INT75279

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Context Info
Confidence 0.33
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cyb5) mitochondrion (Cyb5) endoplasmic reticulum (Cyb5)
enzyme binding (Cyb5)
Cyb5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 52.80 Quite High
local anesthetic 1 46.64 Quite Low
Versed 64 30.56 Quite Low
Bioavailability 14 8.72 Low Low
Immobilon 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Methemoglobinemia 4 75.00 Quite High
Cyanosis 2 74.80 Quite High
Disease 1 51.28 Quite High
Coma 1 25.00 Low Low
Hypoxia 1 25.00 Low Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It does seem clear however, that
cytochrome b5 binding can cause conformational changes to
the substrate access channel and binding pocket in the P450 enzyme
(1,
17). 
cytochrome b5 Binding (binding) of
1) Confidence 0.33 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2581580 Disease Relevance 0 Pain Relevance 0
This suggests that cytochrome b5 binding does
not cause a conformational change in the structure of the P450s responsible
for this metabolism. 
cytochrome b5 Binding (binding) of
2) Confidence 0.33 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2581580 Disease Relevance 0 Pain Relevance 0.05
This action is considered to be autooxidation and it is simultaneously reduced by creation of "complex formation" of MetHb and cytochrome b5.
cytochrome b5 Binding (formation) of
3) Confidence 0.01 Published 1998 Journal Cas. Lek. Cesk. Section Abstract Doc Link 9588101 Disease Relevance 0.26 Pain Relevance 0

General Comments

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