INT75228

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 0.95
Pain Relevance 6.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 2
oocytes 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 99 100.00 Very High Very High Very High
opioid receptor 41 100.00 Very High Very High Very High
Immobilon 22 99.98 Very High Very High Very High
Enkephalin 5 99.96 Very High Very High Very High
chemokine 8 99.68 Very High Very High Very High
tolerance 9 99.48 Very High Very High Very High
Analgesic 1 99.28 Very High Very High Very High
Morphine 29 99.12 Very High Very High Very High
Central nervous system 1 98.08 Very High Very High Very High
opiate 7 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 8 100.00 Very High Very High Very High
Lordosis 3 89.08 High High
Targeted Disruption 3 86.40 High High
Bordatella Infection 4 82.16 Quite High
Pain 1 78.24 Quite High
INFLAMMATION 1 76.08 Quite High
Hyperalgesia 1 70.16 Quite High
Contagious Ecthyma 14 47.40 Quite Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results of radioligand binding and transfected receptor studies indicate that mu-receptor down-regulation and phosphorylation may be critical to the expression of morphine tolerance.
Spec (may) Positive_regulation (critical) of Negative_regulation (regulation) of mu-receptor associated with tolerance and morphine
1) Confidence 0.49 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9582426 Disease Relevance 0 Pain Relevance 0.81
Together these results indicate that estrogen induces a MOR mediated inhibition of sexual receptivity.
Positive_regulation (induces) of Negative_regulation (inhibition) of MOR associated with opioid receptor
2) Confidence 0.42 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.42 Pain Relevance 0.77
Both morphine and etorphine induce tolerance; however, only etorphine produces mu-opioid receptor (muOR) down-regulation.
Positive_regulation (produces) of Negative_regulation (down-regulation) of muOR associated with tolerance, opioid receptor, immobilon and morphine
3) Confidence 0.42 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435815 Disease Relevance 0 Pain Relevance 1.04
Both morphine and etorphine induce tolerance; however, only etorphine produces mu-opioid receptor (muOR) down-regulation.
Positive_regulation (produces) of Negative_regulation (down-regulation) of mu-opioid receptor associated with tolerance, opioid receptor, immobilon and morphine
4) Confidence 0.42 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435815 Disease Relevance 0 Pain Relevance 1.04
The MOR uORF uses a mechanism independent of peptide sequence, and translational repression of MOR uORF is not dependent on the intercistronic region.
Neg (not) Positive_regulation (dependent) of Negative_regulation (repression) of MOR uORF associated with repression and mu opioid receptor
5) Confidence 0.42 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.10 Pain Relevance 0.32
Activation of MOR by the stable enkephalin analogue, [d-Ala(2),MePhe(4),Glyol(5)]enkephalin, led to homologous MOR desensitization in oocytes coexpressing both G-protein-coupled receptor kinase 3 (GRK3) and beta-arrestin 2 (arr3).
Positive_regulation (led) of Negative_regulation (desensitization) of MOR in oocytes associated with enkephalin and opioid receptor
6) Confidence 0.12 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11060299 Disease Relevance 0 Pain Relevance 0.64
Using a T394A mutant receptor, we determined that Thr(394) was also responsible for mu opioid receptor down-regulation.
Positive_regulation (responsible) of Negative_regulation (down-regulation) of mu opioid receptor associated with mu opioid receptor
7) Confidence 0.07 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10488100 Disease Relevance 0.21 Pain Relevance 0.52
Conversely, activation of chemokine receptors also induces heterologous desensitization of mu-opioid receptors (MOR), a class of key analgesic receptors on neurons.
Positive_regulation (induces) of Negative_regulation (desensitization) of MOR in neurons associated with chemokine, analgesic and mu opioid receptor
8) Confidence 0.05 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204635 Disease Relevance 0.22 Pain Relevance 0.91
Substitution with the large, lipophilic cyclooctylmethyl moiety increased ORL1 receptor affinity and decreased mu receptor affinity and efficacy in the fentanyl series of ligands but had a different effect in the oripavine class of opiate ligands.
Positive_regulation (increased) of Negative_regulation (decreased) of mu receptor associated with opiate
9) Confidence 0.00 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11779034 Disease Relevance 0 Pain Relevance 0.85

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