INT75117

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.05
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ntsr2) signal transducer activity (Ntsr2)
Anatomy Link Frequency
medulla 2
anterior olfactory nucleus 1
gigantocellular reticular nucleus 1
medial 1
cerebral cortex 1
Ntsr2 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 6 99.36 Very High Very High Very High
cerebral cortex 5 99.36 Very High Very High Very High
Central grey 6 98.24 Very High Very High Very High
Rostral ventromedial medulla 6 97.92 Very High Very High Very High
analgesia 6 97.72 Very High Very High Very High
Antinociceptive 6 97.52 Very High Very High Very High
antinociception 5 95.60 Very High Very High Very High
Raphe magnus 5 94.84 High High
agonist 1 90.56 High High
tail-flick 2 84.24 Quite High
Disease Link Frequency Relevance Heat
Nociception 6 99.76 Very High Very High Very High
Urological Neuroanatomy 7 98.24 Very High Very High Very High
Hypothermia 1 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally a high expression of NTRL was evident in brainstem structures implicated in descending antinociceptive influences (e.g., the periaqueductal gray, nucleus raphe magnus, gigantocellular reticular nucleus, pars alpha, and lateral paragigantocellular nucleus) consistent with the proposed mediation of NT-induced analgesia by the NTRL.
Gene_expression (expression) of NTRL in gigantocellular reticular nucleus associated with raphe magnus, medulla, central grey, antinociceptive and analgesia
1) Confidence 0.78 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9579398 Disease Relevance 0.10 Pain Relevance 0.28
Although most of the regions found here to express NTRL mRNA were previously reported to be devoid of mRNA encoding the high affinity NT receptor (NTRH), a few areas (e.g., the anterior olfactory nucleus, medial septum, diagonal band of Broca, reticular thalamic nucleus, suprachiasmatic hypothalamic nucleus, and pontine nucleus) were enriched in both receptor subtypes, suggesting a possible coexpression of these receptors by the same cells.
Gene_expression (express) of NTRL in anterior olfactory nucleus
2) Confidence 0.68 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9579398 Disease Relevance 0.09 Pain Relevance 0.30
Ontogenic studies revealed that in the mouse brain, NTRL mRNA was detected only from postnatal day 14 and did not reach adulthood concentrations before day 30.
Gene_expression (detected) of NTRL in brain
3) Confidence 0.68 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9579398 Disease Relevance 0.07 Pain Relevance 0.27
The expression of Ntsr2 mRNA was greater than that of Ntsr1 in the periaqueductal gray (PAG) and the rostral ventral medulla (RVM).
Gene_expression (expression) of Ntsr2 in medulla associated with medulla, urological neuroanatomy and central grey
4) Confidence 0.64 Published 2004 Journal Brain Res. Section Abstract Doc Link 14725975 Disease Relevance 0.63 Pain Relevance 0.26
In cerebral cortex, the developmental increase in NTRL expression was correlated over time with the decrease in NTRH expression previously documented in the rat, suggesting a progressive takeover of the latter by the former for transduction of the effects of NT in this structure.
Gene_expression (expression) of NTRL in cerebral cortex associated with cerebral cortex
5) Confidence 0.53 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9579398 Disease Relevance 0.07 Pain Relevance 0.25
Although most of the regions found here to express NTRL mRNA were previously reported to be devoid of mRNA encoding the high affinity NT receptor (NTRH), a few areas (e.g., the anterior olfactory nucleus, medial septum, diagonal band of Broca, reticular thalamic nucleus, suprachiasmatic hypothalamic nucleus, and pontine nucleus) were enriched in both receptor subtypes, suggesting a possible coexpression of these receptors by the same cells.
Gene_expression (express) of NTRL in medial
6) Confidence 0.23 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9579398 Disease Relevance 0.09 Pain Relevance 0.30
In the present study, we used immunohistochemical techniques to show that the NTR1, but not the NTR2 is expressed by spinally projecting serotonergic neurons of the RVM.
Neg (not) Gene_expression (expressed) of NTR2 in RVM associated with rostral ventromedial medulla
7) Confidence 0.13 Published 2005 Journal Pain Section Abstract Doc Link 15733655 Disease Relevance 0 Pain Relevance 0.88

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