INT75137

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2011
Negated 10
Speculated 4
Reported most in Body
Documents 74
Total Number 78
Disease Relevance 37.89
Pain Relevance 9.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
cerebellar granule cells 1
nucleus 1
motor neurons 1
kidney 1
dopamine neurons 1
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 203 100.00 Very High Very High Very High
chemokine 41 100.00 Very High Very High Very High
Kinase C 140 99.90 Very High Very High Very High
antidepressant 6 99.52 Very High Very High Very High
Delta opioid receptors 9 99.24 Very High Very High Very High
Dopamine 348 99.18 Very High Very High Very High
opioid receptor 168 98.48 Very High Very High Very High
Glutamate receptor 5 98.20 Very High Very High Very High
Calcium channel 9 97.84 Very High Very High Very High
dexamethasone 18 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 150 99.92 Very High Very High Very High
Targeted Disruption 320 99.36 Very High Very High Very High
Apoptosis 305 99.36 Very High Very High Very High
Aging 268 99.32 Very High Very High Very High
Cancer 704 98.92 Very High Very High Very High
Disease 278 98.88 Very High Very High Very High
Obesity 479 98.72 Very High Very High Very High
Chronic Myeloid Leukemia 62 98.44 Very High Very High Very High
Myeloid Leukemia 130 98.28 Very High Very High Very High
Autoimmune Disease 38 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggest PTEN function in dopamine neurons is not limited to the classical deregulation of the Akt pathway, and PTEN may also have an effect on distinct functions related to dopamine-mediated cognition.
Regulation (deregulation) of Akt in dopamine neurons associated with cognitive disorder and dopamine
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.31 Pain Relevance 0.62
The changes in ERK and Akt phosphorylation levels were also observed in white adipose tissues of UCP1-knockout mice fed the evodiamine diet.
Regulation (changes) of Akt in adipose tissues associated with targeted disruption
2) Confidence 0.47 Published 2008 Journal Endocrinology Section Abstract Doc Link 17884939 Disease Relevance 0.38 Pain Relevance 0.13
After preincubation with an Akt inhibitor, these relaxations were not significantly different among the three Akt inhibitor-treated groups (controls, diabetics, and simvastatin-treated diabetics).
Regulation (controls) of Akt associated with diabetes mellitus
3) Confidence 0.45 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 1.00 Pain Relevance 0.33
After preincubation with an Akt inhibitor, these relaxations were not significantly different among the three Akt inhibitor-treated groups (controls, diabetics, and simvastatin-treated diabetics).
Neg (not) Regulation (different) of Akt associated with diabetes mellitus
4) Confidence 0.45 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 1.00 Pain Relevance 0.33
In a separate experiment, we examined the effect of Akt inhibition by triciribine on cell viability following dexamethasone treatment.
Spec (examined) Regulation (effect) of Akt associated with dexamethasone
5) Confidence 0.45 Published 2010 Journal Neuroscience Section Abstract Doc Link 20038443 Disease Relevance 0.63 Pain Relevance 0.66
In a separate experiment, we determined the effect of Akt inhibition on cell viability in the presence of LA and bupivacaine.
Spec (determined) Regulation (effect) of Akt
6) Confidence 0.44 Published 2010 Journal Neurotoxicology Section Body Doc Link 19879292 Disease Relevance 0.16 Pain Relevance 0
The down-regulation of Akt gene in microarray results points to lack of maturation of cell migrating to matrigel, since in Akt-defficient mice the enhance of angiogenic response with impairment of blood vessels maturation has been found by others [31].
Regulation (regulation) of Akt gene in blood vessels
7) Confidence 0.33 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.97 Pain Relevance 0
However, the phosphorylation level of Akt, a key signal molecule mediating the metabolic actions of insulin, was not altered by reduction of ROS.
Neg (not) Regulation (altered) of Akt
8) Confidence 0.31 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.29 Pain Relevance 0.08
Furthermore, analysis of insulin signaling in the Alb Cre + mice revealed no differences in the activation status of the insulin-regulated proteins PKB, GSK-3 and GS.
Regulation (regulated) of PKB
9) Confidence 0.30 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.40 Pain Relevance 0
In 9 tumor samples that passed quality control assessments for ECL there was no post treatment up-regulation of relative p/tAKT (S473) after 8 days of exposure to rapamycin (p?
Regulation (regulation) of AKT associated with cancer
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882366 Disease Relevance 0.56 Pain Relevance 0
No effect of selective inhibitors of p38-MAPK, phosphatidylinositol 3-kinase (PI3-K)/Akt, and glycogen synthase kinase (GSK-3) on the imipramine-induced inhibition of GR function was detected.
Neg (No) Regulation (effect) of Akt
11) Confidence 0.25 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.07 Pain Relevance 0.34
Predicted molecular involvement in this network were the Akt protein family (protein kinase B), the NF?
Regulation (involvement) of protein kinase B
12) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.15 Pain Relevance 0.16
The effects of lithium on phosphorylated Akt and GSK3?
Regulation (effects) of Akt
13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.90 Pain Relevance 0.08
Most significantly, and consistent with lack of Erk1/2 phosphorylation, we found a profound down-regulation of all three classes of serine/threonine kinases that monitor various aspects of mitosis, including Cdk1, Plk1 and two members of Aurora family kinase, Aurora A and B (Figure 4).
Regulation (regulation) of kinases
14) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
Indomethacin treatment in present experiments down-regulated Raf and Akt genes, which would reduce tumor cell proliferation.
Regulation (regulated) of Akt associated with cancer
15) Confidence 0.22 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675840 Disease Relevance 0.64 Pain Relevance 0
Cholesterol by modulating caveolae formation regulates several signaling molecules like AKT, IGFR, EGFR and Rho which are involved in cell growth and survival.
Regulation (regulates) of AKT
16) Confidence 0.21 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2745153 Disease Relevance 0.91 Pain Relevance 0
Indeed, reduced levels in the phosphorylated form, but no changes in total AKT were found, after exposure to the drug.
Neg (no) Regulation (changes) of AKT
17) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.44 Pain Relevance 0
Mammalian Tor (mTOR) pathway was activated, confirmed by Frap1, Rheb and Akt1 up-regulation.
Regulation (regulation) of Akt1
18) Confidence 0.20 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.22 Pain Relevance 0
This regulation integrates the positive effects of PI3K, Akt, nNOS, PKC, Src, NMDAR and CaMKII on MOR inhibition.
Regulation (effects) of Akt associated with kinase c and opioid receptor
19) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.07 Pain Relevance 0.96
To analyze the effect of morphine on Akt activity, an acute 10 nmol dose was injected icv into mice.
Spec (analyze) Regulation (effect) of Akt associated with morphine
20) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.08 Pain Relevance 0.49

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