INT75250

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.47
Pain Relevance 5.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
spinal 2
spinal cord 2
head 2
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 25 100.00 Very High Very High Very High
Spinal cord 3 100.00 Very High Very High Very High
Hyperalgesia 1 100.00 Very High Very High Very High
antagonist 1 99.84 Very High Very High Very High
Clonidine 7 99.66 Very High Very High Very High
local anesthetic 11 99.56 Very High Very High Very High
Glutamate 1 97.20 Very High Very High Very High
Dorsal horn neuron 1 95.32 Very High Very High Very High
anesthesia 6 94.64 High High
intrathecal 1 94.20 High High
Disease Link Frequency Relevance Heat
Injury 2 100.00 Very High Very High Very High
Hyperalgesia 1 100.00 Very High Very High Very High
Nervous System Injury 2 99.92 Very High Very High Very High
INFLAMMATION 5 99.86 Very High Very High Very High
Cancer 2 96.16 Very High Very High Very High
Apoptosis 4 95.08 Very High Very High Very High
Metastasis 2 94.16 High High
Stress 2 89.36 High High
Sleep Disorders 1 88.64 High High
Pressure And Volume Under Development 1 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases.
Negative_regulation (block) of Positive_regulation (activation) of MAP associated with inflammation and cinod
1) Confidence 0.57 Published 2008 Journal Cell. Signal. Section Title Doc Link 18374541 Disease Relevance 0.48 Pain Relevance 0.54
We conclude that clonidine is effective in reducing the MAP increase with pin head-holder application in patients undergoing craniotomy.
Negative_regulation (reducing) of Positive_regulation (increase) of MAP in head associated with clonidine
2) Confidence 0.42 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9585285 Disease Relevance 0.18 Pain Relevance 0.98
The activation of MAP kinases by H(2)O(2) and NSAIDs was suppressed by quinone reductase inhibitors, suggesting that "redox cycling" was involved in the activation mechanisms of MAP kinases by H(2)O(2) and NSAIDs.
Negative_regulation (suppressed) of Positive_regulation (activation) of MAP associated with cinod
3) Confidence 0.41 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.46 Pain Relevance 0.96
Activation of p38 and p42/44 MAP kinases in spinal cord ipsilateral to constriction injury was reduced by antagonists of NMDA, VPAC2 and NK2 (but not related) receptors, the glial inhibitor propentofylline and inhibitors of TNF-alpha.
Negative_regulation (reduced) of Positive_regulation (Activation) of MAP in spinal cord associated with antagonist, injury and spinal cord
4) Confidence 0.41 Published 2005 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16202621 Disease Relevance 0.27 Pain Relevance 0.41
Activation of spinal cord mitogen-activated protein (MAP) kinases, which are essential for the hyperalgesia following injury or incision and occur in both neurons and glia, is inhibited by spinal local anesthetics.
Negative_regulation (inhibited) of Positive_regulation (Activation) of MAP in spinal associated with hyperalgesia, injury, local anesthetic and spinal cord
5) Confidence 0.41 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087121 Disease Relevance 0.59 Pain Relevance 1.81
Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases.
Negative_regulation (suppress) of Positive_regulation (activation) of MAP associated with inflammation and cinod
6) Confidence 0.41 Published 2008 Journal Cell. Signal. Section Title Doc Link 18374541 Disease Relevance 0.48 Pain Relevance 0.54

General Comments

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