INT75158

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Context Info
Confidence 0.28
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.12
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Fgf5) extracellular region (Fgf5)
Fgf5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 106 99.96 Very High Very High Very High
mu opioid receptor 2 99.00 Very High Very High Very High
agonist 16 98.08 Very High Very High Very High
antinociception 14 89.28 High High
Morphine 10 87.84 High High
Buprenorphine 8 87.28 High High
methadone 8 86.68 High High
Opioid 6 85.96 High High
Analgesic 8 81.28 Quite High
Antinociceptive 8 79.52 Quite High
Disease Link Frequency Relevance Heat
Cancer 10 99.92 Very High Very High Very High
Necrosis 10 99.68 Very High Very High Very High
Skin Diseases 4 93.56 High High
Systemic Sclerosis 68 91.20 High High
Targeted Disruption 10 77.44 Quite High
Limited Scleroderma 2 74.60 Quite High
Diffuse Scleroderma 2 72.48 Quite High
Hypersensitivity 2 62.00 Quite High
Autoimmune Disease 66 50.00 Quite Low
Adhesions 4 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, only one cytokine, FGF5, was highly expressed in this group.
Gene_expression (expressed) of FGF5 associated with cytokine
1) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.95 Pain Relevance 0.05
These highly expressed genes included cell cycle genes CENPE, CDC7 and CDT1, FGF5, tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) and TRAF interacting protein (TRIP).
Gene_expression (expressed) of FGF5 associated with necrosis and cancer
2) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.01 Pain Relevance 0.10
The expression of alpha-subunits of Gi-protein classes, Gi1, Gi2, Gi3, Go1, Go2 and Gz, and those of the Gq-protein family, Gq and G11, was reduced by administration of antisense oligodeoxynucleotides (ODNs) complementary to sequences in their respective mRNAs.
Gene_expression (expression) of Go1
3) Confidence 0.06 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275413 Disease Relevance 0.08 Pain Relevance 1.30
The expression of alpha-subunits of Gi-protein classes, Gi1, Gi2, Gi3, Go1, Go2 and Gz, and those of the Gq-protein family, Gq and G11, was reduced by administration of antisense oligodeoxynucleotides (ODNs) complementary to sequences in their respective mRNAs.
Gene_expression (expression) of Go2
4) Confidence 0.06 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275413 Disease Relevance 0.08 Pain Relevance 1.31
To analyze the selectivity of delta receptor subtypes to regulate different classes of G proteins, the expression of the alpha-subunits of Gi2, Gi3, Go1, Go2, Gq and G11 transducer proteins was reduced by administration of oligodeoxynucleotides (ODNs) complementary to sequences in their respective mRNAs.
Gene_expression (expression) of Go1
5) Confidence 0.02 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580632 Disease Relevance 0 Pain Relevance 0.41
To analyze the selectivity of delta receptor subtypes to regulate different classes of G proteins, the expression of the alpha-subunits of Gi2, Gi3, Go1, Go2, Gq and G11 transducer proteins was reduced by administration of oligodeoxynucleotides (ODNs) complementary to sequences in their respective mRNAs.
Gene_expression (expression) of Go2
6) Confidence 0.02 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580632 Disease Relevance 0 Pain Relevance 0.41

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