INT75183

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 9.34
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
chest 2
heart 2
plasma 1
blood 1
tubes 1
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 64 99.80 Very High Very High Very High
ischemia 38 90.72 High High
anesthesia 7 80.92 Quite High
Inflammation 35 50.00 Quite Low
cytokine 7 50.00 Quite Low
Ultiva 4 50.00 Quite Low
Inflammatory marker 2 37.32 Quite Low
cva 21 11.12 Low Low
iatrogenic 1 9.60 Low Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Emergencies 18 100.00 Very High Very High Very High
Angina 52 99.80 Very High Very High Very High
Myocardial Infarction 129 99.26 Very High Very High Very High
Injury 102 98.72 Very High Very High Very High
Infarction 8 98.70 Very High Very High Very High
Syndrome 37 98.12 Very High Very High Very High
Disease 18 97.92 Very High Very High Very High
Acute Coronary Syndrome 86 96.44 Very High Very High Very High
Coronary Heart Disease 22 95.36 Very High Very High Very High
Cv General 3 Under Development 31 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Remifentanil preconditioning decreases the cTnI levels and reduces myocardial injury induced by OPCAB.


Negative_regulation (decreases) of cTnI
1) Confidence 0.53 Published 2009 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 19726290 Disease Relevance 0 Pain Relevance 0
Mean cTnI concentration was significantly lower at 6, 12, 24, and 48 h after surgery (ANOVA; P < 0.0001) in the RIPC patients (N = 27) than in controls (N = 26), resulting in a 44.5% reduction of cTnI (AUC at 72 h).
Negative_regulation (reduction) of cTnI
2) Confidence 0.49 Published 2010 Journal Basic Res. Cardiol. Section Abstract Doc Link 20495811 Disease Relevance 0.38 Pain Relevance 0.12
The cTnI levels of remifentanil preconditioning group were markedly decreased after the operation in comparison with those of the control group (P<0.05).
Negative_regulation (decreased) of cTnI
3) Confidence 0.46 Published 2009 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 19726290 Disease Relevance 0.06 Pain Relevance 0
Using commercially available immunoassays, clinical laboratories are able to determine cardiac TnT and TnI (cTnT and cTnI) quickly and reliably as classical cardiac markers.
Spec (determine) Negative_regulation (determine) of TnI
4) Confidence 0.42 Published 1999 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 10094373 Disease Relevance 0.21 Pain Relevance 0
However, some distinctive features in the subgroups scheduled for this study are present. (1) The mean values of cTnI in AMI patients who died, >60 years old and with anterolateral necrosis are constantly higher than in survivors, <60 years old and with inferoposterior necrosis, respectively. (2) The cTnI concentration is already returned in normal range at 7th day of illness course in survivors and in patients with inferoposterior AMI. (3) The 24-h peak level of cTnI is significantly higher in fibrinolysed than in patients who didn't undergo fibrinolysis. (4) A direct correlation between the cTnI value and the Killip class is present either in the whole group or in any subset of patients and the progressive decrease of the cTnI concentration along the AMI course doesn't occur in Killip>2 group. (5) cTnI is higher in unstable than in stable anginous patients and normal subjects but not in stable angina with respect to healthy controls.
Negative_regulation (decrease) of cTnI associated with necrosis, angina and myocardial infarction
5) Confidence 0.42 Published 2001 Journal Int. J. Cardiol. Section Abstract Doc Link 11182185 Disease Relevance 1.17 Pain Relevance 0.09
METHODS: Consecutive patients (n = 202) were included and divided into two groups according to the postoperative value of cTnI (< or >/= 13 ng/ml).
Negative_regulation (value) of cTnI
6) Confidence 0.39 Published 2003 Journal Anesthesiology Section Body Doc Link 12883398 Disease Relevance 0 Pain Relevance 0
Since the cTnI levels decrease to baseline within 5–10 days of the initial injury, it is important to obtain the blood samples as soon as myocardial injury is suspected [8].
Negative_regulation (decrease) of cTnI in blood associated with injury
7) Confidence 0.39 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.22 Pain Relevance 0
Gerhardt et al. have shown that the use of heparinized tubes for serum collection can lower reported cTnI levels, especially early in the course of the AICS disease process [39].
Negative_regulation (lower) of cTnI in tubes associated with syndrome and disease
8) Confidence 0.38 Published 2004 Journal BMC Emerg Med Section Body Doc Link PMC487900 Disease Relevance 0.90 Pain Relevance 0
Surprisingly, although each independent technique showed a marked rise of troponin-I from baseline to 6 hours post-operatively, the troponin release was not significant between the 2 groups at specified time intervals (p=0.124).
Negative_regulation (rise) of troponin-I
9) Confidence 0.34 Published 2006 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2323524 Disease Relevance 0.36 Pain Relevance 0
Although each independent technique showed a marked rise of troponin-I from baseline to 6 hours post-operatively, the difference in troponin release was not significant between the 2 groups at specified time intervals (p=0.124).
Negative_regulation (rise) of troponin-I
10) Confidence 0.34 Published 2006 Journal McGill Journal of Medicine : MJM Section Abstract Doc Link PMC2323524 Disease Relevance 0.41 Pain Relevance 0
OBJECTIVES: We sought to evaluate the diagnostic and prognostic value of cardiac troponin I (cTnI) in emergency department (ED) patients with chest pain.
Negative_regulation (value) of cTnI in chest associated with angina and emergencies
11) Confidence 0.34 Published 1998 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 9669242 Disease Relevance 0.35 Pain Relevance 0.17
OBJECTIVES: We sought to evaluate cardiac troponin I (cTnI) for predicting early clinical outcomes and the efficacy of enoxaparin among patients with non-ST segment elevation acute coronary syndrome (ACS) and negative creatine kinase, MB fraction (CK-MB) levels.
Negative_regulation (predicting) of cTnI associated with acute coronary syndrome
12) Confidence 0.22 Published 2000 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 11092649 Disease Relevance 0.17 Pain Relevance 0.07
We compared CK MB mass (upper reference limit, 5.0 ng/ml) and cardiac troponin I (cTnI; upper reference limit, 0.8 ng/ml) (Stratus II, Dade International) in serial serum specimens obtained over 36 h after chest pain from AMI patients; within 6 h after onset of chest pain.
Negative_regulation (compared) of cTnI in upper associated with angina and myocardial infarction
13) Confidence 0.19 Published 1998 Journal Clin. Chim. Acta Section Abstract Doc Link 9581857 Disease Relevance 0.88 Pain Relevance 0.36
CONCLUSION: The result suggested that PCI could lead to a detectable increase in serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could significantly decrease the serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could also decrease the serum levels of CRP, TNFalpha and cTnI in patients with PCI.


