INT75224

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 23
Total Number 27
Disease Relevance 11.79
Pain Relevance 13.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
glial cell 8
brain 6
nerve 6
stem cell 4
spinal cord 3
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 471 100.00 Very High Very High Very High
Nerve growth factor 204 100.00 Very High Very High Very High
bDMF 128 100.00 Very High Very High Very High
Locus ceruleus 23 99.84 Very High Very High Very High
antidepressant 14 99.72 Very High Very High Very High
Morphine 20 99.70 Very High Very High Very High
fluoxetine 6 99.68 Very High Very High Very High
Endep 7 99.38 Very High Very High Very High
induced neuropathy 1 99.22 Very High Very High Very High
withdrawal 18 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 80 99.98 Very High Very High Very High
Herpes Simplex Virus 3 99.70 Very High Very High Very High
Brain Injury 13 99.68 Very High Very High Very High
Targeted Disruption 17 99.66 Very High Very High Very High
Urinary Dysfunction 64 99.56 Very High Very High Very High
Hydrocephalus 84 99.28 Very High Very High Very High
Neuropathic Pain 8 99.22 Very High Very High Very High
Glioblastoma 2 99.08 Very High Very High Very High
Spinal Cord Injury 269 98.04 Very High Very High Very High
Intracranial Hypertension 54 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3.
Positive_regulation (transfer) of Gene_expression (transfer) of neurotrophin-3 associated with herpes simplex virus, induced neuropathy and neuropathic pain
1) Confidence 0.69 Published 2002 Journal Ann. Neurol. Section Title Doc Link 11782980 Disease Relevance 0.70 Pain Relevance 0.22
We hypothesize that deficits in neurotrophic factor support, specifically linked to diabetes-induced lowered expression of insulin and neurotrophin-3, triggers alterations of sensory neurone phenotype that are critical for the development of abnormal Ca(2+) homeostasis and associated mitochondrial dysfunction.
Positive_regulation (induced) of Gene_expression (expression) of neurotrophin-3 associated with parkinson's disease and diabetes mellitus
2) Confidence 0.66 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18191198 Disease Relevance 1.17 Pain Relevance 0.05
Using in situ hybridization and immunohistochemical techniques, we have now found that nerve growth factor (NGF) and neurotrophin-3 (NT3) synthesis is upregulated in satellite cells surrounding neurons in lesioned DRG as early as 48 h after nerve injury.
Positive_regulation (upregulated) of Gene_expression (synthesis) of NT3 in nerve associated with nervous system injury and nerve growth factor
3) Confidence 0.48 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10215925 Disease Relevance 0.60 Pain Relevance 0.39
Using in situ hybridization and immunohistochemical techniques, we have now found that nerve growth factor (NGF) and neurotrophin-3 (NT3) synthesis is upregulated in satellite cells surrounding neurons in lesioned DRG as early as 48 h after nerve injury.
Positive_regulation (upregulated) of Gene_expression (synthesis) of neurotrophin-3 in nerve associated with nervous system injury and nerve growth factor
4) Confidence 0.48 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10215925 Disease Relevance 0.61 Pain Relevance 0.39
Results showed that chronic administration of morphine significantly increased BDNF and NT-3 gene expression in PGi.
Positive_regulation (increased) of Gene_expression (expression) of NT-3 gene associated with bdmf and morphine
5) Confidence 0.48 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.15 Pain Relevance 1.66
Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.
Positive_regulation (induced) of Gene_expression (source) of NT-3 in oligodendrocytes associated with nerve growth factor
6) Confidence 0.46 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.63 Pain Relevance 0.79
We propose that increased NGF and NT-3 production represent adaptive responses of the brain to prolonged elevated ICP.


