INT75105

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 3.33
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SLC15A4)
Anatomy Link Frequency
plasma 4
macrophages 2
fibroblast 1
SLC15A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 99.78 Very High Very High Very High
cytokine 198 90.96 High High
Inflammation 77 90.00 High High
agonist 11 76.40 Quite High
sodium channel 55 75.44 Quite High
Inflammatory response 11 65.92 Quite High
metalloproteinase 33 50.00 Quite Low
Calcium channel 13 50.00 Quite Low
carbamazepine 2 50.00 Quite Low
Gabapentin 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 18 100.00 Very High Very High Very High
Gingival Overgrowth 110 99.64 Very High Very High Very High
Pathologic Processes 22 98.36 Very High Very High Very High
Convulsion 22 95.88 Very High Very High Very High
Wound Healing 22 93.00 High High
INFLAMMATION 88 90.00 High High
Thrombosis 2 84.00 Quite High
Hemorrhage 12 78.16 Quite High
Fibrosis 14 76.80 Quite High
Cardiovascular Disease 1 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to CBZ, PHT produced a small hyperpolarizing shift in the voltage dependence of steady-state inactivation.
Gene_expression (produced) of PHT
1) Confidence 0.19 Published 1998 Journal Epilepsia Section Body Doc Link 9578025 Disease Relevance 0.07 Pain Relevance 0
Thus, surgical shunt therapy, particularly DSRS, is a popular palliative method to decompress PHT.
Gene_expression (decompress) of PHT associated with pressure and volume under development and palliative
2) Confidence 0.08 Published 2007 Journal BMC Surg Section Body Doc Link PMC1905910 Disease Relevance 1.11 Pain Relevance 0.10
but not IL-6 by PHT.
Gene_expression (by) of PHT
3) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0.03
How PHT and HPPH impact monocyte/macrophage-fibroblast interactions and MMP production requires further study.
Gene_expression (production) of PHT in fibroblast
4) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.18 Pain Relevance 0.11
g/mL PHT significantly blunted LPS-induced levels of MMP-1 (p < 0.05).
Gene_expression (blunted) of PHT
5) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0
Previous studies have determined that PHT plasma levels of 10-20 ?
Spec (determined) Gene_expression (levels) of PHT in plasma
6) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.09 Pain Relevance 0
Previous studies have determined that PHT plasma levels of 10-20 ?
Spec (determined) Gene_expression (plasma) of PHT in plasma
7) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.09 Pain Relevance 0
Although PHT was detected in all of the GCF and plasma samples, the mean concentration of PHT was significantly greater in GCF compared to plasma (294.99 ± 430.15 ?
Gene_expression (detected) of PHT in plasma
8) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.46 Pain Relevance 0.21
g/mL PHT-Na+ (high dose), 3) 15 ?
Gene_expression (/) of PHT
9) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0
Thus, the concentrations used in our study represent therapeutic as well as elevated levels of PHT permitting the evaluation of dose on MMP and TIMP production.
Gene_expression (levels) of PHT
10) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.10 Pain Relevance 0
We have demonstrated that the clinical presentation of PHT-induced gingival overgrowth is associated with a specific macrophage phenotype characterized by high expression levels of IL-1?
Gene_expression (presentation) of PHT in macrophage associated with gingival overgrowth
11) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.66 Pain Relevance 0.13
Further, the concentration of plasma PHT was significantly higher in responders compared to non-responders (16.09 ± 4.21 ?
Gene_expression (concentration) of PHT in plasma
12) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.41 Pain Relevance 0.16
In this study, elevated levels of PHT in LPS-stimulated macrophages were associated with decreases in both MMP and TIMP levels.
Gene_expression (levels) of PHT in macrophages
13) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.08 Pain Relevance 0

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