INT75136

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 8.81
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
plasma 2
myotube 1
heart 1
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 163 100.00 Very High Very High Very High
Inflammatory stimuli 6 99.96 Very High Very High Very High
opioid receptor 168 99.32 Very High Very High Very High
Lasting pain 9 99.28 Very High Very High Very High
gABA 3 98.80 Very High Very High Very High
Neurotransmitter 9 98.56 Very High Very High Very High
Kinase C 205 97.92 Very High Very High Very High
nMDA receptor 7 95.52 Very High Very High Very High
Glutamate 24 87.72 High High
spinal dorsal horn 1 84.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 115 99.78 Very High Very High Very High
Adenocarcinoma 66 99.78 Very High Very High Very High
Pain 36 99.28 Very High Very High Very High
Apoptosis 239 98.44 Very High Very High Very High
Parkinson's Disease 366 97.44 Very High Very High Very High
Lung Injury 40 97.04 Very High Very High Very High
Cancer 264 95.68 Very High Very High Very High
Toxicity 59 95.40 Very High Very High Very High
Cv Unclassified Under Development 222 94.28 High High
Stress 148 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of inactive Akt and nNOS to the MOR also involves the HINT1 protein.
Akt Binding (binding) of associated with opioid receptor
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.17 Pain Relevance 1.10
The precise protein interactions between HINT1 and Akt or nNOS are presently being explored.
Akt Binding (interactions) of
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.16 Pain Relevance 1.00
PI(3,4,5)P3 activates mTORC1 through the recruitment and activation of PKB [19].
PKB Binding (recruitment) of
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.21 Pain Relevance 0
While PD restores myotube size and MyHC content by blocking ERK without affecting Akt activity, the opposite occurs in follistatin-hyperexpressing cultures, wherein ERK activation remains comparable to non-transfected TNF?
Akt Binding (activity) of in myotube
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.18 Pain Relevance 0
Nilotinib showed no activity against a wide panel of other protein kinases at concentrations below 3 ?
kinases Binding (concentrations) of
5) Confidence 0.18 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0 Pain Relevance 0.04
Additionally, the loss of PTEN was found only in a subset of PDAC specimens characterized by enhanced PKB?
PKB Binding (characterized) of associated with adenocarcinoma
6) Confidence 0.13 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.76 Pain Relevance 0.05
The isoprenoid geranylgeranylpyrophosphate activates a group of Rho, Rac and cdc42 proteins (Adamson et al. 1992).
Rac Binding (group) of
7) Confidence 0.13 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.32 Pain Relevance 0
Rac is then able to translocate to the plasma membrane, where its prenyl group inserts into the membrane, tethering Rac to its inner face and facilitating Rac's interaction with p67phox [45].
Rac Binding (interaction) of in plasma
8) Confidence 0.13 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.05
During activation by an inflammatory stimulus, Rac binds GTP and dissociates from RhoGDI.
Rac Binding (binds) of associated with inflammatory stimuli
9) Confidence 0.12 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.10 Pain Relevance 0.08
Although these data do not support a role for protein kinases within the mitochondrial matrix in the inhibition of the MPTP following preconditioning, they do not exclude the possibility of regulation by phosphorylation of proteins exposed to cytosolic kinases, such as those in the outer mitochondrial membrane or bound to it using scaffolding proteins [142,143].
kinases Binding (bound) of associated with parkinson's disease
10) Confidence 0.12 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.19 Pain Relevance 0
Here too we were unable to detect consistent migration of protein kinases to the mitochondria or changes in phosphorylation of a mitochondrial protein, arguing against this protection being mediated by phosphorylation (see Section 7.1).
kinases Neg (unable) Binding (migration) of
11) Confidence 0.12 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.82 Pain Relevance 0
Nor have we been able to observe any consistent migration of protein kinases to the mitochondria or changes in phosphorylation of a mitochondrial protein (see Sections 6 and 7.1).
kinases Binding (migration) of
12) Confidence 0.12 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.61 Pain Relevance 0
In this study, overexpression of ALDH2 was associated with a suppression of phosphatase activity which leads to enhanced Akt and AMP-activated protein kinase activities and regulation of their downstream targets Foxo3 transcription factor and caspase-3.87,88 Thus, ALDH2 appears critical in protecting the heart from aldehyde toxicity and is able to elicit signalling events that can protect against myocardial damages caused by acute ethanol toxicity.
Akt Binding (targets) of in heart associated with toxicity
13) Confidence 0.11 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.67 Pain Relevance 0.06
Two specific sites of phosphorylation [targeted by Akt (Ser28) and cyclinD3/cdk (Ser302)] were identified within CUGBP1 molecule [78].
Akt Binding ([targeted) of
14) Confidence 0.09 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.47 Pain Relevance 0
Caveolin-1, a 22 kDa protein, participates in caveolae formation and binds and inactivates cell surface protein kinases through its caveolar scaffolding domain (residues 82 to 101) [8].
kinases Binding (binds) of
15) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.99 Pain Relevance 0
Polyclonal antibodies directed to pan-Akt, phospho-Akt (Thr308), PLC-?
Akt Binding (directed) of
16) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0.10
Polyclonal antibodies directed to pan-Akt, phospho-Akt (Thr308), PLC-?
Akt Binding (directed) of
17) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0.10
Activated PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the plasma membrane, which increases the membrane recruitment of Akt/PKB and its activator PDK1, leading to the activation of Akt.
Akt Binding (recruitment) of in plasma
18) Confidence 0.07 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.16 Pain Relevance 0
Non radioactive assay for Akt used similar protocol with only the radioactive ATP being replaced by 200mM of cold ATP and Gsk3?
Akt Binding (assay) of
19) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Taken together, these results strongly suggest Rac-Rho crosstalk as the mechanism underlying protective effects of OxPAPC in the model of VILI.
Rac Binding (crosstalk) of associated with lung injury
20) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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