Positive_regulation (increased) of Gene_expression (production) of NT-3 in brain associated with nerve growth factor and cva
7) Confidence 0.46 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.80 Pain Relevance 0.65
For establishment of a clonal "hMSC-NT3" line, single clones were grown and screened for NT3 expression by ELISA and RT-PCR (see further).
Positive_regulation (screened) of Gene_expression (expression) of NT3
8) Confidence 0.46 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0
The NT-3 gene was transferred into NSCs via the pLEGFP-C1, an expression plasmid vectors.
Positive_regulation (transferred) of Gene_expression (transferred) of NT-3 gene in NSCs
9) Confidence 0.44 Published 2008 Journal Chin. J. Traumatol. Section Body Doc Link 18822188 Disease Relevance 0 Pain Relevance 0
HFES of sympathetic neurons induced a frequency dependent NGF and NT-3 gene and protein up-regulation (relative NGF protein expression: 0Hz=1+/-0.0 vs. 5Hz=1.13+/-0.19 vs. 50Hz=1.77+/-0.08, all n=5, 0Hz/5Hz vs. 50Hz p<0.05), with a subsequent increase of growth associated protein 43 (GAP-43) expression and morphological SNS.
Positive_regulation (induced) of Gene_expression (expression) of NT-3 gene in neurons associated with nerve growth factor
10) Confidence 0.43 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.32 Pain Relevance 0.47
PGi nucleus was assayed for the expression of BDNF and NT-3 using semi-quantitative RT-PCR normalized to beta-actin gene expression.
Positive_regulation (assayed) of Gene_expression (expression) of NT-3 in nucleus associated with bdmf
11) Confidence 0.42 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.21 Pain Relevance 1.93
However, due to this low level of NT3 mRNA produced by transgenic hMSC-NT3 cells, NT3 transgene expression following transplantation of hMSC-NT3 cells in rat spinal cord could not be detected (Figure 3).
Positive_regulation (following) of Gene_expression (expression) of NT3 in spinal cord associated with targeted disruption and spinal cord
12) Confidence 0.31 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.25 Pain Relevance 0.11
But locomotor improvement was not obvious and neurogenic bladder and mRNA and protein levels of BDNF and NT-3 were unchanged after stem cell transplantation.


Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (levels) of NT-3 in stem cell associated with urinary dysfunction and bdmf
13) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2955046 Disease Relevance 1.04 Pain Relevance 0.45
Mahmood et al.[36] and Kim et al. [37] transplanted rat or human MSCs into an in vivo model of traumatic brain injury and found that expression of BDNF, NT-3 and/or nerve growth factor were increased.
Positive_regulation (increased) of Gene_expression (expression) of NT-3 in nerve associated with nerve growth factor, bdmf and brain injury
14) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2955046 Disease Relevance 0.83 Pain Relevance 0.63
In our study, endogenous BDNF and NT-3 levels in the spinal cord and bladder were unchanged after hMSCs transplantation and these results may explain unrecovered neurogenic bladder.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (levels) of NT-3 in bladder associated with urinary dysfunction, bdmf and spinal cord
15) Confidence 0.22 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2955046 Disease Relevance 1.12 Pain Relevance 0.43
Boosting of regenerative capability of OECs by overexpression of brain-derived neurotrophic factor (BDNF) [50] or glial cell line-derived neurotrophic factor (GDNF) [51] was also tried successfully in animal models.
Positive_regulation (overexpression) of Gene_expression (overexpression) of neurotrophic factor in glial cell
16) Confidence 0.16 Published 2007 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1876804 Disease Relevance 0.23 Pain Relevance 0.11
New experimental evidence suggests that the mechanism of action of antidepressants includes the induction of neurotrophic factor synthesis in selected brain areas.
Positive_regulation (induction) of Gene_expression (synthesis) of neurotrophic factor in brain associated with antidepressant
17) Confidence 0.16 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.41
Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.
Positive_regulation (induced) of in Astrocytes Gene_expression (source) of NT-3 in oligodendrocytes associated with nerve growth factor
18) Confidence 0.16 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.63 Pain Relevance 0.79
As well, expression of mRNAs for the neurotrophins NGF, BDNF, and NT-3 was examined. p75, trkA, and GAP-43 mRNAs were upregulated in DRGs from the NGF-treated, but not the control animals.
Positive_regulation (upregulated) of Spec (examined) Gene_expression (expression) of NT-3 in DRGs
19) Confidence 0.15 Published 1998 Journal Exp. Neurol. Section Abstract Doc Link 9582251 Disease Relevance 0.15 Pain Relevance 0
on the expression of several neurotrophic factors such as NGF, IGF-1, and NT-3
Positive_regulation (as) of Gene_expression (expression) of NT-3 associated with nerve growth factor
20) Confidence 0.15 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.55 Pain Relevance 0.28

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