INT7521

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 1989
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.21
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NRL) DNA binding (NRL)
Anatomy Link Frequency
cortex 2
lateral reticular nucleus 1
nucleus 1
NRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 23 99.98 Very High Very High Very High
Catecholamine 4 87.44 High High
monoamine 3 86.48 High High
medulla 8 83.08 Quite High
Potency 3 82.32 Quite High
antagonist 1 75.76 Quite High
Locus ceruleus 3 39.44 Quite Low
Disease Link Frequency Relevance Heat
Hypotension 5 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TCP did not effect [3H]BFI binding in rat cortex, or [3H]idazoxan binding in human cortex and NRL.
NRL Binding (binding) of in cortex
1) Confidence 0.40 Published 1997 Journal Life Sci. Section Abstract Doc Link 9048963 Disease Relevance 0 Pain Relevance 0.17
Substances that had a structure similar to that of clonidine were able to compete with [3H]clonidine binding within the human NRL.
NRL Binding (binding) of associated with clonidine
2) Confidence 0.32 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2721559 Disease Relevance 0 Pain Relevance 0.83
Clonidine-like antihypertensive substances bind to nonadrenergic imidazoline specific sites within the nucleus reticularis lateralis (NRL), their medullary privileged site of action.
NRL Binding (bind) of in nucleus associated with clonidine
3) Confidence 0.31 Published 1992 Journal Am. J. Hypertens. Section Abstract Doc Link 1350728 Disease Relevance 0.21 Pain Relevance 0.19
Cirazoline was the most potent to inhibit [3H]clonidine binding although yohimbine was also able to displace binding in the human NRL but with lower apparent affinity.
NRL Binding (binding) of associated with clonidine
4) Confidence 0.31 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2721559 Disease Relevance 0 Pain Relevance 0.79
We characterized [3H]BFI binding in human brain cortex and lateral reticular nucleus (NRL).
NRL Binding (binding) of in cortex
5) Confidence 0.30 Published 1997 Journal Life Sci. Section Abstract Doc Link 9048963 Disease Relevance 0 Pain Relevance 0.12
We characterized [3H]BFI binding in human brain cortex and lateral reticular nucleus (NRL).
NRL Binding (binding) of in lateral reticular nucleus
6) Confidence 0.10 Published 1997 Journal Life Sci. Section Abstract Doc Link 9048963 Disease Relevance 0 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox