) Regulation (unchanged) of Gene_expression (expressions) of D2 mRNA in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.09 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.92
The above results indicate that repeated morphine leads to long-lasting upregulation of the PDYN gene expression in the mouse nucleus accumbens and striatum; on the other hand, the PENK and D2 mRNA gene expressions are either inhibited or remain unchanged, significant changes being observed in the nucleus accumbens only.
PENK Neg (unchanged) Regulation (unchanged) of in striatum Gene_expression (expressions) of D2 mRNA in nucleus accumbens associated with nucleus accumbens and morphine
2) Confidence 0.03 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.92

General Comments

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