INT75225

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1998
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.95
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
brain 2
spinal 1
nerve 1
nucleus 1
DRGs 1
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 8 100.00 Very High Very High Very High
peripheral neuropathy 10 99.86 Very High Very High Very High
Paracetamol 7 97.80 Very High Very High Very High
Spinal nerve ligature 2 97.68 Very High Very High Very High
Somatostatin 1 95.28 Very High Very High Very High
Dorsal column 2 95.08 Very High Very High Very High
Inflammation 14 94.72 High High
Pain 3 94.16 High High
allodynia 2 92.84 High High
Antinociceptive 2 83.44 Quite High
Disease Link Frequency Relevance Heat
Peripheral Neuropathy 10 99.86 Very High Very High Very High
INFLAMMATION 10 94.72 High High
Pain 1 94.16 High High
Neuropathic Pain 4 92.84 High High
Nociception 7 88.60 High High
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that mRNA expression levels of alpha-calcitonin gene-related peptides, tropomyosin-related kinase-A (trkA), p75 neurotrophin receptor (p75(NTR)), and brain-derived neurotrophic factor (BDNF) elevated significantly after CFA treatment.
Transcription (levels) of p75 in brain
1) Confidence 0.60 Published 2007 Journal J Pain Section Abstract Doc Link 17010673 Disease Relevance 0.39 Pain Relevance 0.19
Our results showed that mRNA expression levels of alpha-calcitonin gene-related peptides, tropomyosin-related kinase-A (trkA), p75 neurotrophin receptor (p75(NTR)), and brain-derived neurotrophic factor (BDNF) elevated significantly after CFA treatment.
Transcription (levels) of p75 in brain
2) Confidence 0.60 Published 2007 Journal J Pain Section Abstract Doc Link 17010673 Disease Relevance 0.39 Pain Relevance 0.19
Differential change in mRNA expression of p75 and Trk neurotrophin receptors in nucleus gracilis after spinal nerve ligation in the rat.
Transcription (expression) of p75 in nucleus associated with spinal nerve ligature
3) Confidence 0.57 Published 2004 Journal Exp. Neurol. Section Title Doc Link 15144880 Disease Relevance 0.45 Pain Relevance 0.57
To assess NTs in the NuGr in PN, mRNA expression of BDNF, nerve growth factor (NGF), and NT receptors TrkA, TrkB, and p75 was determined 1 week after ligation of L5 and L6 spinal nerves (SNL).
Spec (determined) Transcription (expression) of p75 in nerve associated with nerve growth factor and peripheral neuropathy
4) Confidence 0.55 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15144880 Disease Relevance 0.47 Pain Relevance 0.57
The dorsal root ganglia (DRGs) were sampled at various times throughout the experiment and processed for in situ hybridization to examine mRNA expression of the NGF receptors (p75 and trkA) and GAP-43.
Spec (examine) Transcription (expression) of p75 in DRGs
5) Confidence 0.39 Published 1998 Journal Exp. Neurol. Section Abstract Doc Link 9582251 Disease Relevance 0.16 Pain Relevance 0
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Transcription (transcript) of neurotrophin receptor in spinal associated with paracetamol and somatostatin
6) Confidence 0.12 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.91

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox