INT75111

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Context Info
Confidence 0.40
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.44
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
hypothalamus 2
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 2 64.44 Quite High
nMDA receptor 4 60.48 Quite High
medulla 8 49.44 Quite Low
Locus ceruleus 32 7.44 Low Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 172 99.16 Very High Very High Very High
Growth Problems 8 96.96 Very High Very High Very High
Sleep Disorders 276 92.68 High High
Death 40 92.56 High High
Congenital Anomalies 4 86.32 High High
Hyperglycemia 4 82.80 Quite High
Thalassemia 5 75.00 Quite High
Injury 4 61.12 Quite High
Apoptosis 16 49.80 Quite Low
Sprains And Strains 20 37.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the IGF-I generation test, after GH injection, the thalassaemic children had significantly lower IGF-I and IGFBP-3 levels 86.7 +/- 11.2 ng/ml and 2.05 +/- 0.51 mg/l respectively) than those in the CSS group (226 +/- 45.4 ng/ml and 2.8 +/- 0.43 mg/l respectively).
Negative_regulation (lower) of Positive_regulation (levels) of IGFBP-3 associated with growth problems
1) Confidence 0.40 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.60 Pain Relevance 0.06
We found that increased IGFBP3 decreases both hypocretin mRNA, and hypocretin peptide content in hypothalamus and target areas (Fig. 3A–C).
Negative_regulation (decreases) of Positive_regulation (increased) of IGFBP3 in hypothalamus
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.93 Pain Relevance 0.03
We hypothesize that increased IGFBP3 amount in HCRT cells decreases HCRT production and reduces wake under physiological conditions.
Negative_regulation (decreases) of Positive_regulation (increased) of IGFBP3
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.44 Pain Relevance 0
IGFBP3 overexpression increases sleep at the end of the active period
Negative_regulation (sleep) of Positive_regulation (increases) of IGFBP3
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.01 Pain Relevance 0
We hypothesize that increased IGFBP3 amount in HCRT cells decreases HCRT production and reduces wake under physiological conditions.
Negative_regulation (reduces) of Positive_regulation (increased) of IGFBP3
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.45 Pain Relevance 0

General Comments

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