INT75114

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Context Info
Confidence 0.52
First Reported 1998
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.42
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ntsr1) signal transducer activity (Ntsr1)
Anatomy Link Frequency
RVM 2
cerebral cortex 1
Ntsr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 12 98.56 Very High Very High Very High
cerebral cortex 2 98.12 Very High Very High Very High
antinociception 10 98.04 Very High Very High Very High
gABA 8 98.04 Very High Very High Very High
Serotonin 7 96.64 Very High Very High Very High
spinal dorsal horn 40 95.96 Very High Very High Very High
antagonist 4 95.60 Very High Very High Very High
intrathecal 13 92.84 High High
agonist 2 90.56 High High
Inflammation 36 87.56 High High
Disease Link Frequency Relevance Heat
Nociception 22 100.00 Very High Very High Very High
Disease 18 99.54 Very High Very High Very High
Generalized Anxiety Disorder 2 98.50 Very High Very High Very High
INFLAMMATION 36 87.56 High High
Pain 11 86.96 High High
Urological Neuroanatomy 4 63.80 Quite High
Hypoalagesia 3 51.72 Quite High
Injury 12 41.84 Quite Low
Toxicity 7 38.72 Quite Low
Camurati-engelmann Disease 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we used immunohistochemical techniques to show that the NTR1, but not the NTR2 is expressed by spinally projecting serotonergic neurons of the RVM.
Neg (not) Gene_expression (expressed) of NTR1 in RVM associated with rostral ventromedial medulla
1) Confidence 0.52 Published 2005 Journal Pain Section Abstract Doc Link 15733655 Disease Relevance 0 Pain Relevance 0.88
The results of these experiments provide anatomical and behavioral evidence that activation of NTR1-expressing spinally projecting neurons in the RVM produces antinociception through release of serotonin in the spinal dorsal horn.
Gene_expression (expressing) of NTR1-expressing in RVM associated with antinociception, spinal dorsal horn, serotonin and rostral ventromedial medulla
2) Confidence 0.45 Published 2005 Journal Pain Section Abstract Doc Link 15733655 Disease Relevance 0 Pain Relevance 1.01
In cerebral cortex, the developmental increase in NTRL expression was correlated over time with the decrease in NTRH expression previously documented in the rat, suggesting a progressive takeover of the latter by the former for transduction of the effects of NT in this structure.
Gene_expression (expression) of NTRH in cerebral cortex associated with cerebral cortex
3) Confidence 0.31 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9579398 Disease Relevance 0.06 Pain Relevance 0.25
Three of these genes code for anti-nociceptive products involved in GABA neurotransmission: GAD 67, and GABAB1b and GABAB1f receptors [12-14], while the other four genes generate potentially pro-nociceptive products, preprocholecystokinin, and NtsR1 neurotensin, H1 histamine and 5-HT1b serotonergic receptors [26,31-34].
Gene_expression (generate) of NtsR1 neurotensin associated with nociception, gaba and generalized anxiety disorder
4) Confidence 0.03 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 1.25 Pain Relevance 0.69
In subsequent work, the delivery vector was improved by incorporation of the fusogenic peptide hemagglutinin HA2 and the Vp1 nuclear localization signal; these targeted gene carriers could be applied toward the treatment of Parkinson’s disease, as the high-affinity neurotensin receptor is expressed predominantly in the nigrostriatal and mesolimbic dopaminergic systems (62).


Gene_expression (expressed) of neurotensin receptor associated with disease
5) Confidence 0.03 Published 2007 Journal Pharm Res Section Body Doc Link PMC2292496 Disease Relevance 0.10 Pain Relevance 0.14

General Comments

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