Negative_regulation (decrease) of cTnI in heart
14) Confidence 0.18 Published 2005 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 15932660 Disease Relevance 0.13 Pain Relevance 0
Serum levels of CRP, TNFalpha and cTnI were measured before and after two weeks treatment (in the early morning of the procedure) and at 24 hours after the procedure.
Negative_regulation (levels) of cTnI
15) Confidence 0.18 Published 2005 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 15932660 Disease Relevance 0.18 Pain Relevance 0
CONCLUSION: The result suggested that PCI could lead to a detectable increase in serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could significantly decrease the serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could also decrease the serum levels of CRP, TNFalpha and cTnI in patients with PCI.


Negative_regulation (levels) of cTnI in heart
16) Confidence 0.18 Published 2005 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 15932660 Disease Relevance 0.14 Pain Relevance 0
Of note was that dialysis increased troponin T values, but decreased troponin I values (cutoff 0.4 ng/ml) [76]; this effect was independent of the dialysis membrane used.
Negative_regulation (decreased) of troponin I
17) Confidence 0.17 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59629 Disease Relevance 0.77 Pain Relevance 0
Favorable results have been reported supporting the use of intracoronary shunt during LAD grafting regarding global as well as segmental LV function and reduced postoperative troponin I level (8, 10-12).
Negative_regulation (reduced) of troponin I
18) Confidence 0.17 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526513 Disease Relevance 0.40 Pain Relevance 0.04
Because H-FABP rapidly return to the normal range within 24 h after AMI, it can be also used to assess a recurrent infarction within 10 h after first AMI, possibly missed by CK-MB, cTnT and cTnI evaluation because plasma concentration of these markers returns more slowly to reference values.
Negative_regulation (evaluation) of cTnI in plasma associated with infarction and myocardial infarction
19) Confidence 0.16 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.70 Pain Relevance 0.05
The accelerated critical pathway for chest pain evaluation was analyzed for: (1) accuracy in triaging of patients within 90 minutes of presentation, (2) sensitivity, specificity, positive predictive value, and negative predictive value of cTnI, myoglobin, and CK-MB in diagnosing acute myocardial infarction (MI) within 90 minutes, and (3) impact on Coronary Care Unit (CCU) admissions.
Negative_regulation (value) of cTnI in chest associated with angina and myocardial infarction
20) Confidence 0.13 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11564382 Disease Relevance 0.90 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox