INT7523

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 42
Total Number 47
Disease Relevance 11.63
Pain Relevance 14.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
plasma 4
lower urinary tract 2
veins 2
myocardium 1
forearm 1
ADRA1D (Homo sapiens)
ADRA1D - S270H (1)
Pain Link Frequency Relevance Heat
antagonist 60 100.00 Very High Very High Very High
agonist 39 100.00 Very High Very High Very High
noradrenaline 15 100.00 Very High Very High Very High
isoflurane 10 100.00 Very High Very High Very High
Cannabinoid 10 100.00 Very High Very High Very High
Serotonin 3 99.96 Very High Very High Very High
spinal inflammation 4 99.88 Very High Very High Very High
Inflammation 5 99.80 Very High Very High Very High
Clonidine 40 99.52 Very High Very High Very High
ergotamine 3 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 9 100.00 Very High Very High Very High
Disease 5 100.00 Very High Very High Very High
Hemorrhage 2 100.00 Very High Very High Very High
Low Back Pain 4 99.88 Very High Very High Very High
Congenital Anomalies 1 99.36 Very High Very High Very High
Angina 1 98.56 Very High Very High Very High
Pain 29 98.48 Very High Very High Very High
Stress Incontinence 17 98.36 Very High Very High Very High
Chronic Pelvic Pain Syndrome 4 98.32 Very High Very High Very High
Pressure Volume 2 Under Development 9 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test the hypothesis that vascular pain depends on sympathetic drive under physiological conditions we studied the effects of both alpha-adrenoceptor stimulation by noradrenaline and alpha-adrenoceptor blockade by phentolamine on the intensity of physicochemically evoked pain from veins in humans.
Regulation (effects) of alpha-adrenoceptor in veins associated with pain and noradrenaline
1) Confidence 0.45 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9203566 Disease Relevance 0.46 Pain Relevance 0.59
To test the hypothesis that vascular pain depends on sympathetic drive under physiological conditions we studied the effects of both alpha-adrenoceptor stimulation by noradrenaline and alpha-adrenoceptor blockade by phentolamine on the intensity of physicochemically evoked pain from veins in humans.
Regulation (effects) of alpha-adrenoceptor in veins associated with pain and noradrenaline
2) Confidence 0.45 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9203566 Disease Relevance 0.40 Pain Relevance 0.44
The effect of alpha-adrenergic and serotonergic receptor agonists and antagonists on forearm venous capacitance and vascular resistance was studied in normal subjects.
Regulation (effect) of alpha-adrenergic in forearm associated with antagonist and agonist
3) Confidence 0.45 Published 1992 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1376824 Disease Relevance 0 Pain Relevance 0.34
In radioligand-binding experiments, eugenosedin-B had significant binding affinities on alpha1, alpha2, beta1, 5-HT1B, and 5-HT2A receptors.
Regulation (affinities) of alpha1
4) Confidence 0.44 Published 2008 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 18287883 Disease Relevance 0.35 Pain Relevance 0.28
The relatively high affinity of the alpha-1 antagonist prazosin for (3H)-rauwolscine binding sites in rat cerebral cortex was not observed in the human tissue which had pharmacological properties similar to those described previously in human platelet.
Regulation (affinity) of alpha-1 in platelet associated with antagonist and cerebral cortex
5) Confidence 0.44 Published 1983 Journal Life Sci. Section Abstract Doc Link 6136881 Disease Relevance 0 Pain Relevance 0.48
Postoperative changes in various haemostatic parameters (capillary bleeding time, platelet count, fibrinogen, fibrinmonomers, prothrombin, antithrombin III, factor VIII procoagulant, factor VIII antigen, euglobulin clot lysis time, streptokinase lysis time, fibrinogen related antigens, alpha 1-antitrypsin and alpha 2-macroglobulin) plasma glucose and cortisol were studied in 12 female patients undergoing elective abdominal hysterectomy during either general anaesthesia or epidural analgesia (T4-S5).
Regulation (changes) of alpha 1 in plasma associated with epidural, hemorrhage and analgesia
6) Confidence 0.44 Published 1981 Journal Br J Surg Section Abstract Doc Link 7225737 Disease Relevance 0.16 Pain Relevance 0.49
The influence of drug interaction and protein variants on the binding disposition of ropivacaine to alpha1-acid glycoprotein (AGP) was examined.
Regulation (influence) of alpha1
7) Confidence 0.44 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17227622 Disease Relevance 0 Pain Relevance 0.08
The exercise did not appear to significantly affect serum levels of alpha-1-antitrypsin and alpha-1-acid glycoprotein.
Regulation (affect) of alpha-1
8) Confidence 0.44 Published 1995 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 7588680 Disease Relevance 0.54 Pain Relevance 0.14
As the catecholamines have long been implicated in attentional processes, the present investigation compared the effects of the mixed alpha 1/alpha 2 adrenoceptor agonist clonidine (CLO), the benzodiazepine diazepam (DZP), the D1/D2 antagonist haloperidol (HAL) and a low-tryptophan drink (Lo-TRP) on performance of tests of selective attention with distractors in four groups of young, healthy volunteers.
Regulation (effects) of alpha 1 associated with antagonist, catecholamine, agonist and clonidine
9) Confidence 0.44 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8545528 Disease Relevance 0 Pain Relevance 0.48
The binding of DA-5018 was dependent on alpha-1-acid glycoprotein and HSA concentrations.
Regulation (dependent) of alpha-1
10) Confidence 0.44 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8824935 Disease Relevance 0 Pain Relevance 0.07
Regulation of the expression of the proenkephalin gene in cultured meningeal fibroblasts: opposite effects of alpha 1- and beta 2-adrenoceptors.
Regulation (effects) of alpha 1 in fibroblasts associated with enkephalin
11) Confidence 0.44 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8897441 Disease Relevance 0 Pain Relevance 0.31
Post-synaptic inhibitory mechanisms of anaesthesia; glycine receptors.

(1) The effects on human homomeric alpha1 glycine receptors of 11 general anaesthetics; four barbiturates, two other intravenous anaesthetics, three volatile anaesthetics and two simple gaseous anaesthetics are described. (2) Pentobarbital and thiopental potentiate the current response to bath applied glycine (50 microM) by 200 and 300%, respectively, at clinically relevant concentrations. (3) Neither methohexital nor phenobarbital had any effect on the current response to bath applied glycine (50 microM). (4) Using maximal doses of applied glycine (1 mM) all the barbiturates acted as non-competitive antagonists. (5) Propofol and etomidate potentiate the current response to bath applied glycine (50 microM) by 200 and 10%, respectively, at clinically relevant concentrations. (6) Etomidate acts as a non-competitive antagonist for doses of glycine above the EC50 (197 microM).

Regulation (effects) of alpha1 associated with anesthesia and antagonist
12) Confidence 0.44 Published 1998 Journal Toxicol. Lett. Section Title Doc Link 10049183 Disease Relevance 0 Pain Relevance 0.20
Modulation of alpha1-receptors may function in the management of lower urinary tract dysfunction in MSA.
Regulation (Modulation) of alpha1 in lower urinary tract associated with multiple system atrophy
13) Confidence 0.44 Published 2000 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10699651 Disease Relevance 0.85 Pain Relevance 0.07
A number of derivatives structurally related to cirazoline (1) were synthesized and studied with the purpose of modulating alpha2-adrenoreceptors selectivity versus both alpha1-adrenoreceptors and I2 imidazoline binding sites.
Regulation (modulating) of alpha1
14) Confidence 0.44 Published 2002 Journal J. Med. Chem. Section Abstract Doc Link 11754577 Disease Relevance 0 Pain Relevance 0.15
alpha1,4-N-Acetylglucosaminyltransferase (alpha4GnT) is a glycosyltransferase responsible for the biosynthesis of alpha1,4-GlcNAc-capped O-glycans, and is frequently expressed in pancreatic cancer cells but not peripheral blood cells.
Regulation (responsible) of alpha1 in blood cells associated with pancreatic cancer
15) Confidence 0.44 Published 2006 Journal Cancer Sci. Section Abstract Doc Link 16441422 Disease Relevance 0.45 Pain Relevance 0.07
There was a positive correlation between plasma alpha 1-acid glycoprotein concentrations and the binding ratio (bound/free concentrations) of lidocaine (p less than 0.001; r = 0.623) and propranolol (p less than 0.001); r = 0.652), indicating that it is likely that the elevation of the free fraction of these drugs in the fetus is due in part to lower levels of alpha 1-acid glycoprotein.
Regulation (due) of alpha 1 in plasma associated with lidocaine
16) Confidence 0.44 Published 1981 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7471620 Disease Relevance 0 Pain Relevance 0.30
In PC and PA strips, the alpha 1-adrenoceptor antagonist prazosin was more effective than the alpha 2-adrenoceptor antagonist rauwolscine to inhibit NA-induced contractions.
Regulation (effective) of alpha 1 associated with antagonist and noradrenaline
17) Confidence 0.44 Published 1985 Journal J. Urol. Section Abstract Doc Link 2414474 Disease Relevance 0.23 Pain Relevance 0.57
[The urodynamic effects of an alpha 1-adrenoceptor agonist on the bladder and urethra of female dogs].
Regulation (effects) of alpha 1 in urethra associated with stress incontinence and agonist
18) Confidence 0.44 Published 1991 Journal Nippon Hinyokika Gakkai Zasshi Section Title Doc Link 1717731 Disease Relevance 0.42 Pain Relevance 0.21
Clonidine expressed differential effects on alpha 1-adrenergic receptors of the neuronal and astrocytic glial cultures.
Regulation (effects) of alpha 1 in neuronal associated with clonidine
19) Confidence 0.44 Published 1990 Journal Brain Res. Section Abstract Doc Link 1979238 Disease Relevance 0 Pain Relevance 0.55
Sulphasalazine therapy in ankylosing spondylitis: its effect on disease activity, immunoglobulin A and the complex immunoglobulin A-alpha-1-antitrypsin.
Regulation (effect) of alpha-1 associated with spinal inflammation and disease
20) Confidence 0.44 Published 1989 Journal Br. J. Rheumatol. Section Title Doc Link 2571386 Disease Relevance 0.38 Pain Relevance 0.35

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