INT75168

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 27
Disease Relevance 1.73
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHN1)
Anatomy Link Frequency
stem 4
CHN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 88.52 High High
Potency 52 74.64 Quite High
addiction 52 39.60 Quite Low
Opioid 26 5.00 Very Low Very Low Very Low
antagonist 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 182 95.92 Very High Very High Very High
Myocardial Infarction 1 93.32 High High
Coronary Artery Disease 5 91.64 High High
Infarction 1 89.92 High High
Cv General 3 Under Development 1 88.52 High High
Congenital Anomalies 3 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the coating of the viral RNA by about 2000 copies of NC relies largely on NC ability to bind to nearly any sequence of five to seven nucleotides length (44,47,50,54,55).
NC Binding (bind) of
1) Confidence 0.19 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0.18 Pain Relevance 0
The preferential binding of 3HC-NC(11–55) to SL14 was further assessed by the spectrum obtained in the presence of an equimolar mixture of (?)
NC Binding (binding) of
2) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
NC is thought to be critically involved in the reverse transcription, integration and encapsidation steps of the viral life cycle, mainly through interaction with nucleic acids (41).
NC Binding (interaction) of
3) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0.18 Pain Relevance 0
Interactions of 3HC-NC(11–55) with single binding site ODNs
NC Binding (Interactions) of
4) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
To determine whether this site is localized in the SL14 stem loop, we characterized the spectroscopic changes of 3HC-NC(11–55) resulting from its binding to the isolated SL14 sequence.
NC Binding (binding) of in stem
5) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0.06 Pain Relevance 0
NC binds both specifically (42–45) and non-specifically (46,47), to a large range of nucleic-acid sequences.
NC Binding (binds) of
6) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0.17 Pain Relevance 0
PBS were further supported by titration experiments, revealing that 3HC-NC(11–55) binds with 4-fold higher affinity to SL14 [1.0(±0.3)?
NC Binding (binds) of
7) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Though this assumption was adequate for obtaining good fits of the binding curves and comparing various NC mutants (65,73), it was recognized by the authors to be rather unrealistic, since NC binding is known to depend on the ODN sequence (44,50).
NC Binding (binding) of
8) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Specificity for NC was calculated to be 68.7% for group A and 91.3% for group B.
NC Binding (Specificity) of
9) Confidence 0.16 Published 1998 Journal Eur J Nucl Med Section Abstract Doc Link 9580853 Disease Relevance 0.73 Pain Relevance 0.09
Selectivity is supported by the interaction of the hydrophobic platform at the top of NC folded fingers with the GXG- containing loops of the SL2 and SL3 stem loop sequences of ?
NC Binding (top) of in stem
10) Confidence 0.15 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0.14 Pain Relevance 0
Figure 6.3D structure of NC complexes with SL2 (A); d(ACGCC) (B) and (?)
NC Binding (complexes) of
11) Confidence 0.15 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
This approach provided us new insights on the binding of NC to two target sequences of the (?)
NC Binding (binding) of
12) Confidence 0.14 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0.10 Pain Relevance 0
These sequences were selected since they preferentially bind one NC molecule per ODN and the 3D structures of their complexes with NC have been solved (52,53,76,77).
NC Binding (bind) of
13) Confidence 0.13 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
In this respect, knowing the spectroscopic response associated with the binding of 3HC-NC(11–55) to the (?)
NC Binding (associated) of
14) Confidence 0.13 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0.09 Pain Relevance 0
Figure 7.Normalized fluorescence spectra of 3HC-NC(11–55) complexes with SL3 (red), (?)
NC Binding (complexes) of
15) Confidence 0.13 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
These sequences were selected since they preferentially bind one NC molecule per ODN and the 3D structures of their complexes with NC have been solved (52,53,76,77).
NC Binding (complexes) of
16) Confidence 0.13 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
These sequences were selected since they preferentially bind one NC molecule per ODN and the 3D structures of their complexes with NC have been solved (52,53,76,77).
NC Binding (bind) of
17) Confidence 0.13 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Interactions of 3HC-NC(11–55) with single binding site ODNs
NC Binding (binding) of
18) Confidence 0.13 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
This indicates that 3HC-NC(11–55) first binds to sites giving a low N*:T* ratio while sites associated with higher N*:T* ratios are less affine, highlighting differences in the binding constants of the different sites.
NC Binding (binds) of
19) Confidence 0.13 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0
Finally, we characterized the interaction of 3HC-NC(11–55) with cTAR DNA, a stem-loop of 55 nucleotides involved in the NC-promoted first strand transfer, during reverse transcription (61,62,71).
NC Binding (interaction) of in stem
20) Confidence 0.13 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0

General Comments

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